Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Guillain-Barré syndrome"”.
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A resonant mirror biosensor approach to understand antibody-antigen interactions in Guillain Barré Syndrome
Guillain Barré Syndrome in humans is characterised by ascending paralysis. It is often associated with preceding infections two to four weeks prior to nadir and is fatal in five percent of cases. Antibodies specific to several nerve components are frequently associated with clinical symptoms in …
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Intramuscular immunization of mice with KatA (catalase) generates functional antibodies against Campylobacter jejuni invasion of gut epithelial cells in vitro
… recent association of C. jejuni infections and Guillain-Barré syndrome has heightened the need to develop effective anti-Campylobacter vaccines. Due to the risk of auto-immunity, vaccination using inactivated whole-cells or attenuated cells cannot be considered. Subunit vaccines however are a …
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Generation and analysis of transgenic mice expressing ovalbumin as a neo-self antigen under control of the myelin basic protein promoter
… system disorders of Multiple Sclerosis and Guillain Barré Syndrome. Previous experimental autoimmune encephalomyelitis (EAE) and experimental autoimmune neuritis (EAN) models have demonstrated that T cells play a major role in these diseases. Which roles CD4 and CD8 T cells specifically have …
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Guillain Barre Syndrome (GBS) in Cape Town, South Africa: a descriptive outcomes cohort study
INTRODUCTION Guillain-Barré syndrome (GBS) or acute inflammatory demyelinating polyradiculoneuropathy (AIDP) is an important cause of acute severe and life-threatening weakness. It occurs worldwide and may affect all age groups, but varies widely in clinical presentation, subtype, …
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A microbiological and molecular study of campylobacter and related species isolated from ostriches (Struthio camelus)
… able to cause gastroenteritis, bacteraemia, the Guillain-Barré syndrome, reactive arthritis and other diseases in humans. While poultry, cattle and sheep are known reservoirs for campylobacter, very little is known about ostriches as a vector for these organisms. What is known, however, is that …
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Functional analysis of glycosylation of Zika virus envelope and NS1 proteins
… causes devastating congenital abnormities and Guillain-Barré syndrome. ZIKV has two important glycoproteins, both the envelope (E) protein, and nonstructural protein 1 (NS1). The ZIKV envelope (E) protein is responsible for viral entry and represents a major determinant for viral pathogenesis. …
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Functional analysis of glycosylation of Zika virus envelope and NS1 proteins
… causes devastating congenital abnormities and Guillain-Barré syndrome. ZIKV has two important glycoproteins, both the envelope (E) protein, and nonstructural protein 1 (NS1). The ZIKV envelope (E) protein is responsible for viral entry and represents a major determinant for viral pathogenesis. …
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The role of biofilms in Campylobacter jejuni survival in the food chain
… to severe post infection complications, such as Guillain–Barré syndrome. Despite the fastidious nature of C. jejuni, it is able to survive food chain transit. One survival mechanism proposed to aid in C. jejuni food chain survival is its formation of, or incorporation into, biofilms. Biofilms are …
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An Examination of the Safety and Efficacy of Aripo-Zika as a Zika Virus Vaccine Candidate
… RNA virus, and its disease has been linked to Guillain Barré Syndrome (i.e., a debilitating autoimmune disorder that affects the nerves) in adults and congenital birth defects including microcephaly (i.e., a neurodevelopmental disorder due to impaired neural cell proliferation) in newborns. …
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Forced-Exercise Dependent Changes in Cellular Immunity: Effects on Experimental Autoimmune Neuritis
<p>Guillain-Barré Syndrome (GBS) is a debilitating inflammatory autoimmune disease of the peripheral nervous system that is characterized by rapid-onset paraparesis with areflexia progressing to neuromuscular paralysis. The most common form of GBS observed in North America and Europe is acute …
