Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Guanabenz"”.
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Guanabenz Reduces Hyperactivity and Neuroinflammation Caused by Latent Toxoplasmosis in Mice
… previously shown that the anti-hypertensive drug guanabenz reduces Toxoplasma cyst burden in the brains of BALB/c mice, providing a means to examine whether brain cyst depletion reverses behavioral changes. We used two mouse strains (BALB/c and C57BL/6) differing in their susceptibility to …
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In Vitro and In Silico Analysis of Osteoclastogenesis in Response to Inhibition of De-phosphorylation of EIF2alpha by Salubrinal and Guanabenz
… synthetic chemical agents such as salubrinal and guanabenz that are known to inhibit the de-phosphorylation of eIF2alpha, the role of phosphorylation of eIF2alpha in osteoclastogenesis was investigated in this thesis. The questions addressed herein were: Does the elevation of phosphorylated …
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Using Saccharomyces cerevisiae to characterise the in vivo effects of exposure to the prion-curing drug Tacrine and the fungal metabolite gliotoxin
… agents, Tacrine, 6-aminophenanthridine and Guanabenz on [PSI+] have been studied. The ability of all three drugs to cure [PSI+] has been demonstrated. From investigating the Tacrine mode of action, it appears that this drug may inhibit Hsp104p, a chaperone that is involved in prion …
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Central Alpha-Adrenoceptors and Behaviour
… for α2 receptors clonidine, guanfacin and guanabenz, caused marked sedation, inhibited the pinna reflex, and were slightly analgesic. Clonidine also inhibited 5-HT-induced head twitches and haloperidol-induced catalepsy. In general, α1 agonists such as methoxamine, had the opposite effect …
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The eIF2 phosphatase: characterization and modulation
… eIF2 phosphatases. Three compounds (Salubrinal, Guanabenz and Sephin1) have been proposed as eIF2 phosphatase inhibitors with potential use as therapeutic tools in protein misfolding diseases. However, their precise mechanism of action and their direct effect on the enzyme remains an open …