Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 54 for “"Gut bacteria"”.
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Complex glycan utilization preferences of human gut bacteria
… In order to investigate how the members of our gut microbiota utilize glycans and activate their respective polysaccharide utilization loci (PULs), we performed a series of time-course assays in which two model organisms, Bacteroides thetaiotamicron (Bt) and B. ovatus (Bo), were individually …
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Interactions between salmonella typhimurium and human gut bacteria
… study the interaction between Salmonella and the gut bacteria to elucidate the elements that influence the ability of the pathogen to overcome the colonisation barrier mediated by the gut microbiota and why Salmonella can persist in ‘healthy’ individuals in a carrier state after infection. In this …
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Interactions of Environmental Pollutants with Human Gut Bacteria
… been shown to have a strong impact on the human gut microbiota both in vitro and in vivo, relatively little is known about the effects of other compounds, such as pesticides, processing contaminants and environmental pollutants. To systematically assess the impact of chemical pollutants on gut …
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Characterising antibiotic susceptibility and resistance in human commensal gut bacteria
… susceptibility and resistance in human commensal gut bacteria The human commensal gut microbiota can act as a reservoir of antimicrobial resistance genes that can persist and spread to pathogens. However, the extent and diversity of antibiotic resistance encoded by human commensal bacteria remains …
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Relationships between invertebrate detritivores and gut bacteria in marine systems
… greatest at burrow linings. The mode of feeding, gut structure and diet of the two prawn species differ, although gut throughput rates are similar (ca. 6h). U. africana is a filter feeder which non-selectively ingests small particles which are further sorted in the modified filtertype gastric mill …
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Evaluating substrate utilisation to target newly identified health-promoting gut bacteria
… and/or activity of potentially beneficial human gut microorganisms through the provision of specific substrates has been the subject of many studies over recent decades. Such substrates can include prebiotics, which promote growth in a targeted manner, but prebiotics can also be combined with …
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Evaluation of ligninolytic enzymes of (coptotermes curvignathus) gut bacteria for oil palm residues biodelignification
… lignin degrading enzymes secreted by the termite gut bacteria, and also to explore the green delignification of oil palm residues for sustainable pulping. The lignin degrading bacteria (LDB) from the termite gut were isolated and the lignin degrading enzymes (LDE) from the LDB cultures in kraft …
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The role of mucus in the cross talk between gut bacteria and the host
… lymphocytes (IELs) respond to the invading bacteria that circumvent the mucus barrier. In this study two approaches were used to investigate the role of mucus in intestinal homeostasis; firstly the impact of γδ IELs on the mucus layer, and secondly the adhesion properties of the gut symbiont …
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RELATIONSHIPS BETWEEN DIETARY FIBER STRUCTURAL FEATURES AND GROWTH AND UTILIZATION PATTERNS OF HUMAN GUT BACTERIA
… is considered an essential strategy to influence gut microbiota, which is associated with many diet-related chronic diseases such as obesity, diabetes, and inflammatory bowel diseases. In order to make a better choice of dietary fiber for a desired microbiota shift related to a health outcome, …
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To Investigate The Impact Of Gut Bacteria On Efflux Transporter Expression And Function In Gastrointestinal Mucosae
Gut microbiome diversity may alter oral bioavailability and contribute to individual variations in drug therapy. Therefore, understanding molecular links between the gut microbiome and oral drug disposition is critical for realizing the goals of precision medicine. The purpose of the study was to …
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Culture-independent identification of gut bacteria in fourth-instar red imported fire ant, Solenopsis invicta Buren, larvae
… of investigations of obligate endosymbiotic bacteria possibly involved in nutrient distributions. I attempted to first identify what bacteria species are in the guts of larvae followed by antibiotic and microscopy work to further study their roles in the ants. The composition of the bacterial …
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Identification of bacteria-regulated mechanisms for the pathogenesis of inflammatory bowel diseases (IBD) and development of upconverting nanoparticle (UCNP) luminescence imaging for the monitoring of gut bacteria
… ulcerative colitis (UC). The environment, the gut microbiota, the genetic make-up and the immune response are believed to contribute to the aetiology of the disease. Non-steroidal anti-inflammatory drugs (NSAIDs) are believed to exacerbate inflammation in patients with IBD. However, the …
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The gut microbiome of the western lowland gorilla (Gorilla gorilla gorilla): implications for overall ecology
… of primate ecology and evolution. Nonetheless, gut bacteria, which play central roles in the physiological adaptability of mammals, have been usually overlooked in primate studies. Here, I use a combination of high throughput molecular approaches to study the compositional and functional …
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Probiotics for the management of kidney stone disease
… tract and excreted in urine or degraded by gut bacteria. Oxalate-degrading gut bacteria play a critical role in human oxalate homeostasis, evidenced by increased research interest in them as potential probiotics in the management of kidney stone disease. In South Africa, kidney stones are …
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High-Throughput Discovery of Stimuli of Bacterial Two-Component Systems from the Human Gut Microbiome
The human gut microbiota is a dense and diverse community of bacteria that interact with the host and have major impacts on health and disease. Two-component systems (TCS) are the primary means by which bacteria, including those in the gut microbiome, sense and adapt to their environment. The …
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Integrative Analysis of the Human Gut Phageome Using a Metagenomics Approach
Bacteriophages (or phages; viruses that infect bacteria and archaea) profoundly influence microbial communities. Given the impact of the gut microbiome composition and function on human health, there is a growing focus on phages that inhabit the gut ecosystem. However, the extent of viral …
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Gut Microbiome Dysbiosis Exacerbates Malaria Severity in Ugandan Children
… fully known, but murine studies implicate the gut microbiome. It remains unknown if gut microbiota contributes to SM pathogenesis in children. To address this knowledge gap, we sequenced the gut bacteria populations in stool samples from Ugandan children <5 years-old with SM and community …
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Immune Checkpoint Blockade Induces Gut Microbiota Translocation That Augments Extraintestinal Anti-Tumor Immunity
Gut microbiota are critical for effective immune checkpoint blockade therapy (ICT) for cancer. The mechanisms by which gut microbiota augment extraintestinal anti-cancer immune responses, however, are largely unknown. Here, we find that ICT induces the translocation of specific endogenous gut …
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The evolution and genetics of vector competence in mosquito disease vectors
… in future disease control programmes. Mosquito gut bacteria affect the development of parasites ingested by mosquitoes. As different bacterial species have different effects, dissimilarities in gut composition could be an important cause of variation in vector populations. The first study …
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Microbial glucosinolate metabolism: Characterization of Enterococcus faecalis XL1 and functional analysis of a GH4 enzyme
… plant myrosinases are inactivated by cooking, gut microbes become the primary contributors to ITC formation. However, the microbial enzymes and pathways responsible for GSL metabolism remain poorly understood. This dissertation investigates the bacterial mechanisms underlying GSL hydrolysis, …
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