Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Guanine nucleotide exchange factors (GEFs)"”.
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Determining the differential roles of the dock family of GEFs in drosophila development
… Dock proteins function as unconventional guanine nucleotide exchange factors (GEFs). Upon binding to ELMO (Engulfment and cell motility) proteins, Dock-ELMO complexes activate the Rho family of small GTPases to mediate a diverse array of biological processes, including cell motility, …
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Upregulation of PIP3-dependent RAC Exchanger 1 (P-Rex1) Promotes Prostate Cancer Metastasis
Activation of Rac by guanine-nucleotide exchange factors (GEFs) at the leading edge of the cell plays an important role in directional cell migration, a critical step of tumor metastasis cascades. We investigated the role of P-Rex1, a novel specific GEF for Rac, in human prostate cancer metastasis. …
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Activated RhoA Positively Regulates Exchange Activity of PDZ-RhoGEF
… GTP-bound state. This cycle is mediated by guanine nucleotide exchange factors (GEFs) that increase the rate of dissociation of GDP by stabilizing the nucleotide-free state of the GTPases via their DH/PH domains; this facilitates binding of GTP and activation of the protein. The RGS …
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The Rac-GEF P-Rex1 Regulates Agonist-Induced GPCR Trafficking
P-Rex guanine-nucleotide exchange factors (GEFs) activate the small GTPase Rac following stimulation of a variety of cell surface receptors, including G protein-coupled receptors (GPCRs). By activating Rac, P-Rex proteins control gene expression, cell survival and motility, among other responses, …
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Localization and Function of Bacterial Type III and IV Effector Proteins
… time. Bacterial effector proteins are virulence factors that are directly secreted from the bacteria into the host cytosol and function to rewire eukaryotic signaling networks to establish an environment for bacterial survival. While much effort has gone into substrate identification and …
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Regulation of Guanine Nucelotide Exchange in Inhibitory G Protein Alpha Subunit by Activator of G Protein Signaling 3 and Novel Regulatory Peptides
The release of GDP from the nucleotide binding pocket of G protein a subunit (Ga) is accelerated by guanine nucleotide exchange factors (GEFs) and inhibited by guanine nucleotide dissociation inhibitors (GDIs). The beta gamma subunit of heterotrimeric G protein and GoLoco motif are GDIs. Activator …
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Modulation of host phosphatidylinositol phosphates by salmonella effector protein SOPB
… having 69% sequence identity are known to be guanine nucleotide exchange factors (GEFs). SopE is a GEF capable of activating both Rac1 and Cdc42 while SopE2 activates Cdc42 only. SopB is a known phosphatidylinositol phosphate phosphatase possessing both 4- and 5-phosphatase activities …
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Linking WRP/srGAP3 to the Cognitive Deficits in 3p- Syndrome and Its Role in the Regulation of Dendritic Filopodia Formation
… and negative regulatory proteins: the activating guanine nucleotide exchange factors (GEFs) and the deactivating GTPase activating proteins (GAPs). The WAVE-associated Rac GAP (WRP) is thought to regulate key aspects of synapse development and function, and has been implicated in a form of mental …
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Exploring the Importance of PREX Proteins in Glucose Homeostasis and Insulin Signalling
PREX protein family (PREX1 and PREX2) guanine-nucleotide exchange factors (GEFs) activate the small G protein Rac. They are important in many physiological and pathophysiological processes, including inflammation, neuronal plasticity, cancer progression and metastasis, with an exciting new role in …
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Identification and Characterization of Novel Mechanisms of Functional and Structural Synapse Remodeling: Focus on Vav Guanine Nucleotide Exchange Factors and MEF2 Transcription Factors
… of this study, I identify a novel role for Vav guanine nucleotide exchange factors (GEFs) in brain-derived neurotrophic factor (BDNF)-dependent synapse plasticity. BNDF and its receptor, TrkB, are well-established positive modulators of hippocampal long-term potentiation (LTP), and increasing …
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The WXXXE Effector Map Functions as a Potent and Specific Guanine Nucleotide Exchange Factor for CDC42
… activity of GTPases is the conversion of bound guanine triphosphate (GTP) to guanine diphosphate (GDP) via the hydrolysis of the gamma phosphate. The oscillation between the "off" or GDP-bound form and the "on" or GTP-bound form is facilitated by the action of GTPase activating factors (GAPs) …
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Redefining the specificity of phosphoinositide-binding by human PH domain-containing proteins
… domains should bind PIPs with some specificity. Guanine nucleotide-exchange factors (GEFs) catalyze the GTP-bound active state of small G proteins. The Rho family of small G proteins are activated by a large family of proteins containing Dbl-homology (DH) domain, called RhoGEFs, which are known …
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Primordial imperatives and the evolution of control of endolysosomal trafficking
… function of the endo-lysosomal machinery and the guanine nucleotide exchange factor Mon1-Ccz1 Endo-lysosomal dynamics have evolved to impact diverse physiological processes including, retrograde axonal transport(Deinhardt et al., 2006), and immune activation and antigen loading on MHC-II(Fairn and …