Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Gut microbiome composition"”.
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Prebiotic supplementation with inulin and exercise influence gut microbiome composition and metabolic health
… lack of exercise, and detrimental changes to the gut microbiome. Dietary intake and exercise are modifiable lifestyle factors for reducing T2D risk; however, several questions remain unanswered related to the efficacy and role of prebiotics and exercise, and their respective influences on gut …
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Effects of 5��-Dihydrotestosterone (DHT) on Mouse Gut Microbiome– A Study of Sex Differences and Hormonal Effects on Gut Microbiome Composition
… have placed a higher significance on the role of gut microbiome in T1D pathogenesis. Furthermore, diabetic mouse models have shown higher incidence of T1D in females compared to males, attributed to the differences in gut microbial community structure. Interestingly, female mouse models elicit …
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UNVEIL THE CONNECTION BETWEEN METABOLIC AND INFLAMMATORY CARDIOVASCULAR RISK FOSTERED BY NUTRIENT INTAKES.
… intakes, and the potential implication of gut microbiome in these connections. In this context, we aimed to unveil the connection between the metabolic and inflammatory cardiovascular risk fostered by nutrient intakes. To achieve our aim the following tasks were settled: (i) deepen the …
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SEX-DEPENDENT GUT MICROBIOME DIFFERENCES IN A TRANSGENIC MOUSE MODEL OF AUTISM
… Disorder (ASD). Changes in the diversity of the gut flora, and co-occurring gastrointestinal pathologies, have been consistently noted in studies of individuals with ASD. A number of mechanisms exist through which sAPPα overexpression may exert an influence on the initial development of the gut …
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16S rRNA sequence analysis of silver carp microbial community in eDNA water samples
… in making this assay more robust. A specific gut microbe within the phylum Fusobacteria has been identified as unique to fish species and Silver Carp specifically. The ability to detect these species alongside the Silver Carp DNA would establish two lines of evidence to determine the presence …
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Integrative Analysis of the Human Gut Phageome Using a Metagenomics Approach
… microbial communities. Given the impact of the gut microbiome composition and function on human health, there is a growing focus on phages that inhabit the gut ecosystem. However, the extent of viral diversity, biology, and worldwide epidemiology of gut phages remain largely unknown. In this …
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The gut microbiota in depression
The accruing data linking the gut microbiota to the development and function of the central nervous system has been proposed as a paradigm shift in neuroscience. Neuroimmune, neuroendocrine and neural communication pathways exist between host and microbe. These pathways are components of the …
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Implications of Dietary Fiber and Fermentable Carbohydrates on Gut Health and Intestinal Microbial Ecology of the Dog
… and individual fermentable carbohydrates on gut health and gut microbial composition of dogs. Three experiments were conducted to (1) evaluate how supplemental mannanoligosaccharides (MOS) affect the dog gut and specific gut microbiota; (2) to evaluate if oligosaccharides like MOS and …
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The microbiome-gut-brain axis in preclinical alpha-synuclein models of Parkinson's disease
… within the enteric nervous system and the gut microbiome composition is altered in PD. A gut-origin of α-synuclein pathology in PD has been proposed, but is debated. Therefore, there is an unmet need to develop preclinical models to interrogate the role of the microbiome-gut-brain-axis in …
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Interactions Between Gut Microbial Composition, Mucosal Immunity and Metabolism
While evidence that the intestinal microbiome contributes to host health and disease has rapidly developed, the causal mechanisms that link these microbes to disease are largely elusive. The goal of this project was to explore the complex crosstalk between the microbiome and the immune system using …
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Bayesian Balance Regression And Mediation Analysis For Microbiome Compositional Data
In microbiome studies, 16S rRNA sequencing is commonly used to quantify the taxonomic abun- dance of a microbial community. The resulting data are counts of amplicons. However, the total count is not informative because of the sampling, sample preparation and sequencing processes. These counts are …
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Closing the fibre gap in refined cereal product – quality and health
… such as glycemia, energy intake, satiety, and gut microbiome composition and function.
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Investigations on the role of the gut microbiota in hippocampal neuroplasticity and behaviour throughout the lifespan
… are not fully known. In parallel, the gut microbiome is highly sensitive to diet and stressful life events, however it is unknown whether the gut microbiota is an active mediator in the impact of these factors on hippocampal neurogenesis. Furthermore, the gut microbiota is initially …
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Wolbachia colonization in drosophila midguts and its effects on intestinal stem cells
… into the insect vector. This occurs trough the gut epithelium, highlighting the importance of understanding the interaction of this tissue with microorganisms. We have recently shown that Wolbachia colonizes the Drosophila gut epithelium and affects the gut microbiome composition. Wolbachia’s …
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Interplay Between Tryptophan Metabolites and the Virulence Factors of Enteric Pathogens
The human gut consists of a complex milieu of several small molecules that helps in shaping its overall chemistry and biogeography. Trillions of bacteria, collectively known as the gut microbiota, colonize this landscape and occupy a specific niche. Small molecules derived from diet, gut microbial …
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A comparative evaluation of the gastrointestinal immune response of the modern and heritage broiler chicken
… Chickens lack encapsulated lymph nodes, so the gut associated lymphoid tissues (GALT) and intestinal immune cells contribute significantly to the immune response. Furthermore, the gut is the point of intersection of metabolism, immune responses, and exposure to external antigens. Therefore, the …
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Microbes for life; investigating the effects of oral administration of Lactobacillus mucosae DPC 6426 on cardiometabolic parameters
… 21st century. This thesis outlines the role the gut microbiome has in the progression of the associated risk factors and alternative therapeutic approaches for cardiovascular disease prevention. In Chapter 1, the importance of the gut microbiome and use of clinical scale models are discussed with …
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Unraveling Host-Gut Microbiota Dialogue and Its Impact On Response to Immune Checkpoint Blockade
… aims to improve clinical response of ICB is the gut microbiome. The microbiome is defined as the community of commensal bacteria, fungi, and viruses, both good and bad, that co-habits the human body. This dissertation is focused on the role of gut microbiome in shaping response and resistance to …
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Oxidative Stress and Inflammation in the Heterogeneity of Metabolic Health
… Dietary patterns, physical activity, and gut microbiota composition were also evaluated. The findings indicate that metabolic health status explains differences in inflammatory and oxidative stress profiles more effectively than BMI alone. Individuals with comparable BMI values showed …