Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 1947 for “"Gut"”.
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Gut-brain axis: Central impact of gut peptides and metabolic drug on monoamine neurotransmission
… on dopamine receptor function. In succinct, gut peptides impact on neurotransmission as well as behavioural activities and potentially modulate psychostimulant effects.
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Gut failure: Diagnosis and management
Background: Inadequate gut function (IGF) or intestinal failure (IF) is common, particularly in surgical patients and the critically ill. It is difficult to measure objectively, and as a consequence its effects on outcome are contentious and treatment options are limited. Because of the gut's …
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The gut microbiota in depression
The accruing data linking the gut microbiota to the development and function of the central nervous system has been proposed as a paradigm shift in neuroscience. Neuroimmune, neuroendocrine and neural communication pathways exist between host and microbe. These pathways are components of the …
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Gut microbes and brain function
The gut-brain-microbiota axis comprises an extensive communication network between the brain, the gut, and the microbiota residing there. If the composition or the diversity of the gut microbiota is impaired, this can have negative consequences for host health and has been associated with disorders …
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Towards engineering the gut microbiota
… organisms in successional states in the human gut, and identify host- and diet-derived metabolites as environmental signals mediating the growth and colonization of these organisms. In the second study, I examined the potential for using targeted manipulations of diet to favor selective growth …
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Multifunctional Wireless Gut-Brain Neurotechnology
… chips for organs as diverse as the brain and the gut were developed. This approach produces meters-long continuous fibers that can integrate light sources, electrodes, thermal sensors, and microfluidic channels in a miniature footprint. Paired with custom-fabricated control module, the fibers …
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Examining the gut microbiota in aging
The human gut microbiome, comprised primarily of bacteria, plays a crucial role in overall health and physiology by regulating metabolism, immunity, and behavior through the microbiota-gut-brain axis (MGBA). Key functions include fermenting complex carbohydrates into short-chain fatty acids (SCFAs) …
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Antibiotic resistance in the gut microbiota
… understanding the effects of antibiotics on the gut microbiota, as well as the potential for such populations to act as a reservoir for resistance genes, is imperative. This thesis set out to investigate the gut microbiota of antibiotic treated infants compared to untreated controls using …
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Cystic fibrosis and the gut microbiota
The role of the gut microbiota in host health has been established in recent years and has been shown to be altered in numerous disease states, including Cystic Fibrosis (CF) cohorts. This thesis investigates the gut microbiota and microbiome in CF persons and how it may be manipulated through …
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CNS Remyelination and the Gut Microbiota
Remyelination describes the regeneration of myelin sheaths, and is considered one of the most promising strategies for improving the prognosis of demyelinating diseases such as multiple sclerosis. Data from animal models and human studies have shown that remyelination can occur extensively in the …
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Gut-brain interactions in food reward
Food choice and preference have been linked to post-ingestive consequences of food consumption. Many ultra-processed foods deliver calories rapidly and are highly rewarding. In literature surrounding substances of abuse, the speed at which a drug reaches the brain affects its abuse potential; this …
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Gut Microbiota Regulation of SLE Pathogenesis
… the intricate connection between SLE and the gut microbiota. A literature review offered a comprehensive analysis of current research, with a particular emphasis on potential interactions between bacterial flagellin and Toll-Like Receptor 5 (TLR5) on immune cells. These interactions garnered …
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Understanding the development of gut microbiota and effect of Salmonella Typhimurium infection on gut microbiota in layers
In the last two decades, the focus on chicken gut microbiota has increased exponentially due to its critical role in digestion, nutrient absorption, modulation of immunity, and protection against enteric pathogens. Thus, understanding its role in food-producing animals like chickens is essential …
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Development of novel therapies for gut dysbioses
This thesis reports results of 30 years of systematic clinical investigations carried out by the author in the general area of “infection-driven inflammation”. The Centre for Digestive Diseases (CDD) endoscopy clinic was founded by the author in 1984 closely coinciding with Drs Barry Marshall and …
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Metagenomic Analyses of the Human Gut Virome
<p>The human gut harbors tens of trillions of microbes belonging to all three domains of life, Bacteria, Archaea, and Eukarya; most are members of Bacteria. These organisms collaborate and compete for functional niches and physical space: habitats), together forming a continuously functioning …
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Gut Microbiota of Migratory Passerines at Stopover
<p>Although the gut microbiota provides many beneficial functions to animal hosts, relatively little is known about the gut microbiota of passerines. It is likely that gut microbes are especially important during the migratory phase; however gut atrophy experienced during prolonged migratory flight …
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Engineering the gut microbiome of honey bees
… use. These bees house a simple, conserved gut microbiome that is important for their health. Can we use this gut microbiome to protect bees in new ways? Synthetic biology combines recombinant DNA technology and rational design principles to redesign biological processes. Microbiome …
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Host-microbe interactions in the inflamed gut
… 10415 (NCIMB) is capable of reducing chronic gut inflammation by changing the existing gut microbiota composition and aimed to identify mechanisms that are involved in possible beneficial effects of the probiotic. To identify health-promoting mechanisms of the strain, we used interleukin …
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The gut microbiota in immune-mediated disorders
The human gut microbiota is a diverse community of microbes residing in the intestine. Evidence from various animal models and human studies have highlighted its potential role in health, metabolic and immune-associated conditions such as osteoporosis, inflammatory arthritis, inflammatory bowel …
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