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Showing 1 to 20 of 30 for “"Guanidinium"”.
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Guanidinium Compounds: Synthesis, Oxoanion Binding, and Cellular Delivery
… with the cell surface through bidentate guanidinium–oxoanion hydrogen bonds. Depending on conditions, this interaction guides the uptake of the CPP and its cargo through direct translocation or endocytosis. In Chapter 1, I summarize literature that is relevant to this thesis. In Chapter …
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Synthesis of guanidinium-functionalized amphiphiles for the exploration of chaotropic supramolecular nanoribbons
… of water dynamics by attaching a chaotropic guanidinium head group. This head group will disturb the hydrogen bonding network of surrounding water, causing a measurable change in water dynamics when analyzed using Overhauser Dynamic Nuclear Polarization. Guanidinylation was achieved, but …
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Proteinpolysaccharides from Bovine Nasal Cartilage Interactions with Glycoproteins and the Formation of Aggregates
… with concentrated salt solutions (typically 4 M guanidinium chloride), 85% of the total proteinpolysaccharide in the tissue is easily solubilized. The collagen framework of the tissue remains intact during the extraction procedure, and the cartilage slices retain their shapes. The amount of …
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Validation of the charge equilibration lipid force field for simulations of phospholipid membranes with an application to the study of the free energetics of methyl guanidinium permeation across a DPPC bilayer
… of an arginine side-chain analog, methyl guanidinium, as it crosses a DPPC lipid bilayer. Combining umbrella sampling MD simulations with the Weighted Histogram Analysis Method (WHAM) for unbiasing probabilities, we compute a potential of mean force (PMF) for the reversible trans-fer of …
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The Effect of the Secondary Coordination Sphere on the Stabilities of Cerium(III) and Cerium(IV) Coordination Complexes
… and potassium, as well as hydrogen bonding guanidinium cations, as a framework to guide lanthanide-ligand bonding interactions was studied. This work can be applied to lanthanide coordination and redox chemistries.
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Rational Design of Novel Halide Perovskites Combining Computations and Experiments
… hybrid perovskites containing the guanidinium cation Gua$_x$PbI$_{x+2}$ (x = 1, 2 and 3, Gua = guanidinium, C(NH$_2$)$_3$). The conclusions and possible future work are summarized in Chapter 7. These results provide theoreticians and experimentalists with insight into the design and …
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Small molecule motion within and through organic nanomaterials: an anthology
… in Chapter 3 to induce pH responsiveness in a guanidinium headgroup moiety over a physiologically relevant pH range. Finally, Chapter 4 (completed under the supervision of Prof. Zachary Smith) explores molecular transport of CO₂ gas mixtures through a novel guanidinium-functionalized polymer of …
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Developing test strips for naked-eye detection of alpha-hydroxy acids using indicator-displacement assays: an application of molecular recognition
… scaffold incorporating boronic acid and guanidinium moieties as functional sensing components. The same assay was found to be useful in developing test strips for “naked-eye detection” of tartrate and other α-hydroxyacids, by treating filter papers and various polymer matrices with the …
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X-ray crystallographic studies of the nucleotide binding sites on adenylosuccinate synthetase mutants from Escherichia coli
… The void created by the elimination of the guanidinium group in the R143L mutant is filled by water molecules. In all three structures OD1 of Asp 13 coordinates Mg⁺², as well as hydrogen bonds with Ni of 6-phosphoryl-IMP. In addition, distances between Asp 13 and 6-phosphoryl-IMP decrease as …
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Development of nitroguanidine wastewater treatment technologies
… carbon. Strong acid resin was found to reduce guanidinium ion Gu⁺ concentration from 14.5 mg/L to 1 mg/L with a resin capacity of 0.13 eq Gu⁺ /L resin. No significant reduction in resin capacity for Gu⁺ was experienced after five regenerant cycles. A unique two-step regeneration was used. This …
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Functional Polymer Materials: From Iptycenes to Ring-Opening Polymerizations
… composite membranes towards aqueous filtration. Guanidinium-functionalized polymers are explored for impedance-based gas sensing. Pyrazolium-functionalized polymers are fabricated into anion-exchange membranes. In Chapter 2, we design a set of two- and three-component polyurethanes to elucidate …
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Physico-chemical studies of block copolymers in aqueous solution
… of cosolutes (NaCl, Na2HPO4/NaH2PO4, urea and guanidinium chloride) and cosolvents (methanol, ethanol, n-propanol, n-butanol and formamide) on the observed phase transition of poloxamers have been investigated using HSDSC. Sodium chloride, phosphate buffer, n-propanol and n-butanol favour …
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Kinetic, Mechanistic, and Inhibition Studies On the Deiminase Family of Enzymes
… catalyze a similar reaction, the conversion of a guanidinium to a ureido and ammonia, their substrates differ greatly, i.e., peptidyl-arginine versus agmatine (decarboxylated arginine). Interestingly, the dysregulation of these enzymes are involved in a number of diseases. Furthermore, it has been …
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Characterization of the unfolding, refolding, and aggregation pathways of two protein implicated in cataractogenesis : human gamma D and human gamma S crystallin
… have been characterized as a function of guanidinium hydrochloride (GdnHCl) concentration at neutral pH and 37⁰C, using intrinsic tryptophan fluorescence to monitor in vitro folding. Equilibrium unfolding and refolding experiments with GdnHCl showed unfolded protein is more fluorescent …
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Übertragung von BSE auf nicht humane Primaten als Modell für die variante Creutzfeldt-Jakob Erkrankung (vCJD) im Menschen
… Prion Proteins gegenüber einer Denaturierung mit Guanidinium Hydrochlorid wurden in demselben Tier abhängig von der Hirnregion unterschiedliche Stämme nachgewiesen. In bisher veröffentlichten Studien wurde ein Vergleich der Stabilität als Marker für Prionenstämme zumeist unabhängig von der …
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A New Approach to Drug Delivery: Non- Peptidic, High Load Macrocyclic Alternatives to Cell Penetrating Peptides
… is presented. Synthesis of an analogue featuring guanidinium groups on the upper rim was achieved using carboxybenzyl (Cbz) protecting groups as a less labile alternative to butoxycarbonyl (Boc) groups. The syntheses of analogues with varied linkers for attachment of the dye are also presented. …
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The role of crude saliva and purified salivary mucins in the inhibition of the Human Immunodeficiency Virus type 1
… in this assay. Mucus was extracted in 6M guanidinium hydrochloride and a cocktail of protease inhibitors, pH 6.5. Sepharose CL-4B gel filtration separated MUC5B and MUC7 in saliva. Mucins were purified by density gradient ultra-centrifugation in caesium chloride. Western blotting and amino …
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Insulin-like growth factor-I in growing horses and RNA isolation from small articular cartilage samples
… RNA extraction kits, with the third a modified guanidinium isothiocyanate/acid-phenol extraction procedure. The combined average yield for all protocols was 91.9 ng RNA/mg of cartilage. All protocols yielded a sufficient quantity of quality RNA suitable for gene expression analysis.
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The Rational Design, Synthesis, And Biological Evaluation Of Small Molecule Cd4 Mimetic Families For Hiv-1 Viral Entry Inhibition
… explore bioisoteric replacement of the lead’s guanidinium group at the 2-position of the indanone (Chapter 2), a 5,7-disubstituted pattern around the lead BNM-III-170 indanone core (Chapter 3), and incorporation of heterocyclic amines at C(5) of BNM-III-170.
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