Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 40 for “"Guidance Cues"”.
-
Vibrotactile Guidance Cues For Target Identification
… dissertation was to establish how vibrotactile guidance cues can be used to improve marksmanship. This work originated in an effort to provide covert communication, navigation, and weapon aiming cues for infantrymen. It is predominantly an application-driven investigation rather than driven a …
-
Neuronal growth cone responses to extracellular guidance cues : an in vitro study
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1998.
-
Regulation of the actin cytoskeleton in the neuronal growth cone
… the detection of diffusible and surface-bound guidance cues. The growth cone, a specialized structure found at the tips of axons and dendrites, detects and interprets these cues. Activation of downstream intracellular singling pathways leads to changes in the cytoskeleton of the growth cone …
-
Characterizing New Molecules and Mechanisms of Semaphorin/Plexin/MICAL Signaling
… behaviors are regulated through the ability of guidance cues that are present outside of cells to exert precise effects on the cell’s internal actin cytoskeleton. To help characterize an underlying logic for these cellular changes and proper cellular function I have been characterizing how one …
-
The Intracellular Domain of the Frazzled/Dcc Receptor is a Transcription Factor Required for Commissural Axon Guidance
… conserved families of attractive and repulsive cues steer axons by signaling through receptors that are expressed on axonal growth cones. In the canonical model of axon guidance receptor signaling, ligand binding induces the formation of protein complexes on receptor cytoplasmic domains, which …
-
Investigating the Role of MicroRNAs in Regeneration and Axonal Pathfinding
… the growth cone, which senses and interprets guidance cues in its surrounding environment to change the direction of axonal outgrowth. MicroRNAs, which regulate mRNA translation, have recently been shown to regulate both neurite outgrowth and growth cone guidance in response to classical …
-
Topological organization of the trigeminal system in the lamprey and restoration following axonal regeneration
… lampreys suggests the possible involvement of guidance cues. For example, previous studies in fish with optic nerve lesions have shown the involvement of EphA/ephrin-A in the guidance of regenerating retinal axons and the restoration of a topological organization of the retinotectal system. For …
-
Guidance of Developing Motor Neurons into the Periphery
… and then progresses to increasingly specific guidance signaling systems. MN subtypes are classified by the combined activities of transcription factors and molecular signaling systems that determine axon trajectory. Molecular cues have been attributed to the organization of MNs into columns …
-
Development and application of optical microscopy tools for the study of axon guidance
… of axons relies on the presence of chemical cues sensed through guidance cue receptors. Upon receptor activation, intracellular signalling pathways are initiated, one of which induces local protein synthesis (LPS), a key process to enable rapid navigational responses to guidance cues. …
-
Neuronal Polarization and Axonal mRNA Localization on Microfabricated Substrates
… Various arrangements of numerous growth factors, guidance cues, and other molecules influence both the interconnectivity of neurons and the subcellular makeup of individual neurons. This dissertation describes experiments that used an engineering-based approach to study the mechanisms that …
-
Repulsive axonal pathfinding requires the Ena/VASP family of actin regulatory proteins in vertebrates
… interpretation of many attractive and repulsive guidance molecules. For the incredibly complicated wiring diagram comprising the vertebrate nervous system to elaborate properly, the highly motile "growth cone" at the tip of an axon must sense extracellular embryonic cues and respond through a …
-
Substrate stiffness tunes the neuronal response to the chemical guidance cue semaphorin3A
… how growth cones sense and respond to chemical guidance cues. However, the nervous system presents a rich and varied mechanical environment, and neuronal growth cones also respond strongly to physical stimuli. Previous work from the Franze research group identified that tissue stiffness and the …
-
Sema-1a Reverse Signaling Promotes Midline Crossing In Response To Secreted Semaphorins
… majority of axons, an essential step in proper guidance involves crossing the midline, and failure to do so often results in an inability to coordinate movement. Attraction to the midline depends in part on the highly conserved guidance receptor DCC, or Frazzled in Drosophila, which signals …
-
The role of Ena/VASP and associated proteins in regulation of neuronal morphology and filopodia architecture
… connect to numerous synaptic targets. While many guidance cues and their receptors have well-characterized roles in cortical axon guidance, the pathways that link these signals to cytoskeletal remodeling remain poorly understood. The Ena/VASP family of proteins function as key signaling molecules …
-
Developmental Dynamics of the Mouse Retinocollicular Projection: A Quantitative Characterisation
… influenced by both molecular and activity-based cues. The interaction between these different cues, however, is unclear: conventionally molecular guidance cues set the basic topography, which is then refined by activity-based mechanisms. A number of computational models have investigated this …
-
An investigation into novel molecules involved in the development of the nervous system of Drosophila melanogaster
… or muscles. This process, referred to as “axon guidance,” relies upon receptors on axons detecting secreted or membrane-associated guidance cues within the developing organism, which attract or repel axons. While many cues and receptors have been identified over the last few decades, many within …
-
Aberrant assembly and function of a hippocampal circuit in a genetic mouse model of schizophrenia
… target pCREB. Finally, Nrp1 and Sema3A, guidance cues that are regulated by cAMP, are altered in the Disc1Tm1Kara mutant mice. Overall, this mouse is a valuable model of a known genetic variant of schizophrenia susceptibility and adds to our understanding of the pathology of the disease. …
-
Retinoic Acid and the Underlying Cellular Mechanisms involved in Neurite Outgrowth and Growth Cone Turning during Regeneration
… role of RA in neurite outgrowth and growth cone guidance. Recently however, a novel phenomenon has been identified, in which neurite outgrowth occurs from cut nerves of Lymnaea CNS “floating” on the surface of cultured medium. In this study, I examined whether RA could induce or guide neurite …
-
Investigations of collective cell movement during gastrulation in the chick embryo
… in serum would help to validate the role of guidance cues in vivo and elucidate a fundamental developmental process.
-
Repulsive cues and signalling cascades of the axon growth cone
… the nature and mechanisms of action of repellent cues for growing axons. In particular I try to resolve the controversy in the literature regarding the need for protein synthesis in the growth cone in response to external guidance cues. My results resolve the conflicting data in the literature on …
Page 1 of 2