Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"Group A streptococci"”.
-
An Epidemiological Evaluation of Antagonism Between the Normal Throat Flora and Group a Streptococci
The epidemiology, treatment, and prevention of group A streptococcal pharyngitis and its sequela of rheumatic fever have been extensively studied. Estimates of the incidence of streptococcal pharyngitis in the United States have ranged from 400,000 to 7 million cases annually. Case rates are …
-
The Dynamic Streptococcus Pyogenes Transcriptome in the Host Cell Environment and Contributions by Phage
… interested in global regulatory systems in group A streptococci and how they impact virulence regulation. With this work, we hoped to identify new regulatory elements involved in the infection process. The first objective of this thesis was to determine the transcriptional shift induced in …
-
The Role of Lysogenic Bacteriophage in Virulence and Survival of Streptococcus Pyogenes
… of certain erythromycin-resistant isolates of group A streptococci are resistant to SmaI endonuclease cleavage. In the work presented here, we identified a restriction modification system contained on the bacteriophage chimeric-element and successfully characterized the first methyltransferase …
-
Bacterial Outer Membrane Vesicles. Mediators of virulence and antibiotic resistance.
… studies have shown treatment failures of group A streptococci (GAS) in pharyngotonsillits even though the GAS are completely susceptible to β-lactams, and that NTHi and M. catarrhalis are often found associated with GAS during treatment failures. We found that OMV from β-lactamase positive …
-
Studies of the pathogenesis of IgA nephropathy and Henoch-Schönlein purpura, with special reference to Streptococcus pyogenes infections and complement
… the respiratory tract and often caused by group A streptococci (GAS). GAS express the surface bound M protein, which varies in sequence between strains and in certain serotypes includes an IgA-binding region (IgA-BR). The complement system, an important part of the innate immune system, is …
-
Recurrent Streptococcal Pharyngotonsillitis Studies on etiology and treatment
In acute pharyngotonsillitis group A streptococci (GAS) is the etiological agent in 30-50% of cases. Phenoxymethylpenicillin (pcV) is the drug of choice in Sweden. However, the failure rate is as high as 5-25% and further pcV treatment is followed by still higher failure rates. The background of …
-
Immune Blocking of Fluorescent Antibody Staining of Streptococcus Group A Compared with Anti-streptolysin O
… test in the detection of Streptococcus pyogenes group A antibodies in sera samples.</p> <p>A slide inhibition test was used to detect the presence of FABA in the following manner; (a) fix group A streptococcal cells to a slide, (b) incubate these cells with the patient's serum for thirty minutes, …
-
Studies of a Novel Phage Lytic Enzyme, PlySs2
… aureus (MRSA) and Streptococcus pyogenes (group A streptococci – GrAS) cause potentially fatal human diseases. These are just three of the many Gram-positive pathogens for which resistance to leading antibiotics has emerged. The goal of this work was to develop a novel antimicrobial …
-
Virulence gene expression of three hypervirulent S. pyogenes M1T1 and membrane vesicles isolation
… chains and are usually facultatively anaerobic. Streptococci are a diverse collection of species inhabiting many body sites and they are both commensals and pathogens. In particular, nonpathogenic streptococci, are the most abundant bacterial species at the oropharyngeal level, and they have been …
-
Role of the lactoferrin-binding protein in pathogenesis of streptococcus uberis
… sequence homology of Lbp to Mrelated proteins of Group A streptococci suggested a possible functional similarity between Lbp and M-like proteins, which are involved in evasion of host antibacterial defenses, adhesion to host epithelial cells and intracellular invasion by the bacteria. …
-
Biochemical and Immunological Mechanisms Underlying Differential Interaction of Superantigens with Host Immunogenetic Factors in Streptococcal Sepsis
<p>Group A streptococci (GAS) are serious human pathogens that can cause a wide array of diseases ranging from pharyngitis to streptococcal toxic shock (STSS), which is caused by excessive cytokines responses triggered by streptococcal superantigens (Strep SAgs). SAgs interact simultaneously with …
-
Mode of Action of Penicillin in Pneumococci: From Inhibition of Cellular Targets to Bacterial Death
… mutants with inactivated amidase (lytA) gene and group A streptococci), suggesting that mechanisms other than bacterial autolysis may exist for the cidal effect of this antibiotic. We have investigated the existence of such autolysis-independent lethality in pneumococci. The results of these …