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Showing 1 to 20 of 24 for “"H+-ATPase"”.
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Regulation der vakuolären H(+)-ATPase durch reversible Proteinphosphorylierung
Die vakuoläre Protonen-ATPase, kurz V-ATPase, ist ein multimerer Enzymkomplex, der in fast jeder eukaryotischen Zelle zu finden ist und den aktiven elektrogenen Transport von Protonen über Membranen katalysiert. Die Aktivität der V-ATPase ist essentiell für eine Vielzahl physiologischer Prozesse. …
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Lst1p and Exp1p act in parallel pathways to export the plasma membrane H⁺-ATPase from the ER in S. cerevisiae
… we have selected Pma1p, the plasma membrane H+ ATPase of S. cerevisiae, as a model cargo protein. We found that efficient trafficking of Pma1p to the cell surface requires Lst1p, one of two yeast homologs of the COPII component Sec24p. We initially isolated LSTJ as one of a series of genes whose …
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Exp1p is a cargo adaptor for Sec24p mediated export the plasma membrane H+̳ ATPase from the ER in S. cerevisiae
… in the ER, we selected the plasma membrane H+ ATPase PMAJ as a model cargo protein. Pmalp is essential for creating an electrochemical gradient across the plasma membrane required for nutrient uptake and maintenance of cytosolic pH and accounts for ~25% of the total plasma membrane proteins. We …
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Regulation of Intracellular pH and Plasma Membrane Potential in Trypanosoma Cruzi and Trypanosoma Brucei
… was found to be regulated primarily by a H+-ATPase with support from a Cl- conductive channel in all stages and an inwardly directed K+ channel in the mammalian stages. The DeltaPsi in T. cruzi was found to be generated by a H+-ATPase in all stages however there were significant differences …
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Proton-atpase in fish gills
… proton excretion rate and determining the proton ATPase activity in gill tissue under different inhibitor treatments and environmental conditions. Evidence for the existence of anelectrogenic proton pump in fish gills was accumulated. Branchial proton excretion rate was estimated by measuring the …
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Atpase and Protein Kinase in Membranes From Corn Roots: Regulation of Tonoplast Atpase by Calmodulin or by Protein Kinase
A study was conducted to find if microsomal H('+)-ATPases from corn roots are regulated by Ca('2+)- or calmodulin (CaM)-dependent protein phosphorylation. This work included: (a) identifying the microsomal H('+)-ATPases; (b) characterizing protein kinase and phosphatase activities in microsomal …
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Regulation of acid-stimulated H+ secretion by Pyk2 and MAPK signaling pathways in the outer medullary collecting duct
… examined whether the Pyk2 and MAPK up-regulate ATPase mediated proton secretion in response to decreased pH in outer medullary collecting duct cells. Immunoblot analysis of phosphorylated Pyk2 (Tyr402), ERK1/2 (Thr202/Tyr204), and p38 (Thr180/Tyr182) was used to assay protein activation. To …
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Untersuchungen und Simulationen zur Koordination der Ionenflüsse bei der Schließzellbewegung in Vicia faba und Arabidopsis thaliana
… von etwa 35 pA festgestellt, vermutlich die H+-ATPase. - Die Abhängigkeiten des Anionenkanals, der einwärts und auswärts gleichrichtenden Kaliumkanäle und der Protonenpumpe von internen und externen Ionenkonzentrationen, dem pH-Wert und der Membranspannung wurden in einer biophysikalischen …
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Studien zur Expression und Lokalisation von P-Typ ATPasen aus Dunaliella bioculata
… der strukturellen Beschaffenheiten von P-Typ ATPasen, die die subzelluläre Verteilung bestimmen, sind sehr gering. Anhand von DBCA1, einer putativen Ca2+-ATPase und DBPMA1, einer putativen H+-ATPase aus Dunaliella bioculata sollte überprüft werden, ob N-terminale Sequenzbereiche, …
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Investigating the molecular mechanism whereby auxin modulates Arabidopsis thaliana growth under salinity stress conditions
… in the activation of the plasma membrane (PM) H+-ATPase pump and subsequent activation of expansion growth mediated by expansins. Additionally, the pump activation could enhance the proton motive force for ion transport across the PM, thereby affecting ion homeostasis during salt stress. The aim …
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Age-related changes in renal function, membrane metabolism, transporter activity and abundance in hypokalemic Fischer 344 x Brown-Norway F1 rats
… Western blot analysis of the al-subunit Na,K-ATPase and sodium hydrogen exchanger-1 (NHE-1) in BLM as well as NHE-3 in BBM was determined. Adenosine triphosphatase (ATPase) activity was measured in membrane vesicles and three microdissected segments of the nephron (proximal convoluted tubule …
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SNARE specificity in membrane protein traffic
… None of the Sp2s used had any effect on the H+-ATPase PMA2. These results offer evidence of a role for plasma membrane SNAREs in trafficking and anchoring of KAT1 to the plasma membrane.
