Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"Growth regulation"”.
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Role of MDM2 In Cell Growth Regulation
… an immortal cell line that is non-responsive to growth arrest by the cyclin A inhibitory domain. This suggests that induction of MDM2 leads to G1 arrest by at least two independent mechanisms, and multiple genetic damages are necessary to overcome MDM2-mediated growth arrest. To determine novel …
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Role of the Ajuba LIM Proteins in Epithelial Growth Regulation
… and a novel regulator of epithelial organ growth as a component of the conserved Hippo pathway, which has been implicated in both tissue size control and cancer development. djub-deficient epithelial tissues were small due to decreased cell numbers resulting from increased apoptosis and …
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Growth regulation of prostate cancer by the intracellular protein tyrosine kinase 6.
Growth regulation of prostate cancer by the intracellular protein tyrosine kinase 6.
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High precision mass-based assay to examine growth regulation of the cell cycle
… insight into the metabolic mechanisms and regulation of cell cycle processes. Though size is considered to be a fundamental property of cell state, its measurement on a single-cell basis with high-resolution has been elusive primarily due to enormous experimental barriers. This thesis …
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Dietary Effects on the Stoichiometry of Growth, Regulation, and Wastes of Ozark Stream Insect Detritivores
… of diet nutrient content and leaf litter type on growth, regulation, and wastes of aquatic invertebrate detritivores. I tested effects of leaf litter diet carbon:phosphorus (C:P) on growth and stoichiometric regulation of the detritivorous caddisfly Pycnopsyche lepida and used results to determine …
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Growth regulation in the protozoan parasite Trypanosoma brucei: Evidence of tyrosine-specific protein kinase activity
… is an important mechanism for regulating cell growth and proliferation in metazoan organisms. This phosphorylation is conducted by a tyrosine-specific protein kinase. The activation of tyrosine kinases is an important step in transducing extracellular signals to a cell's interior. Until …
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Combination effect of ACP 2100, imazaquin and triclopyr on common dandelion and three Kentucky bluegrass turf types
… for use in a turf management program, including growth regulation and broadleaf weed control. Field and greenhouse results indicated an antagonistic interaction between triclopyr and imazaquin for control of common dandelion (<i>Taraxacum officinale</i> Weber in Wigger). Addition of imazaquin at …
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Hyperactive Rac1 Drives MAPK-Independent Proliferation in Melanoma by Assembly of a Mechanosensitive Dendritic Actin Network
… cells use a variety of mechanisms to subvert growth regulation and overcome environmental challenges. Often, these same mechanisms enable cancer cells to develop resistance to targeted therapies. Here, we describe how a hyperactivating mutation of the Rac1 GTPase (Rac1P29S) harnesses Rac1's …
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The relationship of glycolytic/gluconeogenic intermediates in brewing yeast (Saccharomyces uvarum) fermentations to growth
… the metabolic interrelationship between yeast growth, regulation of glycolytic/gluconeogenic flux and accumulation of glycosyl donors for polysaccharide synthesis in brewing yeast (Saccharomyces uvarum) fermentations. Loss of fermenting power of a brewing yeast population may be created by a …
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Cell Polarity Regulates Organ Growth Through The Hippo Pathway
… Crumbs, can lead to uncontrolled tissue growth. Cells mutant for the basolateral determinant <em>scribble </em>overproliferate and can form neoplastic tumors. Interestingly, <em>scribble </em>mutant clones that arise in wild-type tissues are eliminated and therefore do not manifest their …
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Regulation of cellular growth and identification of stromal gene signatures in breast cancer
… are disrupted, resulting in uncontrolled cell growth. Regulation of RNA stability and turnover is important to maintain cellular homeostasis and can be controlled by various mechanisms. During stress, the cell can form cytoplasmic complexes of proteins and RNAs, called stress granules, to …
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Endoribonuclease toxin-antitoxin systems in bacteria : targets and growth inhibition
… that can reversibly inhibit the host bacteria's growth. Both toxin and antitoxin are encoded together on an operon and the antitoxin directly binds the toxin, preventing its activity. Under stressful conditions, the antitoxin may be degraded, allowing the toxin to inhibit growth. Bacteria often …
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The Synthesis, Characterization, Spectroscopic and Biological Activity Studies of Pt(Ii) and Pd(Ii) Cyanoximates
… Substantial biological activity (growth regulation, antimicrobial, pesticide detoxifying) was also found during the last two decases of investigations of cyanoximes. An attempt has been made to combine useful properties of both classes of compounds in order to create a new group of …
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Insulin and TOR pathways regulate cellular and organismal growth through the myc oncogene in Drosophila
… Drosophila the involvement of Insulin pathway in growth regulation, probably due to its role in glucose and lipid import, nutrient storage, and translation of RNAs implicated in ribosome biogenesis (Vanhaesebroeck et al. 2001). Moreover several lines of evidence implicate this pathway as a causal …
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Decoding Breast Cancer Development Through Single Cell and Spatial Genomics
… reducing cell adhesion, RNA processing, cell growth regulation and secretion pathways. Together, our data highlight extensive microenvironmental remodeling in DCIS that persists in invasive progression, providing new insights for risk stratification and targeted therapy development.</p>
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Quantitative Fluorescence Studies in Living Cells: Extending Fluorescence Fluctuation Spectroscopy to Peripheral Membrane Proteins
… trafficking, cellular signaling, and cell growth/regulation. Building accurate biophysical models of these processes requires quantitative characterization of the behavior of peripheral membrane proteins, yet methods to quantify their interactions inside living cells are very limited. …
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Regulation of Growth and Branching of Containerized Penstemon x mexicali Cultivars
… this research are to analyze the effects plant growth regulators and pinching practices have on the growth habit of Penstemon x mexicali Pikes Peak Purple and Red Rocks and to produce more marketable containerized Penstemon. A preliminary study analyzed the effects branching agent PGRs had on …
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Recapitulation of Human Placental Insufficiency in a Novel Mouse Model :New Paradigm in Translational Research
… ligation (MUAL) reliably resulting in fetal growth restriction (FGR).Methods: At 18 days, timed mated C57BL/6J dams were divided into two groups: MUAL(n=18) ; and control-sham operated (n=18) with uterine horn fetal positions matched to each MUAL fetus. Pups were delivered on day 20, …
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The effect of timing of growing season drought on flowering of Andropogon gerardii
… different mechanisms (e.g. carbon gain via rapid growth early in the growing season vs. direct effects on stalk elongation later in the growing season). In order to test the differential effects of precipitation timing, rainfall deficits (100% exclusion) at different periods of the growing season …
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The Hormonal Regulation of Growth of Suspension Cultures of Acer pseudoulatanus L. cells
… may be both the cause and the effect of certain growth processes. In the whole plant one such process which has been linked to autocatalysis is xylogenesis. Autocatalysis has been implicated in the cell-death hypothesis (Sheldrake, 1973) and requires tha.t IAA is produced as a result of high …
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