Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Guanylate-cyclase"”.
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Spring Forward or Fall Back? Redox State as a Determinant in Glutamate Signaling Pathways Adjusting Our Brain Clock
… as ryanodine receptor (RyR) and soluble guanylate cyclase (sGC), in the early night and late night, respectively. However, the determinant of this signaling-pathway bifurcation remains unknown. I tested the hypothesis that cellular redox state functions as this determinant. I found that …
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Interaction between RSNO and H2S: The formation, stability, and NO-donating capacity of SSNO- and the effect of SSNO- on platelet activation
… form several intermediates including the soluble guanylate cyclase (sGC) activating nitrosopersulfide (SSNO-). However, the stability and reactivity of this intermediate remained under debate, and hence, the relevance of nitric oxide (NO) and HS- reactions had not been established. With novel and …
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Biphasic neurogenic vasodilatation in the bovine intraocular long posterior ciliary artery
… inhibitor, L-NAME, and the inhibitor of soluble guanylate cyclase, ODQ, confirmed the involvement of NO from nitrergic nerves. Experiments involving treatment with capsaicin and the CGRP antagonist, CGRP8-37, failed to produce any evidence of involvement of CGRP in the second component of …
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Modulation of calcium signalling in human sperm by nitric oxide
… stored Ca\(^{2+}\) by a mechanism not requiring guanylate cyclase activation but mimicked by S-nitrosoglutathione (GSNO; an S-nitrosylating agent). Dithiothreitol application, to reduce protein –SNO groups, rapidly reversed the actions of NO and GSNO on [Ca\(^{2+}\)]\(_i\). The effects of NO, …
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EFFECTS OF DRUGS ON EXTRACELLULAR ARGININE LEVEL IN THE CEREBELLUM OF RAT
… fast-acting transmitter molecules and soluble guanylate cyclase. However, it does not seem to follow the strict mechanisms of traditional neurotransmitters in that its action does not require storage vesicles and specific receptors. As such, it is imperative to determine the conditions required …
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Plant natriuretic peptides - elucidation of the mechanisms of action
… ligand-binding domain and an intracellular guanylate cyclase (GC)/kinase domain and signal through the activity of their GC domain that is capable of generating intracellular cGMP from GTP. The structural resemblance of AtWAKL10 to vertebrate NP receptors could suggest a functional homology …
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Role of Protein Kinase G in Regulating Vascular Tone in Hypoxic Ovine Cerebral Arteries
… the discovery in 1977 of the influence of NO on guanylate cyclase, and the subsequent elucidation of the NO pathway, the role of cyclic guanidine monophosphate (cGMP)-dependent protein kinase (PKG) has been shown to be the main mediator of NO-induced vasorelaxation. Less well understood is the …
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An investigation into the synaptic conditions and celluar mechanisms underlying cerebellar synaptic plasticity
… an inhibitor of nitric oxide synthase (NOS), guanylate cyclase (GC), protein kinase G (PKG) or the GABAB receptor antagonist CGP62349 was included into the perfusion medium. Application of a nitric oxide (NO) donor, a cyclic guanosine monophosphate (cGMP) analogue or a phosphodiesterase (PDE) …
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Modulation of innate immunity by the cGMP signalling pathway in the drosophila malpighian tubule
… with one of its upstream components, soluble guanylate cyclase (sGC), the main intracellular target for NO (Marletta and Spiering 2003). Therefore, the aim of this study was to determine the potential role of the cGMP signalling pathway on regulation of the Drosophila Imd immune pathway. To do …
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Characterisation of Guanylin and Uroguanylin in the Digestive System
… Those active peptides activate the guanylyl cyclase C (GC-C) receptor from the lumen and catalyse the production of the intracellular secondary messenger cGMP. Subsequently cGMP stimulates both cGMP- dependent protein kinase II (PKGII) and protein kinase A (PKA). Both PKGII and PKA …
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Studies of the effect of cysteine and heme pocket mutations of the nitric oxide dioxygenase and nitrite reductase activities of human Cytoglobin and Androglobin heme domain
… human globin, but similar to that observed with guanylate cyclase, cytochrome c’. Adgb-GD displays a high nitrite reductase activity, which is influenced by the redox state of the disulfide bond. Spectra characterisation depicts Adgb-GD as a hexacoordinate globin, comparative spectra analysis …
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A Comparative Study of Sensory Neuron Synaptic Activity and the Role of Presynaptic Diversity, Specificity, and Regulation in Caenorhabitis Elegans
… preference. We identify the receptor-type guanylate cyclase gcy-28 and Gqα as additional important regulators of AWC<sup>ON</sup> synaptic release, and identify unc-31 (CAPS) as an additional genetic determinant of butanone olfactory preference. Finally, we suggest a model for a dual …
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Relaxin: a new cardiovascular hormone in humans? Comparative potency and mechanisms of action
… messenger system is also important. ODQ, (a guanylate cyclase inhibitor) (n=10) reduced relaxin’s action while zaprinast, (a cGMP phosphodiesterase inhibitor) (n=7) enhanced relaxin’s action. Manipulation of nitric oxide with L-NAME (n=8) and L-NOARG (n=10), nitric oxide synthase (NOS) …