Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 87 for “"Growth arrest"”.
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The growth-arrest-specific protein gas7 potentiates neuronal differentiation
The growth-arrest-specific gas7 protein is involved in neuronal development. Its role in neuronal differentiation and its potential neuroprotective activity were investigated in PC 12 and NT2 cells. gas7 overexpression in PC12 cells promoted neurite outgrowth and potentiated nerve growth …
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Analysis of senescence-like growth arrest induced by RUNX1 and its fusion derived oncoproteins
… from archetypal H-Ras [superscript v12] as arrest occurs without a preliminary phase of proliferation and the arrested cells lack prominent foci of DNA strand breaks and chromatin condensation. Notably however, RUNX1 and RUNX1-ETO display differences in their potency and the extent of …
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The Substituted Pyrrole JB-03-14 Induces Autophagic Cell Death and Growth Arrest in Breast Tumor Cells
… on tumor proliferation and survival, as well as growth arrest and cell death. Our findings indicate that the substituted pyrrole JG-03-14 induces time dependent cell death in breast tumor cells where the cell death involves apoptosis and autophagy. Residual growth arrest in p53 wild type cells is …
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Involvement of mitochondrial dysfunction during transforming growth factor β1-induced senescence-like growth arrest of MvlLu cells
… vulnerability to oxidative damage. Transforming growth factor β1 (TGF β1) has well been known to suppress epithelial cell growth and recently been described to be involved in cellular senescence. The purpose of this study is to investigate how TGF β1 could induce senescence in Mv1Lu mink lung …
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Increasing IFN-[gamma] productivity in CHO cells through CDK inhibition
… of research for many decades. The induction of growth arrest is one such area that shows particular promise. Through the use of siRNA and chemical cyclin dependent kinase (CDK) inhibitors, we have developed new methods to improve and better understand recombinant protein production during growth …
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Active hypothermic growth : a novel means for increasing total recombinant protein production by CHO cells
… cells under mild hypothermia (30-33 ⁰C) leads to growth arrest in the G₀/G₁ phase of the cell cycle and, in some cases, causes an increase in specific productivity of recombinant protein, as was shown here for the model CHO cell line producing human interferon-gamma (IFN-[gamma]). Controlled …
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Accessory Nucleases Provide Robust Antiparasite Immunity for Type III CRISPR-Cas Systems
… invader transcripts. This induces a transient growth arrest in the host cell, which is relieved upon target clearance. This growth arrest "buys time" for the Cas10-Csm complex to eliminate the plasmid, which is required for clearance against weakly transcribed targets. Further, I expand and …
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Understanding the Effect Of 1,3-Butadiene on Human Lung Fibroblasts: Does Exposure to 1,3-Butadiene Induce Senescence?
Cellular senescence is a state of irreversible growth arrest induced by either telomere shortening (replicative senescence) or telomere-independent signals (stress-induced premature senescence or SIPS). Recent studies have shown that cigarette smoke extract induces senescence in lung fibroblasts …
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The Role of Glutathione Synthetase in Trypanothione Biosynthesis in Trypanosoma brucei
… pathways, and assess if it is essential for growth. To determine whether the putative TbGS gene was correctly identified through sequence homology, I cloned and expressed the T. brucei gene (TbGS) in Escherichia coli, and purified the recombinant protein. Using an ATP-coupled …
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Role of MDM2 In Cell Growth Regulation
MDM2 has been shown to induce G0-Gl/S phase arrest. To determine the cell cycle step targeted by MDM2, flow cytometry was employed to detect induction of events during the G1-S phase transition in MDM2-arrested cells. MDM2 overexpression does not prevent expression of cyclin D, cyclin D-CDK …
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Influence of the Vitamin D3 Analog EB 1089 on Senescence and Cell Death Pathways in the Response of Breast Tumor Cells to Ionizing Radiation
A senescence-like growth arrest succeeded by rapid recovery of proliferative capacity is observed in MCF-7 breast tumor cells exposed to fractionated radiation (5 x 2Gy) alone. Exposure to the vitamin D3 analog EB 1089 (100nM) prior to irradiation converts the initial growth arrest response to cell …
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The inhibition of mammary epithelial cell growth by the long isoform of Angiomotin
Mammary ductal epithelial cell growth is controlled by microenvironmental signals in serum under both normal physiological settings and during breast cancer progression. Importantly, the effects of several of these microenvironmental signals are mediated by the activities of the tumor suppressor …
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Telomere Position Effect in Human Cells
… shortened telomeres trigger a state of growth arrest termed replicative senescence.
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Orthopaedic implications of physeal arrest following meningococcal septicaemia
… were directed at the treatment of sequelae of growth arrest alone and excluded amputations, contracture releases, skin grafts and flaps. The extent of the surgical problems caused by this disease brought about the realisation that a thorough review of the literature and follow up of these …
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Effectiveness of surgical versus conservative treatment for distal femoral growth plate fractures: a systematic review
Injury to the distal femoral growth plate in children is typically due to a high-energy trauma such as contact sports or motor vehicle accidents. There is no clear evidence as to whether surgery or application of a plaster or splint is the best option for these injuries in terms of growth arrest …
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Analysis of the Transcriptional Regulation and Bidirectional Nature Of the Promoter of the p53 Tumor Suppressor Gene
… response and/or failure to undergo cell cycle arrest in response to cellular stress or DNA damage. Understanding the transcriptional regulation of the p53 gene can contribute to our understanding of the mechanisms involved in regulating the overall levels of p53 protein. We have identified two …
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Functional Analysis of the Human Telomeric Protein TRF2
… cells resulted in induction of senescence. The arrested cells exhibited elevated levels of p53, stabilization of was accompanied by induction of its downstream effectors p21 and Bax. The Rb pathway was also affected, with pRb becoming hypophosphorylated. The importance of both the p53 and the Rb …
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Role of Abberant Proteolysis in the Pathogenesis of APL
… how N-CoR misfolding supports the survival and growth of APL cells, and to screen potential therapeutic agents that could induce growth arrest through targeting the misfolded N-CoR-induced survival pathways in APL.
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Negative Regulation of the Hippo Pathway by the Ajuba LIM Proteins
… of the YAP/TAZ transcriptional coactivators and growth arrest. Previous work from our lab has identified the Ajuba LIM proteins as novel negative regulators of the Hippo pathway in both Drosophila and mammals. However, the mechanism by which the Ajuba LIM proteins prevent Hippo pathway activity …
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