Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 91 for “"Growth restriction"”.
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Role of PABP4 in intrauterine growth restriction
… in pregnancies which exhibit intra-uterine growth restricted (IUGR) fetuses from e15.5, and an increased prevalence of late-gestational fetal death (akin to stillbirth). Stillbirth affects approximately 1 in 225 pregnancies in the UK, and IUGR is not only a major risk factor for stillbirth …
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Perinatal outcomes with fetal growth restriction according to hypertensive disorder in pregnancy
태아 발육 부전이 의심되는 환자에 있어 산전 진찰의 목적은 실제 성장 부전을 일으킬 수 있는 위험인자를 가진 산모들을 조기에 발견하고 산과적 중재를 통하여 신생아의 이환률과 사망률을 줄이는데 있다. 발육부전을 동반한 임신은 다양한 산과적 문제들이 합병되어 있는 경우가 많으며 병태 생리학적으로 전자간증 및 만성 고혈압 등의 고혈압성 질환과도 연관이 있다고 밝혀진바 있다. 하지만 발육부전과 임신성 고혈압 질환이 같이 있는 경우 각 질환의 유형에 따른 주산기 예후에 대한 예후를 직접적 비교 연구는 많지 않다. 본 논문에서는 태아 …
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Effects of dietary intervention on inflammation and intrauterine growth restriction in neonatal piglets
Intrauterine growth restriction (IUGR), a form of fetal malnutrition that leads to small for gestational age (SGA) infants, is a condition that affects 7.5 million children born worldwide. Infants affected by IUGR are more prone to lengthy hospital stays, repeated infections, and neurodevelopmental …
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Development in children born very preterm after intrauterine growth restriction with abnormal fetal blood flow
Delivery of fetuses with intrauterine growth restriction (IUGR) with abnormal umbilical artery blood flow in the second trimester represents a clinical dilemma. So far, no evidence based management protocols are available adressing when to deliver these fetuses. The high risk of hypoxia and fetal …
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Unsupervised Multi-Scale Analysis for the Identification of Placental Subtypes of Human Preeclampsia and Fetal Growth Restriction
Preeclampsia (PE) and fetal growth restriction (FGR) are two of the most common pathologies of pregnancy, both thought to be primarily driven by placental dysfunction. Despite decades of research into the underlying etiologies of these disorders, as well as potential biomarkers and treatments, no …
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Automated Detection of Maternal Vascular Malperfusion Lesions in Human Placentas Diagnosed with Preeclampsia and Fetal Growth Restriction Using Machine Learning
Introduction: Preeclampsia (PE) and fetal growth restriction (FGR) are common obstetrical complications, often with pathological features of maternal vascular malperfusion (MVM) in the placenta. Current placental clinical pathology methods involve a manual visual examination of histology sections, …
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Intrauterine growth restriction (IUGR) and birth outcomes in a cohort of HIV-infected pregnant women in Cape Town, South Africa
Background: Intrauterine growth restriction (IUGR) is a major contributory factor of perinatal morbidity and mortality. This suboptimal growth is associated with infants being small-for-gestational age. In addition to genetic and placental factors, maternal factors such as infection are also …
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Prediction and prevention of fetal growth restriction and compromise of fetal wellbeing: systematic reviews and meta-analyses with model based economic evaluation.
