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Showing 1 to 6 of 6 for “"Guanylate Binding Proteins"”.
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The Role of Human Guanylate Binding Proteins in Host Defense and Inflammation
… invasion, host cells employ numerous defense proteins to limit microbial growth and mediate pathogen destruction. Among these host defense proteins are a number of dynamin-like GTPases expressed in response to the cytokine Interferon-gamma, including the p65 Guanylate Binding Proteins (GBPs). …
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Functional analysis of Shigella encoded IpaH E3 ubiquitin ligases in cell-autonomous immunity
… pathways. My work demonstrated that IFN-induced guanylate-binding proteins (GBPs) are novel targets for IpaH9.8. GBPs inhibit actin-dependent motility and cell-to-cell spread of bacteria unless they are ubiquitylated by IpaH9.8 and consequently degraded by the proteasome. IpaH9.8 targets GBP1, …
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Elucidating Human Inflammasome Responses To Legionella Pneumophila And Lipopolysaccharide Variants
… a family of IFN-inducible GTPases known as guanylate binding proteins (GBPs) promote inflammasome responses to a variety of bacteria in mice. The functions of the mouse GBPs include stimulating the rupture of pathogen-containing vacuoles and bacteriolysis of cytosolic bacteria in order to …
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The Role of Galectin-3 in Pathogen Sensing and Cell Autonomous Defense
… host cytosol. Galectins, cytosolic host glycan binding proteins, are then able to recognize the exposed sugars and bind them. Subsequently, host defense proteins including the guanylate binding proteins (GBPs) are recruited to the damaged membrane. I propose that this damage sensing ability is …
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Interferon-Inducible GTPases as Positive and Negative Regulators of Inflammasomes
… families of interferon-inducible GTPases: the guanylate-binding proteins (GBPs) and the immunity related GTPases (IRGs). Previous studies have associated these proteins with immune regulation, but many questions remain surrounding their functions. </p><p>In the first part of this dissertation, …
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Charakterisierung von Tumorantigenen des kutanen T-Zell Lymphoms: Serologische Immunantwort und Expressionsanalyse
Immuntherapien auf der Basis gut charakterisierter, tumorspezifischer Antigene stellen ein vielversprechendes Konzept der Tumortherapie dar. Ein potentielles Antigen für immuntherapeutische Strategien sollte möglichst tumorspezifisch exprimiert sein und es sollte einen Hinweis auf bereits erfolgte …