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Identifying a role for WASH in the endocytic pathway of Dictyostelium discoideum
… coincides with removal of the Vacuolar H+ ATPase from lysosomal membranes, and suggests a possible role for WASH and actin in regulating the luminal pH of intracellular compartments.
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Osmoregulatory role of the intestine in fish physiology. Evolutionary, environmental, and toxicant implications
… crucial ion transporter proteins such as Na+/K+-ATPase (NKA), H+-ATPase (VHA), Na+:K+:2Clˉ cotransporter (NKCC), Na+:Clˉ (NCC). Moreover, we provide new insights on the molecular and physiological mechanisms in the most basal ion- and osmo- regulator, the sea lamprey (Petromyzon marinus), and in …
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V-ATPase regulation of Hypoxia Inducible transcription Factors
… I have explored the role of the vacuolar H+-ATPase (V-ATPase), the major proton pump for acidifying intracellular vesicles and facilitating lysosomal degradation, in regulating HIF-$\alpha$ turnover. Unbiased forward genetic screens in near-haploid human cells identified that disruption of …
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An Investigation into Neuroendocrine Regulators of Excretory Organs in the Adult Disease-Vector Mosquito, Aedes aegypti
… CAPA-mediated inhibition promotes V-type H+-ATPase (VA) disassembly, reducing the driving force of DH31-stimulated secretion. Post-blood feeding, DH31 peptides are immediately released into the female haemolymph to promote natriuresis and diuresis while CAPA peptides are released shortly …
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Neural Mechanisms of Decision-Making: Modulation of the Feeding Neural Network by Nitric Oxide and Serotonin in the Predatory Marine Snail Pleurobranchaea Californica
… may perturb intracellular pH through Ca2+/H + ATPase homeostatic regulation of Ca2+. Type 1 I Na,cAMP amplitudes are sensitive to pH. Additionally, NO enhancement Of INa,cAMP is suppressed with injection of either Ca2+ chelators or pH buffers. 5-HT positively modulates feeding in …
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Functional and Mechanistic Analysis of Protein Degradation by Human Cytomegalovirus to Uncover Viral Immune Evasion Mechanisms
… DMXL1 interacts with the vacuolar-type H+-ATPase to regulate endosomal acidification, with implications for endosomal trafficking, autophagy, immune signalling and many other cellular processes. The viral gene responsible for downregulation of DMXL1 was identified as pUS33A, which may …
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Peroxidação de lipídios em membranas e tecidos de dois cultivares de sorgo (Sorghum bicolor (L.) Moench) com tolerância diferencial ao alumínio
… do Al. Na presença do Al, a atividade da H + -ATPase reduziu no sistema radicular das plantas, mas, principalmente nas membranas plasmáticas provenientes dos ápices das raízes do cultivar tolerante. Dentre as principais modificações verificadas sobre a composição de ácidos graxos das membranas …
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Räumliche und zeitliche Aspekte der intrazellulären pH-Regulation in Epithelien
… wird durch eine apikal lokalisierte vakuoläre H+-ATPase (V-ATPase) energetisiert. Stimulierung der Speicheldrüsen mit 5-HT aktiviert die apikale V-ATPase, die Protonen aus der Zelle in das Drüsenlumen transportiert. Trotz des auswärts gerichteten Protonentransportes führt die 5-HT-Stimulierung …
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