Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Gynaecology, Obstetrics and Reproductive Medicine"”.
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New predictive and diagnostic biomarkers for preeclampsia
… 3-8% of all pregnancies leading to maternal- and fetal morbidity and mortality. The etiology is still not known in detail. Previous findings have shown an up regulation of the genes coding for fetal hemoglobin (HbF) in preeclamptic placentas. The cell-free HbF protein was shown to be …
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Ultrasound Studies of Caesarean Hysterotomy Scars
… of non-pregnant women could be used to visualize and assess caesarean hysterotomy scars, and to evaluate the risk of uterine rupture in subsequent pregnancies. The diagnostic value of transvaginal ultrasound for correct evaluation of caesarean hysterotomy scars was determined, and the prevalence …
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Maternal diabetes during pregnancy – obstetrical considerations and long term effects
… detrimental health impacts on both the mother and fetus, and include increased risks of cardiac malformations, cesarean section (CS), and asphyxia. The aim of the thesis was to investigate short and long term cardiac effects after fetal exposure to DM, investigate the ability of a 5 minute …
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The use of ultrasound in the prediction of endometrial cancer in women with postmenopausal bleeding
… thesis was to identify the ultrasound methods and ultrasound features that are most useful for the prediction of endometrial cancer in patients with postmenopausal bleeding and sonographic endometrial thickness 4.5 mm or more. The grey-scale ultrasound variable that best predicted malignancy …
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Reproductive function in young Swedish men - Time trend, prenatal and adult exposure to smoking and phthalates
A decrease in male reproductive function, including sperm counts, during the second half of the 20th century, has been postulated. During this period, testicular cancer has increased several-fold. Environmental and lifestyle-related factors have been proposed as explanations for a possible negative …
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Birth after Caesarean Section
… CS carries the largest risks for mother and child. We wanted to investigate for which women and infants it would be safest to recommend an ERCS or a TOL. We assumed, that underlying conditions/indications for the first CS performed would often recur in the second pregnancy and be …
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The uPA receptor in ovarian cancer. Regulation by EGF and the estrogen responsive membrane receptor GPR30. Soluble uPAR in diagnosis and prognosis.
… which is part of the malignant phenotype, and the uPA receptor (uPAR) plays a central role in cell migration. We studied the role of EGF and estrogen on cell migration and uPAR expression in ovarian cancer cell lines. We also analyzed the diagnostic and prognostic value of cleaved forms of …
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Pitfalls in Interpreting Umbilical Cord Blood Gases and Lactate at Birth
… an objective measure of the fetus’ exposure to and ability to handle hypoxia. The objective of this thesis was to clarify some of the methodological pitfalls in interpreting umbilical cord blood gases and lactate values at birth. Study I pinpoints the methodological confounding in calculating …
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Cervical cancer studies on prevention and treatment
… of a screening program. Cervical cancer and dysplastic lesions in the cervix are caused by infection by the Human Papilloma Virus, mainly HPV 16 and 18. An alternative to cytological screening is screening for HPV DNA. The aim of this thesis was to analyze the screening history of women …
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Fetal Cardiac Function and Venous Circulation - Experiences with Velocity Vector Imaging
… (IUGR) is a common complication of pregnany and severe IUGR, with ensuing fetal hypoxia is an important cause of perinatal mortality and morbidity. Doppler studies of fetal and maternal vessels are routinely used for fetal surveillance and alterations in fetal venous blood flow has been …
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Testicular cancer; gonadal, sexual and psychological aspects of the disease and its treatment.
… (TGCC) patients have dramatically increased and more than 95 % are cured. The question of quality of life of the survivors is, therefore, important. The TGCC treatment, and thereby its side-effects may vary. A contributing factor to this variation is also genetically determined inter-subject …
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Endocrine markers of ovarian function: Clinical and biological aspects with focus on Anti Müllerian hormone
Declining birthrates and infertility are now a common problem in the Western World. Due to the tendency to postpone childbearing an increasing age of women who consider motherhood is generally seen. A factor closely related to female fertility is the ovarian reserve, a term used to designate both …
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Gene and Protein Profiling of the Preeclamptic Placenta
… State-of-the-art methodology was used to screen and profile the placenta, gene and protein expression, for changes related to preeclampsia (PE) and cases with increased resistance in the uterine arteries. Women with increased resistance in the uterine arteries have increased risk of developing …
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The impact of genetic, environmental and life-style factors on male reproductive function
… significant geographical differences in male reproductive function have been observed. In Finland, the sperm concentration was found to be substantially higher than in Denmark. In parallel, the incidence of testicular cancer (TC) and of congenital malformations of male genital organs is …
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Gestational diabetes mellitus – prevalence in southern Sweden and risk factors for subsequent diabetes
… with risks during pregnancy, during delivery, and in later life with a substantial risk of subsequent diabetes. The worldwide prevalence of GDM is increasing, but varies with differences in diagnostic methods and population characteristics. Results: Capillary glucose concentrations were found …
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Male Subfertility and Prostate Cancer Risk: Epidemiological and Genetic Studies
Androgen action plays a pivotal role in male reproductive tract physiology and pathology. The androgen receptor (AR) gene harbors two codon repeat tracts: the CAG and GGN repeats, encoding corresponding amino acid sequences of variable length; the polyglutamine and polyglycine stretches, …
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Hematopoietic stem and progenitor cells and potentials for application in fetal cell replacement therapy
… for a number of inborn immunologic, hematologic and metabolic disorders. IUHCT represents the method through which variable amounts of natural or genetically modified hematopoietic cells can be transferred to the fetal recipient in hope of correcting the disorder and preventing postnatal …
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GENERAL ORAL GLUCOSE TOLERANCE TEST DURING PREGNANCY, AN OPPORTUNITY FOR IMPROVED PREGNANCY OUTCOME AND IMPROVED FUTURE HEALTH.
… with a risk of adverse pregnancy outcome and is a predictor of subsequent diabetes. The aims of this work were to describe a reliable routine to diagnose abnormal glucose tolerance during pregnancy, to investigate women’s opinions of the specialist care provided, to determine the …
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Studies on genetic aberrations as possible predictors of the outcome of assisted reproduction
… (WHO) in regard to sperm concentration, motility and morphology are, however, poor predictors of fertility. In about half of the involuntarily childless couples the causes are solely or partly male related. In 60-75% of cases the aetiology of reduced semen quality remains unexplained and is …
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Genetic, environmental and life-style effects on androgen receptor function
Androgens regulate male reproductive function and their effects are mediated through the androgen receptor (AR). The AR gene contains a polymorphic CAG repeat, encoding a stretch of glutamines, affecting the transcriptional activity of the AR. Prostate specific antigen (PSA) is a downstream target …
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