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Showing 1 to 9 of 9 for “"Guanine nucleotides"”.
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The effect of guanine nucleotides on glucagon-sensitive adenylate cyclase in the rat heart
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Polarizable Simulations of the bcl-2 DNA G-Quadruplex and FMRP RNA G-Quadruplex:Duplex Junction Binding Protein
… can form in regions of nucleic acids rich in guanine nucleotides. The guanine bases form a square planar conformation via Hoogsteen hydrogen bonding. These stacked tetrads have inward-facing carbonyl oxygens, facilitating the coordination of ions. Improper GQ conformations can lead to improper …
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MOLECULAR FACTORS THAT INFLUENCE THE BINDING OF AGONISTS TO AMPA RECEPTORS
… mechanisms responsible for this. Additionally, guanine nucleotides competitively inhibit AMPA receptors and a second goal has been to further characterize guanine nucleotide binding, and to create mutations that selectively diminish this so that the function of the inhibition can be evaluated. A …
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Activated RhoA Positively Regulates Exchange Activity of PDZ-RhoGEF
… GTP-bound state. This cycle is mediated by guanine nucleotide exchange factors (GEFs) that increase the rate of dissociation of GDP by stabilizing the nucleotide-free state of the GTPases via their DH/PH domains; this facilitates binding of GTP and activation of the protein. The RGS …
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The regulation of luteinizing hormone exocytosis in α-toxin permeabilized sheep anterior pituitary cells
… exocytosis in other cell systems, the effects of guanine nucleotides on LH exocytosis were examined. At resting cytosolic [Ca²⁺]free (pea 7), the GTP analogues GTPyS and GMPPNP stimulated LH exocytosis with similar potencies (EC₅₀ 20-50 μM). Additional experiments indicated that the effects of …
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Characterization of the Saccharomyces cerevisiae gene MGP1, a novel member of the ras gene superfamily that functions in the mitochondrial biogenesis
… homology in the regions known to interact with guanine nucleotides. Multiple copies of MGP1 suppress the respiratory enzyme assembly defects caused by msg1 mutations. To demonstrate that Mgp1p is functionally similar to p21[superscript] ras-related proteins, a mutation was introduced into MGP1 …
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Single-molecule G-quadruplex visualisation in live cells and 3D chromatin
… DNA structure formed by the self-assembly of guanine nucleotides. Mapping G4 formation in the human genome shows that they are enriched in functionally important regions such as promoters, enhancers, transcription factor and architectural protein binding sites. However, the roles of G4s in …
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Structure of T6SS components and assessment of potential Gram-ve drug targets
… in chapter 7. This protein controls the pool of guanine nucleotides within cells. Fragments were identified using bio-layer interterformetry, a label free optical analytical technique that monitors biomolecular interactions in real time. Fragments were assessed for inhibitory effects using enzyme …