Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 50 for “"Growth Factor Receptors"”.
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Signaling mechanisms and developmental function of fibroblast growth factor receptors in zebrafish
Fibroblast growth factor (Fgf) signaling plays multiple inductive roles during development of vertebrates (Itoh 2007). Some Fgfs, such as Fgf8, are locally secreted and signal over a long range to provide positional information in the target tissue (Scholpp and Brand 2004). Fgf ligands signal in a …
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Regulation of Cardiac Fibroblast and Coronary Vascular Smooth Muscle Development by Platelet Derived Growth Factor Receptors
… with epicardial specific deletions of the PDGF receptors, I discovered that these receptors control EPDC fate and epicardial EMT. I demonstrated that each receptor was required for development of a unique epicardial derivative, PDGFRα for cardiac fibroblasts and PDGFRβ for cVSMC. I also found …
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The role of cellular growth factor receptors in mediating gene transfer by adeno-associated virus 2 vectors
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Design, Synthesis and Biological Evaluation of Novel Estradiol-Triazole Analogs Targeting Epidermal Growth Factor Receptors in Colorectal Cancer
… Among these molecular targets is Epidermal Growth Factor Receptors (EGFRs) which are overexpressed in cancer cells. Targeting and blocking the downstream signaling could lead to cease cell proliferation and division and hence control the spread of the disease. Molecular modeling is a …
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The Role of Tyrosine Kinase Growth Factor Receptors in Psoriatic Epidermal Hyperplasia: Analysis of Growth Factor Synergy in Cultured Human Keratinocytes and Receptor Expression in Psoriatic Skin
… phenotypic changes in the disease. The epidermal growth factor (EGF) receptor pathway is an important mediator of keratinocyte growth and both ligand and receptorcomponents of this pathway are abnormally expressed in hyperproliferative epidermis. In contrast, little is known about the function of …
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Sunitinib-Induced Cardiotoxicity Exposes Microvascular and Metabolic Derangements In The Failing Heart
… patients have significant cardiovascular risk factors at the time of diagnosis, but a number of targeted therapies can themselves cause cardiac dysfunction. These newer treatment options are also increasingly effective, placing a growing emphasis on post-cancer quality of life. In some …
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Gsk3 Mediates Signaling Upstream of Akt
… cellular functions. PI3K links the extracellular growth factor receptors to the serine-threonine kinase Akt which, through phosphorylation of numerous intracellular proteins, mediates increased cell growth, survival, motility and proliferation. The significance of the PI3K/Akt signaling network to …
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Interleukin-10 Induces Apoptosis in Developing Mast Cells via a Mitochondrial, STAT3-dependent Pathway
… significant alterations in the mast cell growth factor receptors IL-3R and c-kit. The loss of these growth factor receptors may explain the apoptosis induced by IL-10. These data demonstrate the potent regulatory capabilities of Th2 cytokines on mast cells, a central effector in the Th2 …
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Canine Mast Cell Tumours: Characterization of Subcutaneous Tumours and Receptor Tyrosine Kinase Profiling
… MCT. Based on evidence that vascular endothelial growth factor receptors (VEGFR) and platelet-derived growth factor receptors (PDGFR) - may play a role in the progression of canine MCT; the expression and distribution of these RTK were evaluated. The results showed that canine MCT have unique …
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Multiplexed angiogenic biomarker quantification on single cells
… Recently, quantification of vascular endothelial growth factor receptors (VEGFRs) provided important insights into endothelial cell (EC) characteristics and response in tumor microenvironments. However, data on other angiogenic receptors, such as platelet derived growth factor receptors (PDGFRs), …
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Characterization of XV7 and XV9 cDNA clones which confer osmotolerance to Eschericia coli
… are structurally related to the polypeptide growth factor receptors of animals (Walker, 1994). Although several ABA and stressresponsive gene have been characterised, their physiological role in the initial perception and transduction of stress signals is not well defined Recent reports …
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Bridging molecular and systems scales in membrane biology
… such as hERG (Chapter 5), and the ability of growth factors to bind and activate growth factor receptors, such as VEGFR-2 (Chapter 6). The last chapter showcases the application of different computational methods, which integrates molecular simulation and metabolic modeling in the development …
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Expression and Purification of Unlabelled and Isotopically Labelled Human Fibroblast Growth Factor-1 and its Receptor Relevance in Cancer Research
<p>Studies show that fibroblast growth factors (FGFs) control variety of cellular activities such as mitosis, cell differentiation, survival and angiogenesis. The FGF family consists of 23 different heparin-binding proteins. One of the most intensively studied members is human FGF-1 (hFGF-1) …
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Regulation of FGF Receptor signalling by SPROUTY and SPRED
Signalling from Fibroblast Growth Factor Receptors (FGFRs) is under tight control by a wide variety of extrinsic and intrinsic regulatory mechanisms, many of which remain poorly defined. Sproutys and their related Spred proteins constitute two such families of signalling regulators with multiple …
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Chemomechanics at the cell-material interface : measurements and implications of forced molecular unbinding
… responses of cells or mapping of cell surface receptors is mediated by chemomechanically characterized AFM cantilevers. The high spatial and force resolution of AFM imaging techniques and force spectroscopy enabled investigation of mechanical interaction at the cell-cell or cell-material …
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PDGFRalpha Signaling Requirements in the Development of Tissues Derived From Sclerotome and Dermatome
The Platelet-Derived Growth Factor Receptors (PDGFR) play roles in the development of multiple mesenchymal cell types. Upon ligand binding, the receptors signal through a number of intracellular signaling molecules and elicit many cellular responses including migration, proliferation, and …
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Molekulare Genomanalysen des invasiven Mammakarzinoms und Untersuchung des Einflusses chromosomaler Imbalancen auf die Genexpression
… correlated neither with extent of tumour growth, grade or differentiation. Analysis of intratumoral heterogeneity showed that in well advanced tumours, the karyotype of a single cell clone was mostly representative for the entire tumour cell population. Statistically, common intra- and …
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Impact of delta-tocotrienol on human melanoma cell proliferation
… for the prenylation or dolichylation of growth-related proteins including nuclear Ras, nuclear lamins, and growth factor receptors. d-δ-tocotrienol, a post-transcriptional down-regulator of HMG CoA reductase, suppresses the proliferation of marine B16 melanoma cells and human blood, …
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Identification of novel components in fibroblast growth factor signalling
Fibroblast growth factor receptors play many roles in development, cell proliferation and differentiation. They possess intrinsic tyrosine kinase activity which enables activation of other signalling proteins, formation of multiprotein signalling complexes and activation of downstream cascades. The …
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Investigating the Biological Functions of the Protein Kinase WNK1 in the Regulation of Cytoskeletal Structures and Membrane Trafficking
… of WNK1 caused higher amount of epidermal growth factor receptors remained at the later step of endocytosis. Lysosomes and lysosome-related organelles were disrupted. Biochemical assay suggested that WNK1 could associate with active Rab 6 or 7 effector complexes. I have identified that the …
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