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Showing 1 to 14 of 14 for “"Griseofulvin"”.
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The Mode of Action of The Antibiotic Griseofulvin
Made available in DSpace on 2014-12-09T18:06:24Z (GMT). No. of bitstreams: 1 6604202.pdf: 3351324 bytes, checksum: c827c49bce6885e5f4c6ae0044b42aba (MD5) Previous issue date: 1965
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Preparation and characterization of fast dissolving pullulan films containing griseofulvin nanoparticles for bioavailability enhancement
… this study is to enhance the bioavailability of griseofulvin, a model poorly water-soluble drug, via increasing drug dissolution rate through preparation of drug nanoparticle-laden, pullulan-based strip films. The work entails (i) wet-milling griseofulvin in a stirred media mill using pullulan …
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The use of novel poly(allylamine) based amphiphilic polymers for drug delivery.
… model hydrophobic drugs, propofol, prednisolone griseofulvin, etoposide and novel anticancer agent BNIPDaoct. The Ch5 and Dansyl10 showed excellent drug solubilisation capacities. At 6 mgmL-1 the Ch5 achieved propofol solubility 70-fold greater than its aqueous solubility, prednisolone, …
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Application of raman spectroscopy in pharmaceuticals
… powders, and the melt-grown amorphous phase of griseofulvin, a model active pharmaceutical ingredient (API), is presented and discussed in detail. A key feature was the observation of a broad inelastic background superimposed on the Raman spectra of cryomilled powders, which is attributed to …
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Precipitation of ultrafine particles using liquid antisolvent with concentric ultrasonic nozzle and subcritical CO2
… work focuses on micronization of class ii drug Griseofulvin which is poorly water soluble. Two processes namely, liquid antisolvent precipitation using ultrasonic nozzle and other process using subcritical CO_2 have been used to produce ultrafine particles of this drug. In liquid antisolvent …
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Effect of Compression Force on Agglomeration of Micronized Active Pharmaceutical Ingredients: Techniques to Prevent API Agglomeration During Compression
… of the API.</p> <p>Micronized furosemide and griseofulvin were used as model API’s based on the biopharmaceutical classification system to study the effect of compression force on particle agglomeration during compression and also to study the processes and materials to prevent that …
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Isolation and Characterization of Bioactive Metabolites from Endophytic Fungi of Pinus Strobus
… Additionally, the known antifungal compound griseofulvin was quantified by LC-MS/MS.
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Metabolites of Aspergillus versicolor
… A, versicolorin C, aversin, averufin, griseofulvin, dechlorogriseofulvin and 3,8- dihydroxy-6 -methoxy-1-methylxanthone. A new metabolite was isolated and identified as 6,8-di-O-methylnidurufin. Two high-performance liquid chromatography systems were developed for the analysis of these …
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Experimental investigation of the effect of sonication on the precipitation of grieseofluvin by impinging jets
… probe (sonicator) was used to precipitate Griseofulvin, a common, poorly water-soluble antifungal drug. The drug was initially dissolved in acetone and then precipitated using water as the antisolvent. Experiments were carried out for different values of the sonication power, impinging jet …
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Batch and continuous production of stable dense suspensions of drug nanoparticles in a wet stirred media mill
… comprehensive investigation of the production of Griseofulvin nanosuspensions in a wet stirred media mill operating in both the recirculation and continuous modes has been conducted to address the aforementioned fundamental challenges. Griseofulvin has been selected as a model poorly water-soluble …
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Investigating Crystallization Tendency, Miscibility and Molecular interactions of drug-polymer systems for the development of amorphous solid dispersions
… (IND), flutaminde (FLU), dipyridamole (DIP), griseofulvin (GRI)] in absence and presence of four different polymers [i.e. polyethylene glycol (PEG), eudragit EPO (EPO), hydroxypropyl methylcellulose (HPMC) and polyvinyl pyrrolidone (PVP)] in various drug-polymer ratios were determined by using …
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Precipitation of micro/nanoparticles in enhanced high energy dissipation mixing systems
… industry, namely the precipitation of griseofulvin, a common antifungal drug, from a solution in acetone using an aqueous solution as the antisolvent. Precipitation studies were conducted to determine the role on crystal size distribution of different operating parameters, such as …
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Isolation and structure elucidation of bioactive secondary metabolites from marine sponges and sponge-derived fungi
… six compounds, namely the known antifungal griseofulvin and its less active dechloro analogue; the known toxin oxaline; and the known cytotoxic metabolite communesin B and its two new congeners communesin C and D. The new communesins were less active than communesin B in the brine-shrimp …
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The molecular mechanism of action of the antiangiogenic natural product, cremastranone
Prevention of pathological angiogenesis is a key strategy for treatment of common blinding ocular diseases such as retinopathy of prematurity, proliferative diabetic retinopathy, and wet age-related macular degeneration. The current treatment strategies are associated with partial vision loss and …