Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Guanine Nucleotide Exchange Factors"”.
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Regulation of rho guanine nucleotide exchange factors through lipid binding and phosphorylation
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2027-08-01
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Identification of a family of cAMP-binding guanine nucleotide exchange factors by Gregory M. Springett.
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1998.
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Identification and Characterization of Novel Mechanisms of Functional and Structural Synapse Remodeling: Focus on Vav Guanine Nucleotide Exchange Factors and MEF2 Transcription Factors
… of this study, I identify a novel role for Vav guanine nucleotide exchange factors (GEFs) in brain-derived neurotrophic factor (BDNF)-dependent synapse plasticity. BNDF and its receptor, TrkB, are well-established positive modulators of hippocampal long-term potentiation (LTP), and increasing …
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Regulation of Net1A Subcellular Localization By The Small Gtpase Rac1
… is stimulated by a family of enzymes known as guanine nucleotide exchange factors (Rho GEFs). The neuroepithelioma transforming gene 1 (Net1) is a Rho GEF specific for the RhoA subfamily that is overexpressed in primary breast tumors and breast cancer cell lines. Net1 isoform expression is also …
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Determining the differential roles of the dock family of GEFs in drosophila development
… Dock proteins function as unconventional guanine nucleotide exchange factors (GEFs). Upon binding to ELMO (Engulfment and cell motility) proteins, Dock-ELMO complexes activate the Rho family of small GTPases to mediate a diverse array of biological processes, including cell motility, …
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Regulation of p190RhoGEF by Activated Rho and Rac GTPases: Amplification and Crosstalk
… of Rho proteins largely depends on Rho Guanine nucleotide Exchange Factors (RhoGEFs), which catalyze the exchange of GTP for GDP on Rho. For classical RhoGEFs, the exchange activity resides in a Dbl homology (DH) domain, which is linked to a pleckstrin homology (PH) domain that subserves …
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Modulation of mitotic progression and cell cycle checkpoints by phosphorylation-dependent protein-protein interactions
… kinase regulation of cytokinesis-specific guanine-nucleotide exchange factors for the small G-protein Rho is necessary for proper actomyosin ring contraction and cytokinesis. Additionally we demonstrate that Polo-like-kinase-1 directly regulates the activity of the Rho-effector-kinase …
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Upregulation of PIP3-dependent RAC Exchanger 1 (P-Rex1) Promotes Prostate Cancer Metastasis
Activation of Rac by guanine-nucleotide exchange factors (GEFs) at the leading edge of the cell plays an important role in directional cell migration, a critical step of tumor metastasis cascades. We investigated the role of P-Rex1, a novel specific GEF for Rac, in human prostate cancer metastasis. …
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Activated RhoA Positively Regulates Exchange Activity of PDZ-RhoGEF
… GTP-bound state. This cycle is mediated by guanine nucleotide exchange factors (GEFs) that increase the rate of dissociation of GDP by stabilizing the nucleotide-free state of the GTPases via their DH/PH domains; this facilitates binding of GTP and activation of the protein. The RGS …
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Evaluation of Chronic RalGTPase Activation as a Core Specifier of Oncogenic Transformation
… activated via the Ras effector family Ral guanine nucleotide exchange factors (RalGEFs). Previous studies have demonstrated that RalA and RalB collaborate to maintain tumorigenicity through regulating both proliferation and survival. Remarkably, RalB is specifically required for survival in …
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Structure-function Analysis of the STRIPAK Complex
… and kinase interactors, including a family of guanine nucleotide exchange factors and protein phosphatase 6 (PP6).
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The Rac-GEF P-Rex1 Regulates Agonist-Induced GPCR Trafficking
P-Rex guanine-nucleotide exchange factors (GEFs) activate the small GTPase Rac following stimulation of a variety of cell surface receptors, including G protein-coupled receptors (GPCRs). By activating Rac, P-Rex proteins control gene expression, cell survival and motility, among other responses, …
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Localization and Function of Bacterial Type III and IV Effector Proteins
… time. Bacterial effector proteins are virulence factors that are directly secreted from the bacteria into the host cytosol and function to rewire eukaryotic signaling networks to establish an environment for bacterial survival. While much effort has gone into substrate identification and …
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Regulation of Guanine Nucelotide Exchange in Inhibitory G Protein Alpha Subunit by Activator of G Protein Signaling 3 and Novel Regulatory Peptides
The release of GDP from the nucleotide binding pocket of G protein a subunit (Ga) is accelerated by guanine nucleotide exchange factors (GEFs) and inhibited by guanine nucleotide dissociation inhibitors (GDIs). The beta gamma subunit of heterotrimeric G protein and GoLoco motif are GDIs. Activator …
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Modulation of host phosphatidylinositol phosphates by salmonella effector protein SOPB
… having 69% sequence identity are known to be guanine nucleotide exchange factors (GEFs). SopE is a GEF capable of activating both Rac1 and Cdc42 while SopE2 activates Cdc42 only. SopB is a known phosphatidylinositol phosphate phosphatase possessing both 4- and 5-phosphatase activities …
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From Cell Shape to Body Shape: Epithelial Morphogenesis in Drosophila melanogaster
… Rho-family GTPases that are activated by Rho guanine nucleotide exchange factors (RhoGEFs) play an important role in this process. The present thesis investigates the mechanisms that control activation and specificity of the GTPase Rho1 by DRhoGEF2 during morphogenesis of the Drosophila …
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Linking WRP/srGAP3 to the Cognitive Deficits in 3p- Syndrome and Its Role in the Regulation of Dendritic Filopodia Formation
… and negative regulatory proteins: the activating guanine nucleotide exchange factors (GEFs) and the deactivating GTPase activating proteins (GAPs). The WAVE-associated Rac GAP (WRP) is thought to regulate key aspects of synapse development and function, and has been implicated in a form of mental …
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Exploring the Importance of PREX Proteins in Glucose Homeostasis and Insulin Signalling
PREX protein family (PREX1 and PREX2) guanine-nucleotide exchange factors (GEFs) activate the small G protein Rac. They are important in many physiological and pathophysiological processes, including inflammation, neuronal plasticity, cancer progression and metastasis, with an exciting new role in …
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R-RAS41A fusion protein purification and the cloning of a new RAS GEF like gene
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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The WXXXE Effector Map Functions as a Potent and Specific Guanine Nucleotide Exchange Factor for CDC42
… activity of GTPases is the conversion of bound guanine triphosphate (GTP) to guanine diphosphate (GDP) via the hydrolysis of the gamma phosphate. The oscillation between the "off" or GDP-bound form and the "on" or GTP-bound form is facilitated by the action of GTPase activating factors (GAPs) …
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