Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 3 of 3 for “"Guanine Exchange Factors"”.
-
Characterization of Novel Substrates of the Tankyrase and RNF146 Destruction Complex and Mechanisms of its Regulation
… of RNF146. I have shown that both substrates are guanine exchange factors for the small GTPase Rab11a. I have defined the minimal catalytic core of SH3BP5/L and shown it to be composed of a novel two α-helix GEF domain. My work has demonstrated that SH3BP5 and SH3BP5L are both required for optimal …
-
Prenylation-independent activation of RhoA and Rac1: Effects on localization and neurite outgrowth
Rho family guanine nucleotide triphosphatases (GTPases) are molecular switches that play a fundamental role in axon growth and guidance by directing growth cone cytoskeletal changes through interaction with downstream effectors. Small GTPases are considered active when bound to guanosine …
-
Biophysical characterization of KO513, a protein expressed in human invasive glioblastoma
… GTPase family, membrane proteins, transcription factors and neurotransmitters. The overall in silico analysis suggest that K0513 may possess nucleotide exchange factor (NEF) activity for Rab3a. Recombinant proteins, non-codon harmonized (K0513W) and codon harmonized (K0513H) were expressed in E. …