Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 85 for “"H. pylori"”.
-
NATURAL SOURCES OF ELLAGITANNINS TO COUNTERACT H. PYLORI INFECTION
Helicobacter pylori è un batterio Gram negativo che colonizza la mucosa gastrica di circa il 50 % della popolazione mondiale. È ritenuto agente scatenante di varie patologie gastriche, dalla gastrite cronica all’ulcera peptica, ed è strettamente correlato all’insorgenza di cancro gastrico. La …
-
Molecular characterization of a sphingomyelin binding site in the vacuolating cytotoxin of H. pylori
… is the primary receptor for the Helicobacter pylori vacuolating cytotoxin (VacA). While the cellular receptor has been identified, the molecular basis of SM recognition remains unknown. Molecular modeling of unrelated SM-binding proteins suggests that specific binding occurs through tryptophan …
-
Increased BCA-1 Expression and Attenuated Apoptosis in Epithelial Cells in Helicobacter pylori-associated Low Grade Gastric MALT Lymphogenesis
BACKGROUND: Helicobacter pylori(H. pylori) infection is one of the major causes of the pathogenesis of low grade gastric MALT lymphoma(MALToma), but the reason why only a few patients with H. pylori infection developed MALToma was not clearly explained yet. Here, we provide novel finding that …
-
Nachweis und genetische Analyse der cag Pathogenitätsinsel von Helicobacter pylori mit neuen, molekularbiologischen Methoden
… cag-PAI ist ein wichtiger Virulenzfaktor von H. pylori und mit schwereren <br>Krankheitsverläufen der H. pylori-Infektion wie Magenulkus- und Malignombildung <br>assoziiert. Im Rahmen dieser Arbeit wurden zwei diagnostische Methoden zur Analyse der cag-PAI von H. pylori etabliert. Dabei konnte …
-
Funktionelle Charakterisierung der Ionentransportproteine CorA, NccB und CzcA von Helicobacter pylori
Das gram-negative Bakterium Helicobacter pylori besiedelt die Magenschleimhaut des Menschen und verursacht die chronisch aktive Gastritis vom Typ B und die peptische Ulkuskrankheit. Für die Adaptation an das Habitat Magen ist die bakterielle Metall-ionenhomöostase von grundlegender Bedeutung und …
-
Protective Mechanism of Epigallocatechin-3-gallate against Helicobacter pylori- induced Gastric Epithelial Cytotoxicity via Blockage of TLR-4 Signaling
Helicobacter pylori infection leads to gastric mucosal damage by several mechanisms including the direct effect of virulence factors produced by H. pylori, propagation of inflammation, oxidative stress, DNA damage, and induction of apoptosis. (-)-Epigallocatechin-3-gallate (EGCG), one of green tea …
-
Expression of interleukin-16 in gastric mucosa: a possible role in the persistance of helicobacter pylori infection
Helicobacter pylori (H. pylori) infects the human gastric mucosa of >50% of humankind and causes chronic gastritis, peptic ulcers, and gastric adenocarcinoma. H. pylori infected gastric epithelial cells (GECs) produce an array of chemokines that recruit other cells. IL-16 is potentially a key …
-
A genetic screen to identify novel Helicobacter pylori virulence factors using Saccharomyces cerevisiae as a model eukaryotic cell
<p>"Helicobacter pylori is a spiral, gram-negative bacterium that colonizes the stomachs of approximately 50% of the World's population overall and is a major etiological agent of human gastric adenocarcinoma. Of infected individuals, only 10-15% develop severe gastric disease due to environmental …
-
Helicobacter pylori and its Association with Gastric and Oesophageal Carcinomas
Helicobacter pylori is one of the most common infections in man. The infection is often acquired during childhood and usually results in a chronic life-long inflammation in the gastric mucosa. The aim of our studies was to investigate the association between H. pylori seropositivity and the …
-
Helicobacter pylori Type 4 Secretion System Modulates Host T Cell Responses
Infection with Helicobacter pylori (H. pylori) bacteria is associated with gastritis, peptic ulcer, and gastric cancer. During H. pylori infection CD4+ T cells in the gastric lamina propria are hyporesponsive and polarized to Th1/Th17 cell responses controlled by Treg cells. Gastric epithelial …
-
The role of helicobacter pylori infection in adults presenting with spontaneous gastroduodenal perforation at the University Teaching hospitals, Lusaka Zambia.