Restriction of fetal growth and compromise of its wellbeing remain significant causes of perinatal death and childhood disability. There is a lack of scientific consensus about the best strategies for predicting these conditions before birth and thus there is uncertainty about the best management …
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Impact of fetal growth discordance and selective fetal growth restriction on perinatal outcomes in dichorionic diamniotic twins: A systematic review and meta-analysis
Σκοπός: Η διερεύνηση της επίδρασης της ασυμφωνίας εμβρυϊκής ανάπτυξης και του εκλεκτικού περιορισμού της εμβρυϊκής ανάπτυξης (sFGR) στην περιγεννητική έκβαση σε δίδυμες κυήσεις διχοριακές διαμνιακές (DCDA). Μέθοδοι: Πραγματοποιήθηκε συστηματική ανασκόπηση και μετα-ανάλυση με χρήση των βάσεων …
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Preeclampsia Link to Gestational Hypoxia
… adverse effects on the offspring include fetal growth restriction, which is not only a major driver of perinatal morbidity, but also increases cardiometabolic risk in later life. In this thesis, we used bespoke isobaric chambers to induce hypoxia in sheep for the last third of pregnancy and …
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Axis of placental ageing in adverse pregnancy outcomes
… both maternal and fetal outcomes. Intrauterine growth restriction (IUGR) is defined as the inability of the fetus to reach normal growth potential within the uterus as a result of various genetic, environmental, or placental factors. Premature ageing of the placenta in pregnancy outcomes such as …
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Muscle Growth and Development in Intrauterine Growth Restricted Pigs
Intrauterine growth restriction causes impaired growth and development of mammalian fetus, and leads to long-term negative effect on postnatal growth. Among domestic animals, pigs exhibit the most severe naturally occurring IUGR and reduced postnatal muscle growth. The objectives of this research …
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Role of Chlamydia trachomatis infection in adverse pregnancy outcomes
… controversial data on miscarriage, intrauterine growth restriction and low birth weight, however the causative mechanisms are unknown. A successful pregnancy requires normal endometrial stromal cell (ESC) decidualisation and trophoblast invasion, processes that involve chemokine action and lead …
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Pareto Task Inference Analysis of Single-Cell RNASequencing of Human Placenta Reveals Biological Insightsinto Adverse Pregnancy Outcomes
… outcomes (APOs), such as preeclampsia, fetal growth restriction, and preterm birth, occur in 10-15% of pregnancies. There is limited knowledge of how the cellular states in the placenta and decidua tissues are altered in women with particular APOs or may contribute to APOs. Single-cell RNA …
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Aggregatibacter actinomycetemcomitans serotypes in gingival crevicular fluid of mothers delivering preterm.
… is a direct consequence of PTB or intrauterine growth restriction, and is a major determinant of neonatal infant morbidity and mortality. The primary aim of this study was to determine if the prevalence of Aggregatibacter actinomycetemcomitans (Aa) serotypes in gingival crevicular fluid (GCF) …
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Intrauterine effects of maternal weight dynamics
… to play an aetiological role in fetal growth restriction and the development of preeclampsia. This thesis aims to investigate the association between maternal weight dynamics and both cardiovascular adaptation to pregnancy and related perinatal outcomes. First, a meta-analysis was …
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Effect of Inflammation in Pregnancy on Maternal and Offspring Cardiovascular Systems
… rodent models of pregnancy loss and fetal growth restriction to assess the effects of aberrant inflammation during pregnancy and subsequent high fat diet consumption on cardiac function, morphology, and biomarkers of CVD in mothers and offspring. In the maternal study, pregnant C57BL/6 mice …
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Maternal Cardiac Autonomic Function and Fetal Behaviour in Hypertensive and Obese Pregnancies
… with placental insufficiency and fetal growth restriction, whereas obesity in pregnancy is associated with placental inflammation and macrosomia. Fetal growth restriction is associated with an increased risk for language deficits at 2-5 years of age. However, maternal cardiac autonomic …
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Placental (Mal)Adaptation in Maternal Obesity: Immune-Mediated Regulation of Placental Nutrient Partitioning and Fetal Growth
… effects of the gestational environment on fetal growth and serves as a critical determinant of long-term offspring health. This project aims to investigate how maternal obesity, and inflammation may disrupt placental nutrient partitioning potentially leading to fetal growth restriction. To …
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Early life origins of the insulin resistance syndrome in the aged guinea pig.
In human populations, perturbed growth in early life and ageing have been identified as risk factors for the development of Insulin resistance syndrome (IRS). The consequences of restricted prenatal growth on postnatal function have been investigated using numerous experimental models of …
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