Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Gut permeability"”.
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The effect of oral glutamine supplementation on gut permeability and heat shock protein regulation in runners with a history of gastrointestinal distress
Gastrointestinal (GI) permeability increases during high intensity exercise leading to endotoxin leakage, and a pro-inflammatory immune response. The purpose of this study are to assess whether oral glutamine supplementation (1) reduces exercise induced permeability through up-regulation of the …
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Human Cytochrome P450 3A4 Over-Expressing IEC-18 and MDCK Cell Lines as an In-Vitro Model to Assess Gut Permeability and the Enzyme Metabolism
… drug absorption and first-pass metabolism in the gut and the liver. Mammalian cells lines such as MDCK and Caco-2 are commonly employed to assess drug permeability but they lack or have low expression level of drug metabolism enzyme expression such as CYP3A4, which contributes to significant …
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Skeletal muscle metabolic adaptations in response to an acute high fat diet
… capacity, insulin resistance, increased gut permeability, inflammation, and other risk factors often preceding metabolic disease states. The disruption of gut function leads to gut permeability and increases endotoxins released into circulation. Endotoxins have been shown to play an …
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The Effects of Acute Consumption and Chronic Supplementation of Cocoa on Overweight and Obese Adults at Risk of Developing Diabetes
… improve insulin sensitivity, and decrease gut permeability in animals and humans, but it is unknown if this occurs in adults with prediabetes. Therefore, we first hypothesized that an acute dose of cocoa would reduce postprandial glucose and enhance insulin and incretin hormone responses to …
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Effects of Acute Alcohol Exposure on Post Burn Intestinal Immunity: Role of IL-23
… injury. Several lines of evidence suggest that gut pathogens and/or their products may play a role in the development of sepsis and multiple organ failure reported in burn and trauma patients. In line with this hypothesis, our laboratory has demonstrated increased intestinal tissue damage, …
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Novel effects of Prefoldin Pathway on Intestinal Homeostasis via Dietary Restriction in Drosophila melanogaster
… loss of these subunits would increase intestinal permeability, resulting in a loss of longevity. Downregulation of these these subunits would result in novel activation of established pathways to increase permeability. The model organism, <em>Drosophila melanogaster</em> (fruit fly)<em>,</em> has …
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Experimental Approaches to Understand and Control Salmonella Infection in Poultry
… were isolated and evaluated for decreasing the gut permeability in Caco-2 cell lines. The result from animal experiments indicated that a combined batch culture of 3 selected strains showed significant efficacy in controlling intestinal colonization of ST in neonatal turkey poults.</p>
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The influence of a dietary supplement (NDS Baseline Probiotic) on the gastrointestinal quality and physical performance of endurance runners
… (IgG, IgA and IgM in EDTA-plasma) and to measure gut permeability (urinary lactulose and rhamnose excretion; dosage: 5g lactulose and 0,5g rhamnose) before and after exercise stress tests (field test: 60 min running at 80% VO2max). <br> <br>Results: <br>The GIQLI improved over the whole …
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Colonic metabolism of dietary grape seed extract: Analytical method development, effect on tight-junction proteins, tissue accumulation, and pan-colonic pharmacokinetics
… grape seed extract increased the expression of gut junction protein occludin and reduced levels of fecal calprotectin, which suggests an improvement of gut barrier integrity and a potential modulation of endotoxemia. Additionally, chronic supplementation of the diet with flavanols did not …
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Effects of Exercise Intensity, Modality and Environment on Gastrointestinal Permeability, Damage and Symptomology in Healthy Males.
… increases gastrointestinal (GI) symptomology and permeability potentially effecting performance and recovery. This thesis addresses the issues of how exercise intensity, modality and pattern of exercise will impact upon GI permeability, damage and symptomology expression. Further it will examine …
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Evaluating the effect of dietary changes and management strategies to feedlot cattle during the adaptation and finishing phase on performance, carcass characteristics and the rumen microbiome
… type on growth performance and indicators of gut permeability when fed with or without tylosin. Angus and Angus × Simmental heifers (N = 120; 188 ± 2.6 kg) were blocked by initial BW and alloted to 8 pens. Pens were randomly assigned to either be fed tylosin (T+) or no tylosin (T-) on d 0. …
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The neurodevelopmental impact of stress and inflammation during pregnancy: influence of the maternal microbiome and gut health
… was based on inflammatory markers, measures of gut permeability, and tryptophan metabolism. Exposure to serum from “high-stress” pregnant women reduced neurite length in partially differentiated SH-SY5Y cells. This potentially harmful effect was due in part to phosphorylation of NF-κB p65 …
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Impact of dietary modification on aflatoxicosis in poultry
… in 21 d broiler chicks. Additionally, impaired gut barrier, increased endogenous N loss, and reduced energy, N, and amino acid digestibility, and altered mRNA expression of intestinal tight junction proteins and transporters are also consequences of AFB1 exposure at 1.5 mg/kg in broilers. …
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Development of in vitro infant intestinal models to assess responses to infant formulae
… are intimately linked, with the neonatal gut characterized by higher permeability than in adults. The aim of this thesis was to develop and validate in vitro models that mimic the infant intestinal barrier. Once developed, these models were employed to study epithelial responses to …
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Further elucidating the effects of ruminal and hindgut acidosis on the ruminant animal
… was to determine the effects of induced hindgut acidosis in sheep on cecal pH, ruminal fermentation, and gut permeability. Eleven ruminally and cecally cannulated ewes (49 ± 4 kg) were assigned to one of two treatments: control (CON; n = 5) or induced hindgut acidosis (HGA; n = 6). To induce …
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Unravelling the role of tryptophan metabolism in the microbiota-gut-brain axis: focus on the effects of stress and exercise
The involvement of the microbiota-gut-brain axis communication in brain function and behaviour has enabled a paradigm shift in neuroscience, neurogastroenterology and psychiatric research. Two key routes of this bidirectional communication are impaired in stress-related disorders: the …
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Feeding peroxidized soybean oil to finishing pigs: Effects on performance, nutrient digestibility, carcass characteristics, and the shelf-life of loin chops and commercially manufactured bacon
… subsequently measured in the urine to evaluate gut permeability, while markers of oxidative stress were evaluated in plasma, urine, and liver. At 82 d pigs were slaughtered and hot carcass weight (HCW) and liver weights were recorded. Carcass characteristics and fresh loin quality were evaluated …
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Using prophylactics to improve resistance against Enterobacteriaceae in chickens
… actively promote immunotolerance in the chicken gut, which prevents antibacterial host responses and subsequently results in fecal Salmonella shedding and contamination of poultry products. Thus, novel prophylactics which can stimulate host intestinal responses and overcome these immunotolerant …
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Rac1 and IRE1 are Required to Prevent Early Loss of Intestinal Homeostasis in Drosophila melanogaster
<p>No abstract available</p>
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Effects of fructan source and degree of polymerization on intestinal barrier function and histomorphology characteristics in obese C57BL/6 mice
Obesity is linked to increased intestinal permeability that may contribute to low grade inflammation. Fructan prebiotics have been demonstrated to increase intestinal resistance and decrease systemic inflammation. The objective of this study was to test the effects of prebiotics on intestinal …