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Mechanistic analysis of the Zika virus translation-replication switch
… linked to congenital microcephaly as well as Guillain-Barré syndrome in infected adults. During infection, flavivirus replication is known to require genome circularisation, mediated by long-range RNA- RNA interactions between cis-acting elements at the 5′ and 3′ ends of the genome. This …
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Quantitative Microbial Risk Assessment Model to Estimate Exposure to Campylobacter from Consumption of Chicken in the United States
… deaths: 37, cases of Campylobacter-associated Guillain-Barré Syndrome (GBS): 1,373, and cases of Campylobacter-associated Irritable Bowel Syndrome (IBS): 9,501. The associated annual economic burdens were ~$192 million for acute campylobacteriosis, ~$77 million for GBS, and ~$96 million for …
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Statin-Mediated Attenuation of Chemokine Expression in Peripheral Nerve Vascular Endothelial Cells
… play a pivotal role in the pathogenesis of Guillain-Barré Syndrome (GBS), a debilitating autoimmune disorder that affects the peripheral nervous system. By up-regulating endothelial expression of chemokines and cell adhesion molecules (CAMs), TNF-α facilitates the recruitment and trafficking …
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Synthetic studies toward 6-deoxy-ß-D-ido-heptopyranosides related to capsular polysaccharides of Campylobacter jejuni
… is also associated with the development of Guillain-Barré Syndrome, an autoimmune condition that results from the development of antibodies elicited against the bacterial lipopolysaccharides that can cross-react with human gangliosides present on nerve tissue, resulting in neurological …
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Identification and characterization of virulence associated factors of C. jejuni
… as a post-infection complication, in rare cases Guillain-Barré syndrome might emerge. In contrast, C. jejuni is only a commensal in poultry, where the pathogen predominantly resides in the cecum which contains many anaerobic fermentative bacteria. Within these natural habitats, C. jejuni is able …
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Anti-GD1a antibody targeted disruption of the node of Ranvier in a mouse model of acute motor axonal neuropathy
Guillain-Barré syndrome (GBS) is a peripheral neuropathy characterised by acute flaccid paralysis. The axonal variant is associated with anti-GD1a ganglioside antibody-dependent, complement-mediated injury to the peripheral axon with conduction block. The blood-nerve barrier (BNB) relatively …
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Comparative analysis of African and Asian/American Zika virus strains at the transcriptional and translational level
… with neurological complications such as Guillain-Barré syndrome in adults and congenital ZIKV syndrome (e.g., microcephaly) in newborns. Currently, it is not understood why this newly emerged Asian/American ZIKV results in a more severe disease than the African ZIKV. This project focused …
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Die funktionelle Relevanz humoraler und zellulärer Immunreaktionen gegen Campylobacter jejuni in der Pathogenese von Immunneuropathien
… auch C. jejuni-Stämme eingesetzt, welche von Guillain-Barré- (GBS) und Miller-Fisher-syndrome (MFS) Patienten isoliert worden waren. Es wurden Ultraschall-Gesamt-Homogenate der C. jejuni Stämme sowie von Salmonella typhimurium als Kontrollbakterium hergestellt. Anschließend wurden verschiedene …
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Retrospektive Untersuchung über psychische und körperliche Langzeitbeeinträchtigungen bei Patienten nach Guillain-Barré-Syndrom
… bei Patienten nach schwerem Guillain-Barré-Syndrom erheben und zu beschreiben wurden 1994 41 Patienten in der Neurologischen Universitätsklinik Würzburg nachuntersucht. 1 bis 12 Jahre nach der akuten Erkrankung wurden die Patienten mittels eines halbstrukturierten Interviews …
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Aspects of the Immunobiology of Myelin Oligodendrocyte Glycoprotein (MOG)-induced Experimental Autoimmune Encephalomyelitis (EAE)
… affecting the peripheral nervous system such as Guillain Barré syndrome (GBS). In GBS a pathogenic antibody response to gangliosides appears to be triggered by infections with particular serotypes of Campylobacter jejuni (Fredman, 1998; Willison and O´Hanlon, 1999). In the majority of patients …