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Showing 1 to 20 of 24 for “"Group A Streptococcus"”.
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Genomic insights into Group A Streptococcus pathogenesis
Group A Streptococcus (GAS) is a bacterium responsible for invasive and non-invasive infections in humans. The sequela of an untreated or undertreated GAS pharyngitis include Rheumatic Fever (RF) and Rheumatic Heart Disease (RHD). Despite evidence for the effectiveness of antibiotics such as …
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Potential Approaches to Limiting Group A Streptococcus Virulence
Group A Streptococcus (GAS) is an obligate human pathogen capable of causing a wide array of diseases ranging in both severity and site of infection. The current forms of treatment are limited, consisting of antibiotic regimens and in severe cases surgical debridement to remove infected tissue. …
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Functional Domains in the Multigene Regulator of the Group A Streptococcus
The group A streptococcus (GAS) is a human pathogen capable of causing a broad range of symptoms from mild erythema to severe tissue destruction. The multigene regulator of the GAS, or Mga, has been shown to bind DNA and activate transcription of virulence genes implicated in colonization and …
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Comprehensive Investigation into the Molecular Mechanisms Driving the Emergence of emm4 Group A Streptococcus
… Driving the Emergence of <em>emm4</em> Group A <em>Streptococcus</em></strong></p> <p>Chioma Modeline Odo, M.S.</p> <p>Advisory Professor: Samuel A. Shelburne, MD, Ph.D.</p> <p>The major gram-positive bacterium group A <em>Streptococcus</em> (GAS) is a model organism for studying …
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The molecular characterisation of Group A Streptococcus among children with phyryngitis in the Vanguard community (Bonteheuwel
Includes abstract. Includes bibliographical references.
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The streptococcal collagen-like protein-1 (Scl1) is a multifunctional adhesin in extracellular matrix interactions, biofilm formation, and host colonization by group A Streptococcus
Group A Streptococcus (GAS) is responsible for over 100 million skin infections annually that may lead to invasive episodes and autoimmune sequelaes. Wounds and unapparent skin infringements are susceptible to the introduction of GAS and serve as a portal of entry. The nutritional nature of a wound …
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SRV REGULATION OF STREPTOCOCCAL BIOFILM DISPERSAL AND ITS IMPACT ON VIRULENCE
Group A Streptococcus (GAS) is a Gram-positive human pathogen that commonly causes mild skin infections. However, GAS also causes severe infections including necrotizing fasciitis. The mechanism for triggering the switch between mild and severe disease has yet to be discovered. Several groups have …
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Turning Tears into Sweets: CandyCollect for Pediatric Salivary Pathogen Sampling
… capture commensal salivary bacteria, including Streptococcus mutans and Staphylococcus aureus, from healthy adults. Chapter 4 presents the first clinical data using CandyCollect devices to sample pediatric patients diagnosed with Group A Streptococcus (GAS) pharyngitis. In summary, this …
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Phenotypic and Genotypic Models of Streptococcal Colonization of the Human Tonsil
… due to oropharyngeal infection with Streptococcus pyogenes is most commonly treated by using penicillin-derived antibiotics.While treatment failure in the 1950's was reported in 4-8% of children, more recent studies have alarmingly found antibiotic failure as high as 20-40% providing …
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Antibacterial peptides - key players in host defense at epithelial surfaces
… are important to prevent bacterial invasion. Streptococcus pyogenes, group A streptococcus (GAS), has an affinity for epithelial cells and cause pharyngitis. During streptococcal pharyngitis, high concentrations of the chemokines CXCL9/MIG, CXCL10/IP-10, CXCL11/I-TAC were found in tonsil …
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The prevalence of Group A Beta-Hemolytic Streptococci carriage in children in Africa: a systematic review
… children can be a major reservoir of pharyngeal Group A Streptococcus (GAS) with reported figures ranging from <10% to >20% in developing countries. There is a need to document GAS carriage in school children, which, together with the molecular characterisation (M-typing) of strains harboured in …
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Virulence gene expression of three hypervirulent S. pyogenes M1T1 and membrane vesicles isolation
… infections. In this regard, a key species is Streptococcus salivarius, a lactic acid bacterium that is mainly encountered in the mouths of human beings. It is the first commensal bacterium that appears in the oral cavity of newborns where it colonizes the upper respiratory tract [Aas JA et …
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The generation and maintenance of T Helper 17 cells in response to bacterial infection
… of immunity to the extracellular bacterium Group A Streptococcus pyogenes (GAS) and the intracellular bacterium Listeria monocytogenes (LM), along with a sensitive peptide:Major Histocompatibility Complex II (pMHCII) tetramer and magnetic bead-based enrichment method to study the …
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A study of determinants and prevalence of Rheumatic Heart Disease in Cape Town
… an interaction between a rheumatogenic strain of group A streptococcus, a susceptible host who lives in poor social conditions with limited access to medical facilities. The disease process begins with repeated group A streptococcal (GAS) infections, which, subsequently result in acute rheumatic …
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Identification of surface protein complexes of Streptococcus pyogenes through protein microarray technology
… In this study approximately 100 proteins of Group A Streptococcus (GAS) predicted to be secreted or surface exposed by genomic and proteomic approaches were purified in a His-tagged form and used to generate protein microarrays on nitrocellulose-coated slides. To identify protein-protein …
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Use of an Animal Model of Group A Streptococcal Infection to Identify Factors Important for Virulence
The Group A Streptococcus (GAS) is a strict human pathogen responsible for a broad assortment of diseases ranging from pharyngitis (strep throat) and impetigo to necrotizing fasciitis (flesh eating disease) and streptococcal toxic shock syndrome (STSS). Virulence of the GAS is multifactorial, as it …
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CcpA-Mediated Carbon Catabolite Repression of Virulence in the Group A Streptoccus
The group A streptococcus (GAS) is a strict human pathogen, which causes a broad spectrum of diseases ranging from the self-limiting diseases such as pharyngitis and impetigo to the more severe invasive disease such as necrotizing fasciitis. The coordinate expression of a wide array of virulence …
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Effects of low molecular weight compounds on growth, virulence gene expression and cytotoxic activity of Shiga toxin-producing Escherichia coli O157:H7
… down-regulation of virulence gene expression in group A Streptococcus and Staphylococcus aureus by this novel class of low molecular weight compounds, prompted the theory that their analogs may cause similar effects with STEC virulence genes. Recent preliminary experiments have generated quite …
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Functional and Structural Characterisation of Spy0136, a Novel Group A Streptococcal Virulence Factor
Streptococcus pyogenes (Group A Streptococcus, GAS) is a leading human pathogen associated with a broad range of diseases and over half a million deaths annually all over the world. GAS generates numerous virulence factors contributing to the bacteria's pathogenesis. However, the function of many …
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