Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"Growth Factor Delivery"”.
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Polyelectrolyte multilayer growth factor delivery : mediating tissue/device interactions
… on the use of ultrathin therapeutic protein delivery films to control host tissue/medical device implant interactions, thereby reducing complications that lead to implant failure. The Layer by Layer (LbL) deposition platform was used to fabricate conformal, tunable, micron scale reservoirs …
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Pharmacokinetics of local growth factor delivery in myocardial tissue
… angiogenesis by means of the locally delivering growth factors to the myocardium. When deposited within heart tissue the compounds elicit a vascular response that is hoped to perfuse ischemic myocardium. There is, however, little quantitative data on macromolecular transport in myocardium, their …
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Affinity-based Growth Factor Delivery from Injectable Hydrogels for Tissue Engineering
… strategies have been impaired by both poor delivery of therapeutic agents to the site of injury and a lack of sustained release that is required for long-term efficacy. In this thesis, a strategy for delivering protein therapeutics in a localized and sustained fashion is presented within the …
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Stimulation of angiogenesis through growth factor delivery from synthetic heparinised hydrogels
… and controlled release of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), as well as their bioactivity and angiogenic potential in vivo. Methodology: VEGF and bFGF were combined into 4% (m/v) PEG-Hep hydrogels. The binding and release rates of VEGF and BFGF …
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Polysaccharide-based nanostructures for growth factor delivery and mesenchymal stem cell activation
… polysaccharide-based nanostructures for growth factor delivery and MSCs activation. Different polysaccharide-based nanostructures were developed and characterized including polyelectrolyte multilayers (PEMs) and electrospun nanofibers. On flat gold-coated glass surfaces, PEMs were …
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Controlled growth factor delivery from biodegradable hydrogel scaffolds for articular cartilage repair
… glycol) fumarate) (OPF) hydrogels as carriers of growth factors for articular cartilage repair has been investigated. In vitro release studies examined release of transforming growth factor-beta1 (TGF-beta1) directly from OPF hydrogels and also from gelatin microparticles encapsulated within these …
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Modified polyethylene glycol hydrogels for growth factor delivery and controlled tissue invasion
… A promising alternative approach is the cardiac delivery of potentially cardioprotective and regenerative growth factors from biomaterial scaffolds. One hydrogel system that has promise in this area is an injectable enzymatically degradable polyethylene glycol (PEG) hydrogel. Two modifications …
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Growth Factor Delivery From Fibrin Matrics Containing Affinity-Based Delivery Systems To Treat Peripheral Nerve Injury
… to further the understanding of affinity-based delivery and to serve as a potential treatment for peripheral nerve injury. The use of an affinity-based delivery system: ABDS) with growth factors in a nerve guidance conduit: NGC) was hypothesized to promote nerve regeneration and functional …
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In vitro and in vivo growth factor delivery to chondrocytes and bone-marrow-derived stromal cells in cartilage and in self-assembling peptide scaffolds
… this work was to develop methods for delivering growth factors to cartilage and to test the ability of a self-assembling peptide scaffold, (KLDL)3, with or without growth factors to augment repair. Delivery methods included growth factor adsorption, scaffold-tethering, and modification of growth …
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Self-assembling peptide hydrogels promote in vitro chondrogenesis of bone marrow-derived stromal cells : effects of peptide sequence, cell donor age, and method of growth factor delivery
… peptide hydrogels, modified for controlled delivery of pro-chondrogenic factors, generate cartilage-like neotissue and are compatible with a single-surgery, autologous therapy for cartilage repair.
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Investigations into the stability of growth factor induced-vasculature and the effects of synthetic biomaterials on heart remodelling after myocardial infarction
… was based on the hypothesis that optimization of growth factor delivery rate and duration, combined with a biomaterial scaffold, could lead to an improved strategy for therapeutic neovascularization. To test this hypothesis, a novel in vivo model system that allows for characterization of …
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Functionalised self-assembled peptide hydrogel for cell transplantation
… a multifaceted anti-inflammatory hydrogel delivery system by the co-assembly of the anti-inflammatory macromolecule, fucoidan, into SAPs. Using this system, we have demonstrated the attenuation of the size of primary glial scar to half that of a stab injury(control), with increased …
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Functionalised self-assembled peptide hydrogel for cell transplantation
… a multifaceted anti-inflammatory hydrogel delivery system by the co-assembly of the anti-inflammatory macromolecule, fucoidan, into SAPs. Using this system, we have demonstrated the attenuation of the size of primary glial scar to half that of a stab injury(control), with increased …
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Stimulating angiogenesis into biomaterials through the delivery of growth factors
… material into the host tissue, transmural ingrowth of tissue and vasa vasorum might have to be facilitated. Since VEGF1ss and PDGF-BB are growth factors known to stimulate and consolidate angiogenesis, this PhD thesis hypothesized, that neovascularisation of porous polyurethane (PU) can be …
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Local pharmacokinetics and pharmacodynamics of angiogenic growth factors in myocardial tissue
… regeneration to treat ischemic tissue with growth factors, has been tempered by a series of unsuccessful clinical trials with limited late efficacy and a wide range of mixed results. This thesis was designed to examine critically whether the lack of late efficacy of local delivery of …
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Mechanical influence of pressure, topography, and diffusion on cell physiology and function
… is introduced. This stamp delivers blood vessel growth factors, via diffusion, to the target tissue in order to guide blood vessel formation in the same pattern as inscribed in the stamp. To explore the mechanics behind the diffusional growth factor delivery, a finite element model was created to …
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Development of Delivery Strategy for Adipose-Derived Stem Cells in the Treatment of Myocardial Infarction
… disease. However, previous studies involving the delivery of ASCs following MI have indicated that therapeutic efficacy has been limited by low survival and/or poor retention of the transplanted cells at the site of injury. To address these limitations, the goal of this thesis was to develop a …
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Development and Characterization of Photocrosslinkable Hyaluronic Acid Hydrogels for Cartilage Regeneration
… development to improve cartilage regeneration, growth factor delivery optimization and successful implementation of these hydrogels in cartilage defect models remain, towards our goal of a successful long-term repair solution to cartilage damage.
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Layer-by-Layer Systems for Craniomaxillofacial Bone Repair
… increasingly recognized that release rate of growth factor proteins signaling bone regeneration and vascularization is a key optimization parameter since these proteins are rapidly cleared from the body and can have safety ramifications when released too rapidly. A clear delivery challenge …
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