Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Growth plate"”.
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Effectiveness of surgical versus conservative treatment for distal femoral growth plate fractures: a systematic review
Injury to the distal femoral growth plate in children is typically due to a high-energy trauma such as contact sports or motor vehicle accidents. There is no clear evidence as to whether surgery or application of a plaster or splint is the best option for these injuries in terms of growth arrest …
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The cellular and molecular mechanisms of glucocorticoid-induced growth retardation
… effects. Long-term use of GCs can result in growth retardation during childhood due to their actions on growth plate chondrocytes, although the exact mechanisms involved are unclear. The work of this thesis has investigated the cellular and molecular mechanisms involved in mediating GC …
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Pocket protein family function in mesenchymal tissue development and tumorigenesis
… proliferation of chondrocytes in the growth plate contributed to the phenotype. Mutant adult mice displayed an exacerbated cartilage and growth plate phenotypes, which corresponded to ectopically proliferating growth plate chondrocytes and altered chondrocyte differentiation. Notably, …
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Impact of the DNA methyltransferase inhibitor, 5-azacytidine, on chondrocytic phenotype
… effects of 5-aza on equine articular and growth plate chondrocytes. More specifically, we studied whether 5-aza administration directly stimulated expression of hypertrophic genes in articular and growth plate chondrocytes, and whether 5-aza administration affected the phenotypic responses …
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FRACTURE HEALING IN A RABBIT MODEL: A STUDY OF OSTEOCALCIN LOCALISATION
… and mineralised bone ’tutrix, but not in growth plate chondrocytes or cartilage matrix. Fracture healing studies showed morphologically typical, osteocalcin-producing osteoblasts lining newly forming trabeculae. Cells in the endosteum and in the cambium layer of the periosteum stained …
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A Novel Role for HAPLN1 in Skeletal Development
… spinal curvature that occurs during rapid growth and has a multi-factorial genetic etiology. Prior genetic studies in humans and animal models support differences in cartilage development in the pathogenesis of AIS. Here, we performed genome sequencing in families with inherited AIS and …
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Regulation of chondroprogenitor cell gene expression and migration
… in chondrogenesis markers, but markers of growth plate differentiation, including type X collagen, were either restricted or repressed, whilst expression of genes rich in articular cartilage were upregulated. This suggests that the enhanced ATDC5 model is more reminiscent of articular …
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Mineralized collagen biomaterials for studying bone biology in vitro
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-11-15 without embargo terms
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MIT/TFE FACTORS CONTROL ER-PHAGY VIA TRANSCRIPTIONAL REGULATION OF FAM134B
… reside in a poorly vascularized tissue, as the growth plate, with scarcity of nutrients, representing a good cellular model to study ER-phagy. We found that the nutrient responsive transcription factors TFEB and TFE3—master regulators of lysosomal biogenesis and autophagy—control ER-phagy by …
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Pct1 regulates phosphatidylcholine synthesis in response to changes in surface curvature elastic stress sensed on the inner nuclear membrane
… such as lipodystrophy with fatty liver, growth plate dysplasia and cone-rod related dystrophy. Numerous biochemical and structural studies on purified CCTα have revealed its membrane-bound activation and suggested that it acts as a lipid compositional sensor, yet the in vivo mechanism of …
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NG2/CSPG4 Regulates Alveolar Bone and PDL Microstructure in a Sex-Dependent Manner
… is expressed in mineralizing tissues such as growth plate cartilage and cranial sutures. However, its role in regulating alveolar bone density and organization remains unclear. The objective of this study was to define the role of NG2/CSPG4 in the growth and development of alveolar bone and …
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Expression and Function(s) of Parathyroid Hormone- Related Peptide in Intramembranous Bone Formation by Neonatal Rat Calvarial Cells In Vitro
… peptide is necessary for normal development and growth of the skeleton. The shortening of appendicular bones in knockout mice is explained by an effect of PTHrP on endochondral bone growth where it functions to inhibit the hypertrophy of chondrocytes in the epiphyseal growth plate. Whether or not …
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The effectiveness of different minimally invasive epiphysiodesis techniques in the management of paediatric leg length discrepancies: a systematic review
… curettage (PDC); physeal stapling; and guided growth with eight-Plates. Studies that evaluated two or more of the interventions or those that investigated a single intervention were considered for inclusion. Primary outcomes for the review included absolute LLD at skeletal maturity; rate of …