Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Guanosine triphosphatase"”.
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Heterotrimeric G protein beta:gamma bound to a biologically active peptide : structural definition of a preferred protein interaction surface
… are composed of α, β, and γ subunits. Gα is a guanosine triphosphatase (GTPase); Gβ and Gγ have no intrinsic enzymatic activity and form an obligate heterodimer that participates in independent signaling interactions when released from Gα. Gβγ signaling partners include Gα, phosphotidylinositol …
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Control of perineurial glial growth in Drosophila melanogaster
… in accordance with its role as a Ras guanosine triphosphatase activating protein (Ras GAP), acts to down regulate Ras activity to control perineurial glial growth. My work suggests that loss of neurofibromin leads to an increase in Ras activity in the peripheral glia that, in …
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Rapid Rac GTP-ASE activation in live cells by mechanical stress is independent of Src
… temporal and spatial activation of Rac, a small guanosine triphosphatase, was quantified using a fluorescent resonance energy transfer (FRET) method that measures changes in Rac activity in response to mechanical stresses by quantifying intensity ratios of ECFP (enhanced cyan fluorescent protein …
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Preclinical Investigation of Mitochondrial Fission Inhibitors in Pulmonary Arterial Hypertension and Non-Small Cell Lung Cancer
… via in silico screening predicted to bind DRP1's guanosine triphosphatase (GTPase) domain. We hypothesize that inhibition of DRP1's GTPase activity by the novel DRP1 inhibitor, 2-(2-Phenyl-2-propanyl)-1,2-benzothiazol-3(2H)-one 1,1-dioxide (Compound 6) can suppress NSCLC and PAH phenotypes in …
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Analysis of SMAUG1 protein motifs and interacting partners - linking regulation of phase separation to human disease
… cell structure integrity, cell motility and guanosine triphosphatase (GTPase) enzyme regulation. Collectively, this thesis establishes SMAUG1 as a dynamically regulated phase-separating RBP that integrates intrinsic sequence features and interactions with 14-3-3 proteins to modulate phase …