Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 555 for “"Growth Factors"”.
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Insulin -Like Growth Factors Regulate Cardiac Hypertrophy
… by the local production of IGF-II, that this growth factor then stimulates the hypertrophy via an IGF-I receptor-independent, IGF-II-responsive pathway that likely involves the IGF-II receptor.
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Expression of angiogenic growth factors in laryngeal carcinoma
… blood vessels (angiogenesis) is vital for the growth and metastasis of solid tumours, with the expression of key angiogenesis-related proteins having been shown to have prognostic significance. This study aims to identify key proteins within the tumour microenvironment, which may be involved in …
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Influence of Growth Factors on Bovine Embryo Development
… species (ROS). Similarly, beneficial effects of growth factors for improving the rate of blastocyst development have been reported, but combined effects are unknown. This study was conducted to determine the additive effect of the antioxidant cysteine with epidermal growth factor (EGF) and/or …
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Growth factors in extraocular muscles: effects on contractile properties
… dissertation, I examined the effects of three growth factors, IGF1 (Insulin-like Growth Factor 1), CT1 (Cardiotrophin 1), and GDNF (Glial-cell line derived neurotrophic factor), on contractile properties of extraocular muscles, and I provide evidence that these growth factors regulate …
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Proto-oncogene Regulation by Growth Factors in Bone Cells
… that bone cells in culture produce a number of growth factors that are important in bone regulation. Chick and mouse primary calvarial cultures consist of a mixture of cell types that make it difficult to interpret the results from these model systems. In contrast, MC3T3-E1 cells are a clonal …
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The role of insulin-like growth factors in the fetus
… supply is important in the regulation of fetal growth. The insulin-like growth factors (IGFs), insulin and placental lactogen (PL) may be important mediators in fetal growth regulation. However, nutritional regulation of circulating concentrations of IGFs, their binding proteins (IGFBPs) and PL …
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Stimulating angiogenesis into biomaterials through the delivery of growth factors
… material into the host tissue, transmural ingrowth of tissue and vasa vasorum might have to be facilitated. Since VEGF1ss and PDGF-BB are growth factors known to stimulate and consolidate angiogenesis, this PhD thesis hypothesized, that neovascularisation of porous polyurethane (PU) can be …
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The role of growth factors in the regeneration of skeletal muscle
… myostatin and components of the insulin-like growth factor (IGF) axis during regeneration, to determine whether these factors were temporally regulated during regeneration, whether the absence or presence of growth hormone (GH) affected their levels, and lastly, whether the administration of …
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DIFFERENTIAL EFFECTS OF GROWTH FACTORS ON GLYCOLYSIS IN OVARIAN CANCER CELLS
… receptors. It has been known as an oncogenic growth factor in ovarian cancer and other types of human malignancies. However, the precise biological functions of LPA in ovarian oncogenesis remain to be fully elucidated. Our laboratory is interested in studying the potential role of LPA, as a …
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The role of natural equine growth factors in experimental bone engineering.
Contains fulltext : 76501.pdf (Publisher’s version ) (Open Access)
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Local pharmacokinetics and pharmacodynamics of angiogenic growth factors in myocardial tissue
… regeneration to treat ischemic tissue with growth factors, has been tempered by a series of unsuccessful clinical trials with limited late efficacy and a wide range of mixed results. This thesis was designed to examine critically whether the lack of late efficacy of local delivery of …
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Effects of cellular and tissue pharmacokinetics on control released growth factors
… and tissue pharmacokinetics on control released growth factors. Motivation: The resurgence of interest in controlled drug delivery reflects the increasing appreciation of the importance of local pharmacokinetics in defining the efficacy and potency of bioactive compounds. Despite promising data …
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Transport and binding of insulin-like growth factors to articular cartilage
Thesis (S.B. and M.Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1999.
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Relationship between senior pastors' attitudes toward organizational change and church growth factors
… of organizational change and various church factors. The study consisted of 138 senior pastors who completed a self-report inventory assessing their attitude toward organizational change. The results were then utilized along with additional reported data concerning ministry tenure, church …
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Growth Factors Up-Regulate Epithelial Stem Cells: Treatment Strategies for Colorectal Cancers
… in chapter 2, conclude that ANXA2 mediates growth effects of PG on target cells (including colonic-epithelial-cells), in vitro and in vivo, associated with up-regulation of stem/progenitor cell markers. Surprisingly, overexpression of autocrine PG in HEK-293 cells, imparted …
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The role of heparin and heparin-binding growth factors in pre-eclampsia
… hypothesis that expression of heparin-binding growth factors (HBGFs) in normal placental development was altered in a specific pregnancy disorder preeclampsia. HBGFs bind to heparin, a glycosaminoglycan (GAG) affecting activity. I investigated the role of heparin and HBGFs in pathophysiology of …
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Regulation of mTOR complex 1 in response to growth factors and nutrients
… cells ensure the simultaneous availability of growth factors and nutrients before they invest in cellular processes that lead to growth. The TOR kinase is a master regulator of cellular growth and nucleates two distinct protein complexes known as TOR complex 1 and 2 (TORC1 and 2). The activity …
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Role of autocrine growth factors in the tumorigenic transformation of T cells
… may result from aberrant regulation of autocrine growth factor production. We describe for the first time characterization of several normal T cell lines that underwent spontaneous transformation resulting from constitutive expression of interleukin-2 (IL-2) and interleukin 2 receptor (IL-2R) …
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