Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Gross chromosomal rearrangements"”.
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Effect of Werner and Bloom Helicase Deficiencies On Dna Double-Strand Break Repair
… However, many of the clones experienced gross chromosomal rearrangements. BLM-null cells were found to repair DSBs mainly by HR, with many clones yielding crossover events. These abnormalities in DSB repair suggest that both WRN and BLM do have specific roles in DSB repair.</p>
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The Molecular Mechanism of Break Induced Replication
… of collapsed replication forks and several chromosomal instabilities. Recently, our lab demonstrated that the fidelity of DNA synthesis associated with BIR in yeast Saccharomyces Cerevisiae is extremely low. The level of frameshift mutations associated with BIR is 1000-fold higher as …
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ADVANCED AAV-MEDIATED LIVER-DIRECTED GENE THERAPIES FOR HAEMOPHILIA A AND MUCOPOLYSACCHARIDOSIS TYPE VI
… Moreover, in AAV-HITI treated livers nor gross chromosomal rearrangements or significant off-target insertions/deletions were observed 1-year post neonatal delivery. Furthermore, I demonstrated the effectiveness of this platorm in adult MPS VI and HemA mice, using vector doses that are …
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Mechanisms of Palindrome-Mediated Chromosomal Instability
… are highly unstable DNA sequences that induce chromosomal rearrangements and underlie cancer and hereditary diseases such as Emanuel Syndrome. Despite being a significant source of genomic instability, the mechanisms governing palindrome fragility in eukaryotic cells are not fully defined. In …