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Showing 1 to 17 of 17 for “"Guanylyl Cyclase"”.
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Structure and dynamics of soluble guanylyl cyclase
Soluble guanylyl cyclase (sGC) is one of the key enzymes involved in many fundamental biological processes including vasodilatation. It can be allosterically activated by synthetic compound such as YC-l. Recently, the 3D structure of adenylyl cyclase (AC), which is a homologue of sGC, was …
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Regulation of the nitric oxide receptor, soluble guanylyl cyclase
Soluble guanylyl cyclase (sGC) is the best established receptor for nitric oxide (NO) and regulates a great number of important physiological functions. Surprisingly, despite the wellappreciated roles of this enzyme in regulation of vascular tone, smooth muscle cell proliferation, platelet …
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No-Independent Modulation of Soluble Guanylyl Cyclase (Sgc) Activity and Function
<p>Soluble guanylyl cyclase (sGC) plays a key role in the nitric oxide (NO) signaling pathway, where it functions as an NO receptor and generator of a secondary intracellular messenger, cGMP. In addition to NO, investigators have identified a number of proteins that interact with sGC and modulate …
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Regulation of natriuretic peptide system activation:effects of spontaneous natriuretic peptide mutations and identification of novel natriuretic peptide receptor phosphorylation sites.
Guanylyl cyclase A and B (GC-A and GC-B) are transmembrane guanylyl cyclase receptors that mediate the physiologic effects of natriuretic peptides, including reduction of blood pressure and blood volume, stimulation of long bone growth, and regulation of cardiac size. Atrial natriuretic peptide …
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Acute and chronic effects of nitric oxide on cardiomyocyte guanylyl cyclase : implications for the modulation of the heart following environmental, physiological and clinical exposure to nitric oxide
The nitric oxide (NO) - guanylyl cyclase (GC) - guanosine 3' ,5'-cyclic monophosphate (cGMP) signal transduction pathway has been shown to play a role in the modulation of ventricular contractility by the parasympathetic nervous system. Environmental/occupational NO exposures, the gastric …
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Influence of the Atrial Natriuretic Peptide on TNF- αα α -activated human endothelial cells
… inhibit the activation of NF- B via binding its guanylyl-cyclase-coupled NPR-A and -B receptor. We could further elucidate the molecular mechanism leading to the inhibition of NF- B activation by ANP. ANP was shown to transcriptionally activate the expression of I B isoforms. In consequence of …
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Repulsive cues and signalling cascades of the axon growth cone
… concentration-independent and does not involve guanylyl cyclase, but it does share a dependence upon mTOR activity and the synthesis of RhoA, sufficient to cause collapse downstream of Semaphorin-3A. The other axon-repelling domain of Nogo-A, Nogo-66, is partially dependent upon the proteasome …
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MOLECULAR APPROACHES TO ANALYZE HORIZONTAL RESISTANCE AMONG PLANT SPECIES (MAIZE, SOYBEAN, AND ARABIDOPSIS) TO SYNTENIC FUSARIAL PATHOGENS (F. GRAMINEARUM AND F. VIRGULIFORME)
… etc. First, a maize gene that encoded a putative guanylyl cyclase-like protein (ZmGC1; EC 4.6.1.2) was characterized and shown to be associated with resistance to Gibberella ear rot caused by F. graminearum. The putative ZmGC1 amino acid sequence was 53% identical and 65% similar to AtGC1, one of …
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Intimations on the Development of Effective Treatment for the Prevention of Preterm Birth: β3 Adrenergic Receptor Signaling in the Human Myometrium
… to mediate relaxation via nitric oxide (NO)-guanylyl cyclase-cGMP signaling. However, NO-mediated relaxation of the myometrium is cGMP-independent. Our studies showed that β3AR agonist, mirabegron, can be used to mediate relaxation in the human myometrium. The mechanisms associated with this …
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Interazione dopamina-ossitocina nel controllo centrale della risposta erettile
… dopaminergic cell bodies, NO synthase and guanylyl cyclase into the VTA. The results obtained suggest the existence of a neural circuit where dopaminergic and oxytocinergic neurons play a key role in the motivational/rewarding and consummatory aspects of male sexual behavior. When …
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OXIDATIVE STRESS AND THE GUANOSINE NUCLEOTIDE TRIPHOSPHATE POOL: IMPLICATIONS FOR A BIOMARKER AND MECHANISM OF IMPAIRED CELL FUNCTION
… evidence of oxo8GTP as an inhibitor of soluble guanylyl cyclase (sGC). A significant induction of oxo8GTP in cell-free preparations as well as in PC12 and HEK 293T cells exposed to physiologically relevant oxidative conditions generated with 10 ?M copper sulphate and 1mM L-Ascorbic Acid (Cu/Asc) …
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OXIDATIVE STRESS AND THE GUANOSINE NUCLEOTIDE TRIPHOSPHATE POOL: IMPLICATIONS FOR A BIOMARKER AND MECHANISM OF IMPAIRED CELL FUNCTION
… evidence of oxo8GTP as an inhibitor of soluble guanylyl cyclase (sGC). A significant induction of oxo8GTP in cell-free preparations as well as in PC12 and HEK 293T cells exposed to physiologically relevant oxidative conditions generated with 10 ?M copper sulphate and 1mM L-Ascorbic Acid (Cu/Asc) …
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Characterisation of Guanylin and Uroguanylin in the Digestive System
… lumen. Those active peptides activate the guanylyl cyclase C (GC-C) receptor from the lumen and catalyse the production of the intracellular secondary messenger cGMP. Subsequently cGMP stimulates both cGMP- dependent protein kinase II (PKGII) and protein kinase A (PKA). Both PKGII and PKA …
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THE IDENTIFICATION OF NOVEL INORGANIC CARBON SENSITIVE ENZYMES
Adenylyl cyclase catalyses the formation of the second messenger adenosine-3’, 5’-monophosphate from adenosine triphosphate, and is involved in a number of diverse signalling pathways in eukaryotes and prokaryotes. Adenylyl cyclases are diverse in their structure and biochemistry, and have been …
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MOLECULAR AND FUNCTIONAL CHARACTERISATION OF THE ROLE OF HYDROGEN SULPHIDE IN SEXUAL MEDICINE
… of both the active and inactive forms of soluble guanylyl cyclase (sGC) ß1 and stimulating the translocation of sGCa1 from the cytosol to the membrane. Overall, H2S seems to play a `supportive¿ role with respect to NO pathway in erectile physiology, amplifying NO signalling through dual action of …
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Spectroscopic investigation of phytochromes and NIR fluorescent variants
… In the studies on the phytochrome-activated di-guanylyl cyclase IsPadC, the IR spectra suggest a reduced structural change of the PHY domain, which is essential for the formation of the activated (Pfr) state. These results confirm a Meta/Pfr heterodimer model, which was developed on the basis of …