Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"Growth cone"”.
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Growth Cone Pathfinding and Neuromuscular Synaptogenesis in Drosophila Midline Mutants
… how abnormal midline decisions affect subsequent growth cone pathfinding. Results showed that despite abnormal decisions at the midline, subsequent pathways and synaptic targeting in all cases were the perfect mirror-images of those seen in wildtype. This suggests that a growth cones' particular …
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Repulsive cues and signalling cascades of the axon growth cone
… regarding the need for protein synthesis in the growth cone in response to external guidance cues. My results resolve the conflicting data in the literature on Semaphorin-3A signalling, where differing labs had shown that inhibiting protein synthesis either blocks or has no effect upon repulsion. …
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Regulation of the actin cytoskeleton in the neuronal growth cone
… diffusible and surface-bound guidance cues. The growth cone, a specialized structure found at the tips of axons and dendrites, detects and interprets these cues. Activation of downstream intracellular singling pathways leads to changes in the cytoskeleton of the growth cone that affect its …
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Analysis of Growth Cone Signaling During Axon Development in Drosophila Melanogaster
In addition, I demonstrated that growth cones expressing constitutively active Cdc42 that displayed guidance defects exhibited little change in their filopodial activity when compared to wild type, whereas others without guidance defects exhibited a significant increase. Moreover, the Y40C …
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Neuronal growth cone responses to extracellular guidance cues : an in vitro study
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1998.
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Identification, Characterization, and Developmental Analyses of A Growth Cone Specific Epitope and a Synaptic Vesicle Protein
<p>This thesis describes a growth cone specific epitope (CD'A 1), a synaptic vesicle antigen (SVP38), and the developmental expression of each in various tissues. Although CD'A 1 and SVP38 do not have any direct relationship to each other, I will show that the expression of both changes over the …
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Wnt Signaling in Growth Cone Mediated Neurite Outgrowth from Spiral Ganglion Neurons in the Adult Mouse
… implants is to stimulate and guide neurite outgrowth from spiral ganglion neurons toward electrodes to form private channels of communication between the cochlear implant and the targeted neuronal populations. To date, there has been little investigation into the roles of Wnt proteins signaling …
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Retinoic Acid and the Underlying Cellular Mechanisms involved in Neurite Outgrowth and Growth Cone Turning during Regeneration
… as well as tropic effects to guide neurite outgrowth. Cultured neurons of the Lymnaea central nervous system (CNS) have previously been used to investigate the role of RA in neurite outgrowth and growth cone guidance. Recently however, a novel phenomenon has been identified, in which neurite …
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Elucidation of the Retinoid Signalling Pathway Involved in Axon Guidance in Lymnaea stagnalis and Xenopus laevis
… has been shown to act as a guidance molecule for growth cones of regenerating motorneurons of the pond snail, Lymnaea stagnalis. Our lab has recently shown that RA can induce this morphological response independent of nuclear transcription, however, the role of the retinoid receptors in RA-induced …
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Investigating the Role of MicroRNAs in Regeneration and Axonal Pathfinding
… so, axons utilize a specialized structure, the growth cone, which senses and interprets guidance cues in its surrounding environment to change the direction of axonal outgrowth. MicroRNAs, which regulate mRNA translation, have recently been shown to regulate both neurite outgrowth and growth …
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Von der Form zur Richtung
Growth cones, the terminal structures of elongating neurites are important for development and regeneration. The second messenger cAMP regulates both processes. cAMP is also known to induce growth cone turning. By using time-lapse microscopy and release of cAMP from biological inactive caged …
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Repulsive axonal pathfinding requires the Ena/VASP family of actin regulatory proteins in vertebrates
… system to elaborate properly, the highly motile "growth cone" at the tip of an axon must sense extracellular embryonic cues and respond through a number of intracellular interactions leading ultimately to coordinated changes in cytoskeletal morphology and modulation of the axonal path. Here I …
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Quantitative analysis of axon elongation : a novel application of stochastic modeling techniques to long-term, high-resolution time-lapse microscopy of cortical axons
… developed a system for in vitro imaging of axon growth cones with time-lapse fluorescence microscopy. Image tiles are automatically captured and assembled into a mosaic image of a square millimeter region. GFP-expressing mouse cortical neurons can be imaged once every few minutes for up to weeks …
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Deciphering the biology of axon stretch-growth
… nerve regeneration strategies focus on growth cone-mediated growth, a form of nerve growth that occurs primarily during embryogenesis. Early axons continue to grow from the end distal to the soma, seeking targets on which to synapse. It is believed that once the axons synapse, …
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Fluorescence resonance energy transfer-based subcellular visualization of FAK/Src activation by chemical and mechanical environment
… neural circuits are maintained and rewired by growth cone dynamics, which are regulated by cytoskeleton reorganization and focal adhesion dynamics. Src and focal adhesion kinase (FAK) are key signaling molecules involved in these processes during growth cone dynamics and cell migration, and …
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Fabrication and evaluation of a collagen-based fiber-gel three-dimensional construct for peripheral nerve repair
… a peripheral nerve injury often relies on growth cone- mediated guidance and the presence of Schwann cells to support the regenerating axons and remyelinate portions of denervated nerve pathways. The emphasis of this work is to develop a synthetic nervous tissue construct that contains …
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Towards understanding the mechanisms behind mRNA localisation in growing axons
… mRNA density is four-fold enriched in the growth cone central domain compared to the axon shaft and that a modicum of directed transport is vital for delivery of mRNA to the axon tip. Through mathematical modelling it is further demonstrated that directional differences in motor-driven mRNA …
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Prenylation-independent activation of RhoA and Rac1: Effects on localization and neurite outgrowth
… switches that play a fundamental role in axon growth and guidance by directing growth cone cytoskeletal changes through interaction with downstream effectors. Small GTPases are considered active when bound to guanosine triphosphate (GTP), a process promoted by plasma membrane-associated guanine …
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Oncogenic Pathways and Molecular Prognostics in Neuroblastoma
… with good prognosis revealed genes involved in growth cone formation. Combination of the expressoin of growth cone associated genes with the snoRNPs resulted in a 4-gene prognostic signature. Calculating the ratio (R-score) between the expression of the good and bad prognostic genes removed the …
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Beach1 functionally antagonizes Rab11 during development and in regulating synaptic morphology
… in the photoreceptors drastically alters their growth cone morphology. In a subsequent genetic modifier screen, I identified rabll as a strong enhancer of the beach1 eye overexpression phenotype. Rabll is a small GTPase, which has been shown to regulate the delivery of vesicles and cargo to the …
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