Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Gut flora"”.
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Elucidation of an oral drug delivery mechanism to the mammalian gastrointestinal tract via an engineered T4 phage
Current treatments of gastrointestinal (gut) disease are limited by high dosing frequency, patient noncompliance, and complications circumventing the harsh conditions of the upper gastrointestinal tract (e.g. stomach), leading to therapeutic degradation. Bacterial cells were previously explored as …
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Integrity of the Barrier Epithelium in Drosophila Gut is Mediated by Factors That Regulate Intestinal Stem Cell Activity
… specific regulatory genes, and proposing gut barrier function–specific genes as regulators of commensal bacteria density. The results from this project have shown that intestinal stem cells (ISCs) respond systemically in the presence of autonomously induced, visceral muscle (VM)-localized …
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The role of B cells in the amplification and in the regulation of transplant rejection.
… A difference in the gut flora between mice kept in the Specificpathogen-<br/>Free (SPF) and CV areas was observed and maybe responsible for<br/>the differences in the T2-MZP functions. Moreover, Gal-1 was confirmed to be<br/>expressed by B cells and T2-MZP isolated …
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Effects of different antiretroviral treatments on gut microbiota of hiv-infected patients
The human gut microbiota has a symbiotic relationship with the host and plays a crucial role in the maintenance of health. HIV infection has been associated with a disturbance in gut microbiota (dysbiosis). Increased bacterial translocation and alterations to gut microbiota composition have been …
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SEX-DEPENDENT GUT MICROBIOME DIFFERENCES IN A TRANSGENIC MOUSE MODEL OF AUTISM
… Disorder (ASD). Changes in the diversity of the gut flora, and co-occurring gastrointestinal pathologies, have been consistently noted in studies of individuals with ASD. A number of mechanisms exist through which sAPPα overexpression may exert an influence on the initial development of the gut …
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Elucidating the Role of Pattern Recognition Receptors in Understanding, Treating, and Targeting Cancer
… factors were greater predictors over genotype of gut flora composition. This study concluded with a clearer understanding of NLRP1. We next investigated the effectiveness of a novel tumor ablation therapy, termed High-Frequency Irreversible Electroporation (H-FIRE) in a murine model of triple …
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The Gut Microbiome as a Novel Approach for Reversing Long-Term Inflammation and Accelerated Aging Across the Lifespan
… One promising intervention is to manipulate the gut microbiome, which is instrumental in immune regulation. The aim of this dissertation is to assess how post-HIE changes in gut flora and systemic inflammation intersect with aging processes, and to evaluate if microbiome-directed therapies can …
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Determining fecal bacterial profiles of a human-habituated wild chimpanzee population in Mahale Mountains National Park, Tanzania
Intestinal flora of wild chimpanzee has not been studied. Fecal flora analyses currently give insight to this environment. We collected feces from twelve human-habituated wild chimpanzees in each of three age groups: four juveniles, four sub-adults, and four adults. We analyzed fecal samples using …