Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Gut hormones"”.
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Exploring the function and sensing mechanisms of human enteroendocrine cells using intestinal organoids
The gut is the largest endocrine organ in our body thanks to the presence of hormone-releasing enteroendocrine cells (EECs), which represent only around 1% of the total gut epithelium. Gut hormones are released in response to cues of different natures to regulate several physiological events, such …
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Characterisation of human enteroendocrine cells in organoid models
Gut hormones secreted by enteroendocrine cells (EECs) coordinate the postprandial response to a meal by regulating digestion, absorption, circulating nutrient availability and satiety. EECs are specialised endocrine cells scattered throughout the gastrointestinal epithelium that release hormones in …
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Studies on aspects of Autonomic Neuropathy in non Insulin dependent Diabetes
… release of a number of gastrointestinal hormones. It is therefore possible that autonomic dysfunction may be associated with altered gastrointestinal hormone release and indeed various studies have revealed abnormalities in t he release of these peptides in diabetes mellitus. The prime …
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Mechanisms underlying monosaccharide stimulated incretin hormone secretion from the intestine
… prevalence worldwide. Drugs which mimic the gut hormone glucagon-like peptide-1 (GLP-1), e.g. Semaglutide, are currently the most effective obesity and T2D therapeutics, activating GLP-1 receptors in the pancreas and brain to improve blood glucose and appetite control. Due to the therapeutic …
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The metabolic sequelae of oesophago-gastric resection
… symptoms. By profiling and challenging the gut hormone axis in healthy volunteers and patients who had undergone total or subtotal gastrectomy, or oesophagectomy, this thesis explores the possible causative mechanisms for the challenges faced by this patient population. In the surgical …
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Delayed gastric emptying in Ivor Lewis Gastro-oesophagectomy
… test after pyloric dilatation. Analyses of gut hormones(GH): glucagon-like-peptide-1(GLP-1) and peptide tyrosine tyrosine(PYY), were conducted based on DGE status and treatment. Post-operative DGE-related symptoms(PODRS) were assessed using a modified questionnaire. The algorithm had …
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Regulation of Energy Balance by Dietary Protein
… of dietary protein in the secretion of metabolic hormones has not been well-studied in cats. In this thesis, the effects of protein-restricted diets, tryptophan or histidine-restricted diets, and diets with excess protein on energy intake, energy expenditure, body weight and composition, gut …
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Central mechanisms underlying the synergistic anorectic effect of CCK and GLP-1 combination therapy
… (CCK) and Glucagon-like peptide-1 (GLP-1) are gut hormones produced in response to meal ingestion that promote satiety and meal termination. Co-infusion of long-acting CCK and GLP-1 receptor agonists have been shown to synergistically reduce food intake and body-weight in diet-induced obese …
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Neurobiological and metabolic mechanisms of binge-eating in anorexia and bulimia nervosa
… the impact of acute, psychological stress on gut hormones, endocrine responses, and inhibitory control in women acutely ill with the binge-eating and purging subtype of anorexia nervosa, bulimia nervosa and matched controls. Chapters 3 through 5 report the results of this study. Chapter 3 …
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Influence of Pre-meal Inulin Consumption on Energy Intake in Overweight and Obese Middle-aged and Older Adults: A Pilot Study
… impact on the composition and activity of the gut microbiota. Specifically, inulin-type fructans (ITF) including inulin, oligosaccharides, and fructooligosaccharides have been generating interest in the prebiotic area in the past two decades. A lot of attention has been directed at weight …
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Generation and use of new tools for the characterisation of gut hormone receptors
Enteroendocrine hormones released from the intestine following food intake have several roles in the control of metabolism, some of which are exploited therapeutically for the treatment of type 2 diabetes. Within this thesis, focus has been on the receptors of the gut hormones glucagon-like …
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Identification of a Dual-Action Small Molecule with Potent Anti-diabetic and Anti-obesity Activity
… glycemic control in T2D patients. Incretins are gut hormones that possess potent insulinotropic action, which have drawn considerable attention in research and developing treatment strategy for T2D. Specifically, glucagon like peptide 1 (GLP-1), the most important incretin that is secreted from …
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Optimising the management of new-onset prediabetes/diabetes after acute pancreatitis
… part includes studies that investigated the gut hormone profile after a mixed-meal test to identify a distinguishing biomarker for NOPAP/NODAP (comparator groups - type 2 prediabetes/diabetes and health), and the factors associated with that biomarker. The second part includes studies that …
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Molecular mechanism of magnesium transport in epithelial cells
… secretions are controlled mainly by the gut hormones and by the neurotransmitters released by the autonomic nervous system. The hormones and neurotransmitters (secretagogues) utilise different intracellular mediators to elicit enzyme and fluid secretion. One particular mediator is the …
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A novel nutritional approach to the management of type 2 diabetes: effects of nutritional preloads on postprandial blood glucose and gastric emptying in type 2 diabetes mellitus
… intestine, mediated in part by the secretion of gut hormones. Gastric emptying is often disordered in people with type 2 diabetes; the emptying of solids and/or nutrient liquids is abnormally delayed in up to 30-50% with patients with longstanding type 2 diabetes, while gastric emptying may be …
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Mechanisms of insulin resistance and β - cell failure in type 2 diabetes. Effective diet against o minous octet
Úvod a cíle: Dietní intervence je pilířem léčby diabetu 2. typu (T2D). Vegetariánská strava je zajímavou alternativou. Cíle naší studie byly následující: 1. Porovnat účinky vegetariánské a konvenční diabetické diety se srovnatelnou kalorickou restrikcí na inzulínovou rezistenci, objem viscerálního …