Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Gut-homing"”.
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Phenotype and function of intestinal CD103+ dendritic cells
… DCs have been shown to promote induction of both gut homing receptors on responding T cells and differentiation of FoxP3+ regulatory T cells via the vitamin A metabolite retinoic acid (RA). Another intestinal DC/macrophage subset, expressing the chemokine receptor CX3CR1+ has been suggested to …
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The ontogeny and function of intestinal dendritic cells
… throughout the intestinal lamina propria and in gut associated lymphoid tissues (GALT) of mice and humans. Intestinal cDCs migrate constitutively to mesenteric lymph nodes (MLNs) where they present luminal derived antigen to T cells. Intestinal derived cDCs are thought to play an major role in …
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Non-conventional Regulation of Treg Development and Function
… in human IBD patients. The role of the gut homing molecule CCR9 in IBD is poorly understood. CCR9 is a potential drug target that is currently being investigated due to the potential to disrupt migration of pathogenic T cells to the gut. However clinical trials indicate a protracted …
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Primary sclerosing cholangitis: from genetic risk to disease biology
… blood T-cell subsets (including the rare CCR9+ gut-homing T-cells) from 80 patients with PSC and IBD. With colocalisation, I assign causal genes to five PSC risk loci, and assign other epigenetic regulatory features including methylation or histone modification, to six risk loci. Statistical …
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Cellular immune ontogeny and birth transcriptome in HIV-exposed uninfected infants
… activation directly ex vivo, markers of T cell gut homing and proliferation—a proxy for HIV susceptibility, and (ii) vaccine-induced Th1 cytokine expression (IFN-, TNF-a, IL-2) and memory maturation. Cytokine responses were profiled for polyfunctionality by SPICE analysis and complemented by the …