Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Gut inflammation"”.
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Identify the regulatory roles of intestinal secretory cell lineages during gut inflammation
… and enteroendocrine cells (EECs), in colonic inflammation, revealing novel cellular and molecular dynamics. The initial study utilized IEC-specific Hnrnp I knockout mice to demonstrate significant upregulation of pro-inflammatory cytokines such as Il1β, Cxcl1, and Ccl2. This animal model was …
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Engineered E. Coli That Detect and Respond to Gut Inflammation Through Nitric Oxide Sensing
… by allowing E. coli to reliably detect and treat inflammation in patients with inflammatory bowel disease, but the circuit described herein now serves as the proof-of-concept for both bacterial sensing of mammalian inflammation and for the use of DNA recombinases to translate transient …
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Host-microbe interactions in the inflamed gut
… luminal antigens to the host mucosa triggering inflammation. We tested whether the probiotic Enterococcus faecium NCIMB 10415 (NCIMB) is capable of reducing chronic gut inflammation by changing the existing gut microbiota composition and aimed to identify mechanisms that are involved in possible …
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From Flare to Repair: Commensal Bacteria's Influence on Inflammation and Wound Healing
… the immune system is well established, and the gut microbiota has been recognized as a critical contributor to various diseases such as inflammatory bowel disease (IBD), cancer, and even extra-intestinal inflammatory manifestations. Disruptions of the microbiome, known as dysbiosis, can affect …
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Role of the Gut Microbiome in Cancer Immunotherapy Efficacy and Side Effects
Gut microbiome plays an important role in host health and disease, influencing various physiological processes, including immune responses. Its role becomes particularly significant in cancer immunotherapy, where the microbiome can shape both the efficacy and side effects of immune checkpoint …
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SYNDROMIC HIDRADENITIS SUPPURATIVA: GENOTYPE-PHENOTYPE CORRELATION THROUGH WHOLE-EXOME SEQUENCING IN 10 UNRELATED PATIENTS
… been identified based on presence/absence of gut and joint inflammation. Four PASH patients who had also gut inflammation showed three different variants in NOD2 gene, two variants in OTULIN, and a variant in GJB2, respectively. Three PAPASH and three PASH/SAPHO overlapping patients who had …
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Host parasite interaction in a mouse model of inflammatory bowel disease
… little is known immunologically about how gutparasites alter IBD progression. We have used mdrla KO mice on an FVB background toinvestigate any change in progression of colitis in mice infected with Trichuris muris. Pglycoprotein(PGP), present in the apical membrane of gut epithelial cells, …
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Strategies to maximize feed quality and poultry performance
… that phytase inclusion may help decrease gut inflammation and subsequent immune response caused by phytate phosphorus (P); therefore, other objectives of research conducted in Chapter 5 were to assess the effect of increasing phytase inclusion on D40 gut inflammation via ileal mRNA …
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Pathogenic Mechanisms Underlying Immune Dysregulation Associated To Hypomorphic RAG2 Mutation: Role Of Microbiota At Mucosal Interfaces
… environmental interfaces such as the skin and gut, leading to distinctive early onset erythroderma and protracted diarrhea. However, the complete comprehension of the molecular and cellular mechanisms underlying such autoimmune-like manifestations in OS is still puzzling. Furthermore, the role …
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Composición de la microbiota en pacientes pediátricos con déficit de hormona de crecimiento antes y después de recibir tratamiento con hormona de crecimiento
… body, the most numerous and complex being the gut. Alterations in the composition and functionality of the microbiota (dysbiosis) have been associated with various pathologies. Among the different functions of the microbiota, its role in growth is particularly important. Indeed, several studies …
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Alergia alimentar - temporalidade X antigenicidade
… peanuts they become tolerant, and do not develop gut alterations. However, if they are immunized with peanut extract prior to a challenge diet containing peanuts they develop a chronic inflammation of the gut. AIMS: evaluate the influence of oral tolerance in a subsequent immunization to a …
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Discovering the mechanism of action of nutritional therapy and evolving an innovative formula for the treatment of Crohn's disease
… complete polymeric formula (PF), can suppress gut inflammation and induce remission in active Crohn disease (CD). However, PF’s used for EEN therapy were developed for nutritional support and not for therapeutic roles. The aim of this thesis was to identify and describe components of PF that …
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Markers and outcome measures in chronic immune mediated artrhritis: from association studies to prediction models.
… disease. Inversely, the association between gut inflammation in SpA and carriage of CARD15 polymorphisms was explored. Also, an association between carriage of CARD15 polymorphisms and anti-Saccharomyces cerevisiae antibodies in Crohn’s disease patients is demonstrated. The diagnostic …
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The role of genetic alterations in the gut-joint axis of Crohn's disease and Spondyloarthropathies
… is associated with the presence of chonic gut inflammation, similar to CD. Whether these genetic variants in CD and SpA play a direct role in the origin of inflammation at distance of the gut, is uncertain. The frequent association between axial involvement, peripheral arthritis and uveitis …
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Of Sex, Gut and Brain: Functional Studies in a Mouse Model of Amyotrophic Lateral Sclerosis-Frontotemporal Dementia
… these mice exhibit an abnormally enlarged gut, suggesting an involvement of the gut microbiota (i.e., the collective microorganisms such as bacteria, viruses, and fungi that populate the organ and regulate its physiology) in disease. Emerging studies suggest that gut microbiota is a key …
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Regulation of Visceral Nociception by GPR35
… organs or by mediators released in response to gut inflammation. Pain management in these conditions is challenging due to the side effects associated with commonly used analgesics, and so a significant unmet clinical need exists for the development of new visceral analgesics. GPR35 is a G- …
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Exploring the gut microbiome: metaproteome analysis of HIV-exposed uninfected infants
… to disease and have weaker immune responses. The gut microbiome plays a pivotal role in human health by aiding in metabolism, nutrient availability and immune development and function. The mucosal immune system and microbiome work in synergy to maintain host immunity and balance for optimal host …
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Lipid-based nutrient supplement to address child undernutrition and enteric parasitic infections in India
… undernutrition such as parasitic infections and gut inflammation in children. The objective of this study was to develop advanced LNS 2.0 with improved shelf stability, consumer acceptability, and antiparasitic activity via added oregano essential oil (OEO) bioactives. LNS were formulated using …
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Investigating the role of IgG and Fcγ receptors in intestinal inflammation
… suggesting that IgG may be important during gut inflammation. IBD is a chronic relapsing condition with two major subtypes, Crohn’s disease (CD) and ulcerative colitis (UC), both driven by aberrant immune responses to commensals. In the first part of this thesis, we sought to investigate …
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