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Showing 1 to 20 of 83 for “"Guanidine"”.
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The analytical chemistry of agricultural guanidine fungicides
A programme of research on agricultural guanidine fungicides, represented by a complex mixture of several components (guazatine) and by a single compound (dedine[?] ), was carried out. The studies involved the synthesis of several guanidine derivatives and their characterization by spectroscopic …
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The effects of methyl guanidine salts on the vagus nerve of the dog
Thesis (M.A.)--University of Kansas, Physiology, 1927.
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Increased Apoptosis in the Host By Guanidine Hydrochloride Treatment of Infectious Pancreatic Necrosis Virus
… been done with Bovine Herpes Virus (BHV) using guanidine hydrochloride (GuHC1) to extrude the DNA and leave the capsids intact. These 'created' empty capsids were used to demonstrate that attachment of the empty capsid induced apoptosis. Different strains of Reovirus, a naked double stranded RNA …
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Synthesis and utilization of guanidine catalysts for applications directed towards the preparation of butenolide and modified amino acid derivatives
Development of guanidine catalysts is explored through direct iminium chloride and amine coupling, alongside a 2-chloro-l,3-dimethyl-IH-imidazol-:-3-ium chloride (DMC) induced thiourea cyclization. Synthesized achiral catalyst N-(5Hdibenzo[ d,t][1,3]diazepin-6(7H)-ylidene)-3,5-bis(trifluoromethyl) …
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Synthesis and Determination of the Absolute Configuration of the Bicyclic Guanidine Core of Batzelladine A and the Development of a Novel [4+2] Inverse Electron Demand Hetero Diels -Alder Cycloaddition and Its Application Toward the Synthesis of the Tricyclic Guanidine Fragment Within Batzelladine A
… This includes the construction of the bicyclic guanidine portion including elucidation of the absolute configuration of the bicyclic guanidine and the development of a novel [4+2] inverse electron demand hetero Diels-Alder cycloaddition amendable for synthesis of the tricyclic guanidine portion. …
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Poliovirus Replication: Interactions with Cytoplasmic Membranes and with Compounds Which Affect Virus Biosynthesis
… Treatment of infected cells with 1.0 to 2.0 mM guanidine-HCl inhibits viral RNA synthesis, but does not measurably affect cellular metabolism. We have confirmed the observation that early guanidine treatment of cells infected with at least 50 PFU per cell of poliovirus does not block the …
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Synthesis and biological evaluation of 1,4-benzodiazepin-2-one analogues with antitrypanosomal activity
… relationships indicate that the inclusion of a guanidine moiety, a putative P-2 transporter motif, can improve the biological activity of these molecules. In vitro screening of these compounds showed a range of antitrypanosomal activities against T. b.brucei, with a number in the low micromolar …
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Polyandrocarpidines: Antimicrobial and Cytotoxic Compounds From the Marine Tunicate Polyandrocarpa Sp
… system, the other nitrogen is part of a primary guanidine function. It was advantageous to convert the guanidine to the dimethylpyrimidyl moiety by condensing with 2,4-pentanedione in the presence of sodium bicarbonate, because the dimethylpyrimidyl derivatives can be gas chromatographed, and the …
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Design, synthesis and mode of action of short biphenyl and anthranilamide cationic peptidomimetics
… that simple diaminoethanes and their respective guanidine cationic groups were sufficient to mimic lysine and arginine amino acids of natural antimicrobial peptides. The biphenyl backbone was important for antibacterial activity and tryptophan was important for bacterial cell membrane …
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Development of a Diastereoselective [4+2]-Annulation of Vinyl Carbodiimides With Chiral N-Alkyl Imines and Its Application to the Synthesis of the Batzelladine Alkaloids: Total Synthesis of (+)-Batzelladine a and (-)-Batzelladine D
… the stereochemically rich anti-fused polycyclic guanidine cores of the batzelladine alkaloids. Application of this strategy, together with additional key steps such as a long-range directed hydrogenation and a diastereoselective intramolecular iodoamination, led to highly convergent total …
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Reconfiguring the side-chain functionality of cationic helical polypeptides toward maximized gene delivery capabilities
… with different side charged groups (amine and guanidine) and hydrophobicity, and to mechanistically unravel the effect of polypeptide structure on the gene delivery capability. Guanidine-containing polypeptides displayed superior membrane activities to their amine-containing analogues via the …
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The barrier functions of the cervical mucus plugs and purified mucins against a panel of HIV-1 strains in the contexts of cell-free and cell-to-cell infections
… plugs were collected from women in labour in 6 M guanidine hydrochloride with protease inhibitors. The cervical mucus plugs were solubilised in 6 M guanidine hydrochloride with protease inhibitors, centrifuged, dialysed against distilled water and lyophilized. The mucins were purified by caesium …
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A Promiscuous Path to Novel Guanidines: Arginine-Modifying Enzymes as Key Synthetic Players
… for the chemoselective (m)ethylation of various guanidine-containing molecules, including arginine analogues, derivatives, and oligopeptides. The process relies on the promiscuous methyltransferase SznE (or an engineered variant thereof) to transfer a methyl or ethyl group, from …
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An Approach to the Total Synthesis of the Protein Phosphatase 1 and 2A Inhibitor Microcystin -Lr
… route to the intermediate microcystin-LR-di-Boc-guanidine which can be converted to a constitutional isomer of microcystin-LR. Mass spectral analysis and HPLC retention time show the presence of microcystin-LR although a clean 1H NMR could not be obtained.
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Understanding Non-viral Nucleic Acid Delivery Vehicles with Different Charge Centers and Degradation Profiles
… mechanism for PGAAs, new no buffering capacity guanidine or methylguanidine containing poly(glycoamidoguanidine)s (PGAGs) were synthesized. PGAGs formed stable polyplexes with pDNA from N/P (# secondary amine or guanidine group on polymer backbone / # phosphate group on pDNA backbone) ratio 3. …
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Protein refolding via immobilisation on crystal surfaces
… solubilised in solutions containing urea or guanidine hydrochloride. The removal of these molecules from the protein environment is commonly utilised as a method for triggering refolding. A new method for the refolding of biomolecular species has been developed via the formation of Protein …
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Development and Investigation of the Fluorescence of Cyclopropenium Ions
… and boronium-substituted compounds. A novel guanidine-cyclopropenimine proton sponge with exceptional basicity is reported that was further utilized to develop a stable tetracoordinate boronium-substituted proton sponge. A large focus of this thesis was also placed on the development of the …
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Poly(glycoamidoamine)s: Understanding their Structure and Structure-Bioactivity Relationships
… was investigated by designing and synthesizing guanidine based polymer series analogues to galactarate and tartarate based PGAAs (<strong>G1</strong> and <strong>T1</strong>) which incorporate secondary amines as the charge type on the polymer backbone. The guanidine based polymer series, …
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Structural Study of Natural and Synthetic Polymers
… showed most denaturation agents, such as pH, guanidine hydrochloride and DTT, didn't denature zein. Temperature and SDS may cause some denaturation as suggested from the increase of the intrinsic viscosity; the change of intrinsic viscosity was not sufficient to indicate coil-like conformation.
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