… It is well established that Helicobacter pylori (H. pylori) is the main cause of peptic ulcer disease. The prevalence of H. pylori infection in gastroduodenal perforation varies with geography, age, race, ethnicity and socioeconomic status. The correlation between H. pylori infection and …
-
The role of helicobacter pylori infection in adults presenting with spontaneous gastroduodenal perforation at the University Teaching hospitals, Lusaka Zambia.
… It is well established that Helicobacter pylori (H. pylori) is the main cause of peptic ulcer disease. The prevalence of H. pylori infection in gastroduodenal perforation varies with geography, age, race, ethnicity and socioeconomic status. The correlation between H. pylori infection and …
-
HcpE, a potential immuno-modulatory protein from Helicobacter pylori that is dependent on the Disulfide bond protein DsbHP
H. pylori is a human gastric pathogen that colonizes ~ 50% of the world’s population. It can cause gastritis, gastric or duodenal ulcers and also gastric cancer. H. pylori produces Helicobacter cysteine rich protein HcpE, a secreted protein which may play a role in virulence. In this study we show …
-
Charakterisierung der Helicobacter pylori-assoziierten Magenadenokarzinogenese am Tiermodell des Mongolischen Gerbils: Rolle der cag-Pathogenitätsinsel bei der Induktion präkanzeröser Prozesse.
Helicobacter pylori ist ein spiralförmiges, gramnegatives, mikroaerophiles und motiles Bakterium. Der humanpathogene Keim adhäriert an die Magenepithelzellen, wodurch eine Signaltransduktionskaskade gestartet wird, die in der Induktion von Zytokinen, der Infiltration von immunreaktiven Zellen und …
-
Pathogenesis of the carcinogenic bacterium, Helicobacter pylori
… for gastric cancer, including Helicobacter pylori infection, low fruit and vegetable intake, N-nitrosoamine exposure, high salt diet, and smoking. Among these risk factors, H. pylori infection is the major cause of gastric cancer. Therefore, H. pylori has been classified as a type 1 …
-
The role of DNA supercoiling in the coordinated regulation of gene expression in Helicobacter pylori
… silencing and gene activation. In Helicobacter pylori, a bacterium with few dedicated transcriptional regulators, the structure of some promoters indicates a dependency on DNA topology. For example, the promoter of the major flagellar subunit gene flaA (ó28-dependent) has a shorter spacing of 13 …
-
Untersuchung der Helicobacter pylori-vermittelten Aktivierung des Immunmodulators NF-kB in Magenepithelzellen
H. pylori aktiviert in Magenepithelzellen NF-kB, was zu einer gesteigerten IL-8-Sekretion und zum Einwandern neutrophiler Granulozyten führt. Die wichtigste Voraussetzung für die NF-kB Aktivierung ist das Vorhandensein der Pathogenitätsinsel cagPAI, welche für ein Typ-IV-Sekretionssystem codiert. …
-
Transkriptionelle Analyse der Urease-Expression in Helicobacter pylori : Identifikation neuer bakterieller Faktoren, die für die Urease-Aktivität essentiell sind
… des säureresistenten Magenbakteriums H. pylori ist nicht, wie lange Zeit angenommen wurde, konstitutiv, sondern sie wird auf der Ebene der Transkription zum einen durch Säure, zum anderen über die Verfügbarkeit des Urease-Kofaktors Nickel reguliert. In der vorliegenden Arbeit konnte die …
-
New insights into a complex host-pathogen interaction: mechanisms of Helicobacter pylori activation of NF-κB
Helicobacter pylori infection is the main cause of chronic gastritis, gastric ulcers and gastric cancer. The gram-negative spirochete, which infects more than half of the world’s population, is recognized by the International Agency for Research on Cancer as a group 1 carcinogen. The mechanism by …
-
Influence of chronic Helicobacter pylori infection on systemic and neuroinflammation and its impact on cognition
Helicobacter pylori is the major bacterial colonizer of the human stomach. It is estimated that approximately 50% of humans worldwide are chronically infected with this bacterium. Epidemiologically, H. pylori is recognized as the major risk factor and etiological agent of peptic ulcer disease and …
Page 1 of 5