Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"Gut barrier"”.
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Influence of infant milk formula processing on protein digestion and gut barrier health in vitro and in vivo
… will be digested differently in the infant gut compared to native dairy proteins. The degree of glycation will also alter digestion. Employing lower temperatures or non-thermal processing methods, or both, should produce IMF with a higher native protein content and less advanced glycation …
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Integrity of the Barrier Epithelium in Drosophila Gut is Mediated by Factors That Regulate Intestinal Stem Cell Activity
… specific regulatory genes, and proposing gut barrier function–specific genes as regulators of commensal bacteria density. The results from this project have shown that intestinal stem cells (ISCs) respond systemically in the presence of autonomously induced, visceral muscle (VM)-localized …
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Molecular Determinants of TRP Channel Gating
… conditions, including hyperalgesia, gut barrier dysfunction, and ataxia. Thermal hyperalgesia is a condition in which previously innocuous stimuli become painful as a result of inflammatory responses. TRP Vanilloid member 1 (TRPV1) is a contributor to this process due to its …
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Exploring the gut microbiome: metaproteome analysis of HIV-exposed uninfected infants
… to disease and have weaker immune responses. The gut microbiome plays a pivotal role in human health by aiding in metabolism, nutrient availability and immune development and function. The mucosal immune system and microbiome work in synergy to maintain host immunity and balance for optimal host …
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INFLAMMATORY AND T-CELL HOMEOSTASIS PARAMETERS IN DUAL AND TRIPLE COMBINATION ANTIRETROVIRAL THERAPY (CART) FOR HIV INFECTION
… HIV reservoir, circulating Th1/Th2 cytokines, gut integrity, and microbial translocation in individuals with PHI and chronic HIV infection (CHI) before and after cART initiation; (2) assessing immune parameters, gut barrier dysfunction, and mitochondrial stress in PLWH switching from triple to …
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Development of in vitro infant intestinal models to assess responses to infant formulae
Early postnatal nutrition and intestinal barrier maturation are intimately linked, with the neonatal gut characterized by higher permeability than in adults. The aim of this thesis was to develop and validate in vitro models that mimic the infant intestinal barrier. Once developed, these models …
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Encapsulated butyric acid as a functional ingredient in canine health
… recognized to play a large role in maintaining gut immunity and gut barrier function, and it also contributes to broader systemic effects including metabolic regulation, anti-inflammatory activity, oxidative stress reduction, and epigenetic modulation (Guilloteau et al., 2010; Zhang et al., …
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A microphysiological system for studying barrier health of live tissues in real time
Epithelial cells create barriers that protect many different components in the body from their external environment. The gut in particular carries bacteria and other infectious agents. A healthy gut epithelial barrier prevents unwanted substances from accessing the underlying lamina propria while …
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Control of Turnip yellows virus: Assessing impact on oilseed rape quality traits and dissecting circulative transmission by aphids
… transcytosis of TuYV particles across the aphid gut barrier, PMRi was used to dissect its role in the circulative transmission process. This revealed that Rack1 may have a direct role in TuYV acquisition by GPA. This work further demonstrates the potential of PMRi as a postgenomics tool in aphids …
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Prebiotic supplementation with inulin and exercise influence gut microbiome composition and metabolic health
… lack of exercise, and detrimental changes to the gut microbiome. Dietary intake and exercise are modifiable lifestyle factors for reducing T2D risk; however, several questions remain unanswered related to the efficacy and role of prebiotics and exercise, and their respective influences on gut …
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Dietary Manipulation at Pre-Conception and During Development Influence Metabolism and Gut Microbiota in Rats
… modulated by a plethora of factors, including gut microbiota, early post-natal nutrition, parental diet and epigenetics. Objective. This dissertation examines how dietary manipulation during the early post-natal period and during pre-conception alters metabolic, microbial and epigenetic …
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Effects of Acute Alcohol Exposure on Post Burn Intestinal Immunity: Role of IL-23
… injury. Several lines of evidence suggest that gut pathogens and/or their products may play a role in the development of sepsis and multiple organ failure reported in burn and trauma patients. In line with this hypothesis, our laboratory has demonstrated increased intestinal tissue damage, …
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Inulin Supplementation to Support Periodontal Health
… disease can also induce dysbiosis in the gut microbiota and contribute to low-grade inflammation. Prebiotic fibres, such as inulin, can selectively alter the intestinal microbiota and support homeostasis by improving gut barrier function, preventing systemic inflammation which may help …
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Citrobacter rodentium induced liver changes in C57BL/6 mice : animal model of acute inflammatory stress and injury
… rather, they appear driven more by proposed gut barrier compromise. In conclusion, gastrointestinal infection with C. rodentium alters systemic and hepatocytes specific responses, not previously appreciated from this enteric pathogen, making it a useful model for studying host-pathogen …
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Colonic metabolism of dietary grape seed extract: Analytical method development, effect on tight-junction proteins, tissue accumulation, and pan-colonic pharmacokinetics
… grape seed extract increased the expression of gut junction protein occludin and reduced levels of fecal calprotectin, which suggests an improvement of gut barrier integrity and a potential modulation of endotoxemia. Additionally, chronic supplementation of the diet with flavanols did not …
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Characterising dysbiosis in Alzheimer’s disease utilising the APP/PS1 mouse model
The gut brain axis (GBA) is a bi-directional communication system between the gastrointestinal tract (GI) and the brain. Correct functioning of the GBA is essential to human health and its dysfunction has been widely implicated in a variety of diseases including, irritable bowel syndrome (IBS), …
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Exploring glucagon-like peptide 1-secreting L-cells as signal transducers in the microbiota-gut-brain signalling pathways
Background: Communication across the microbiota-gut-brain axis is integral to homeostatic functions throughout the body. However, the mechanisms behind this communication network have yet to be fully elucidated. There is mounting evidence that bacterially secreted metabolites, such as short-chain …
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Understanding the role of phages in the mammalian gut microbiome
A healthy gut microbiome supports a stable microbial community that regulates immune responses, defends against pathogens, maintains gut barrier integrity, and modulates metabolic processes. Disruptions of the balanced microbial community, followed by effects on host health, often called dysbiosis, …
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Effects of diet and loss of ovarian hormone production on adiposity, inflammation, cecal integrity, and gut microbial communities of rodent models
… the gastrointestinal (GI) microbiota, disrupted gut barrier function, and inflammation, but little is known regarding the involvement of the GI tract in obesity associated with loss of ovarian hormone production. Herein, we hypothesized that GI tract and the gut microbiota are involved in the …
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Unravelling the impact of pesticides on the microbiota-gut-brain axis
The gut microbiota exists within a dynamic ecosystem influenced by various factors, including exposure to xenobiotics such as pesticides. There is an increasing emphasis on the role of the gut microbiota in maintaining host health, including growing evidence for its role in regulating brain …
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