Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 22 for “"H. contortus"”.
-
Comparative genomics of nematodes: Caenorhabditis elegans as a tool to study the Haemonchus contortus genome
… nematode parasite of small ruminants Haemonchus contortus is being sequenced at the Pathogen Sequencing Unit of the Wellcome Trust Sanger Institute, Cambridge, UK. Currently, in excess of 800 Mb of genomic sequence is available for this on-going project …
-
Characterizing Peripheral Cellular and Humoral Immune Responses to Haemonchus contortus in Sheep
… The most concerning of which is Haemonchus contortus; a blood-sucking nematode found in the abomasum of sheep. Worldwide anthelminthic resistance has prompted exploration of alternative methods of parasite control. Many studies have shown St. Croix hair sheep posses an immunologically …
-
Immunological evaluation of DNA vaccines against Haemonchus contortus and Toxoplasma gondii in sheep
… immune responses of DNA vaccines to Haemonchus contortus (H. contortus) and Toxoplasma gondii (T. gondii) in sheep. In the first experiment on H. contortus, sixty 12-month old ewe lambs were divided into six groups and vaccinated twice intramuscularly over a four week interval, using plasmid …
-
Characterization of the ACC-1 Family of cys-loop ligand gated ion channels from the parasitic nematode Haemonchus contortus.
… elegans) and parasitic (Haemonchus contortus) nematodes. However, their pharmacological properties in H. contortus have yet to be explored. My PhD thesis focused on identifying and characterizing the role of the ACC-1 family of receptors in H. contortus, using molecular cloning, …
-
Haemonchus contortus Infections in Alpacas and Sheep
The blood feeding nematode Haemonchus contortus infects the abomasum of small ruminants and compartment three (C-3) of camelids. Heavy infections may cause severe anemia and death. Alpacas were first introduced into the U.S. in the 1980s. Although not true ruminants, alpacas may become infected …
-
Isolation and partial characterization of three members of the GGR-1 family in the parasitic nematode Haemonchus contortus
Haemonchus contortus is a blood sucking parasitic nematode that infects ruminant animals. These parasites are of significant economic importance as they are estimated to cost the agricultural industry billions of dollars each year in management. Reliance and overuse of drugs has resulted in …
-
Investigation into the role of binding loop E on the function of the nematode cys-loop GABA receptor.
Haemonchus contortus is a parasitic nematode that infects the abomasum of ruminants. While several classes of anthelmintic drugs exist to control nematode infections, H. contortus is resistant to all of them. Therefore, novel drug targets such as ligand-gated chloride channels (LGCCs) need to be …
-
Molecular characterization of GABA receptor subunits from the parasitic nematode Haemonchus contortus
Haemonchus contortus is a parasitic nematode that is controlled by several nematocides which target ion channels. We have identified two H. contortus ion channel genes, Hcounc- 49B and C that encode two GABA-gated chloride channel subunits. Electrophysiological analysis shows that the Hco-UNC-49B …
-
The anthelmintic effect of Bacillus thuringiensis Cry5B on Haemonchus contortus in sheep
… that Cry5B would be effective against Haemonchus contortus, a highly pathogenic parasite, in sheep. Two experiments tested efficacy of Cry5B in sheep experimentally infected with H. contortus. In the first, a live genetically modified, asporogenous strain of B. thuringiensis expressing cytosolic …
-
Isolation and partial characterization of three acetylcholine-gated chloride channels in Haemonchus contortus
Haemonchus contortus is a parasitic nematode infecting ruminants causing anemia and poor health due to the parasite’s blood-feeding nature. The ability to manage infection has been confounded by the rapid development of antiparasitc drug resistance in H. contortus populations. The Cys-loop …
-
Genetics of resistance to Haemonchus contortus infections in sheep
Genetic control of resistance to H. contortus was assessed in 198 ewes and 386 lambs of 50% Dorset, 25% Rambouillet and 25% Finnsheep breeding in fall and spring over 2 yr. After deworming, lambs that were approximately 120 d old and ewes that had weaned their lambs at 60 d and dried off were …
-
Differential gene expression and immune regulatory mechanisms in parasite-resistant hair and susceptible wool sheep infected with the parasitic nematode, Haemonchus contortus
… producers, the parasitic nematode Haemonchus contortus is a major animal health concern. Caribbean hair sheep are more resistant than conventional wool breeds to this blood-feeding, abomasal parasite. Our objective was to determine differences in the immune response associated with …
-
Anthelmintic Screening, Phytochemical Analysis and Cytotoxicity Determination of the Indigenous Plants of the U.S.A. Northern Great Plains
<p><em>Haemonchus contortus</em> is a common, global, ruminant parasite. The major strategies for controlling this parasite involve the utilization of conventional anthelminthics. The appearance of anthelmintic resistance with the overuse of anthelmintics has created a greater need to look for the …
-
Effects of Dietary Immunomodulation on Parasite Load in Commercial Crossbred Lambs
… parasite susceptible sheep to clear a Haemonchus contortus infection. To test this hypothesis, Dorset-Texel lambs were fed a ration including CelmanaxRTM at 1g/hd/day for one week prior to receiving an experimental infection of 10,000 L3 stage H. contortus larvae; which continued until the …
-
The Pharmacological Characterization of Hco-UNC-49, a GABA-gated Chloride Channel from the Parasitic Nematode Haemonchus contortus
… infects ruminants worldwide. Hco-UNC-49 is a H. contortus GABA-gated chloride channel and is an orthologue to the UNC-49 channel from the free-living nematode Caenorhabditis elegans. Previous research by our group has shown that while the UNC-49 channels from the two nematodes share similar …
-
An examination of interacting residues in the GABA-gated ion channel UNC-49 within the parasitic nematode Haemonchus contortus
Haemonchus contortus is a blood-feeding parasitic nematode that infects ruminant animals around the world, including those with significant economic importance such as cattle, sheep, and goats. UNC-49 is a GABA-gated chloride channel found to be exclusive to nematodes which could be a viable future …
-
Immune related gene expression of parasite-resistant sheep during a Haemonchus contortus infection
… are becoming less effective. Haemonchus contortus is of particular interest because it feeds on blood, causing significant pathological problems in the host. Certain breeds of sheep, like St. Croix, are more naturally resistant to parasitism. However, the underlying mechanisms that result …
-
Examination of intramolecular interactions between residues of the cys-loop GABA receptor Hco-UNC-49 from Haemonchus contortus
Haemonchus contortus is a parasitic nematode known to infect ruminant animals such as sheep, goats and cattle. Despite several different anthelmintic drugs available to control the spread of this infection, H. contortus has shown resistance to all of them. In order to combat the infection, a novel …
-
Characterizing physiological and genetic differences in the early immune response to Haemonchus contortus in resistant and susceptible sheep
… susceptible sheep to infection with Haemonchus contortus during the peri-parturient period and larval stage of infection. Identification of immunological events resulting in parasite resistance in St. Croix hair sheep may provide better targets for differential gene expression analysis and …
-
Comparison of Immune Responses During Gastrointestinal Helminth Self-Cure Expulsion Between Resistant Gulf Coast Native and Susceptible Suffolk Sheep
… that are resistant or susceptible to Haemonchus contortus infection. Fifty-four Gulf Coast Native (resistant) and Suffolk (susceptible) lambs were allowed to acquire a natural GIN infection on pasture and were then randomly allocated into 4 groups. After being moved to parasite free housing for 2 …
Page 1 of 2