Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Grin2b"”.
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Functional consequences of mutations in GRIN2A and GRIN2B associated with mental disorders
GRIN2A and GRIN2B encode the GluN2A and GluN2B subunits of the NMDA receptor, a subtype of ionotropic glutamate receptor that displays voltage-dependent block by Mg2+ and a high permeability to Ca2+. These receptors play important roles in synaptogenesis, synaptic transmission and synaptic …
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CHARACTERIZATION OF FRONTAL CORTICAL CIRCGRIN2B_011731 IN OPIOID-INDUCED NEUROADAPATIONS
… self-administration, of these we selected circGrin2b_011731 (circGrin2b) for further characterization. circGrin2b is derived from exon 3 of linear Grin2b, which encodes the regulatory subunit of the NMDA receptor, GluN2b, a protein essential for opioid learning and memory paradigms. First, …
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A molecular approach to precision medicine in South African children with Epilepsy: towards a genetics-based diagnostic service for Epilepsy
… significance were identified in GABRG2 and GRIN2B. The findings were aligned with the electroclinical features in each patient. The pharmacogenomic analysis revealed one variant, EPHX1 rs1051740, which appeared to be statistically significantly differently distributed in the study group to …
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Genetic analysis of bipolar disorder and alcohol use disorder
… receptor, ionotropic, N-methyl D-aspartate 2B (GRIN2B) gene as being associated with brain volume in the left orbitofrontal cortex and posterior cingulate. HPA-axis genes did not show an association with AUD and no significant gene x environment interactions were detected for AUD in the ALSPAC …
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The effects of licorice root components on cognition
… of Bdnf, Ntkr2, Dlg4, Gria1, Gria2, Grin1, Grin2B, Esr1 and Esr2. There were no significant changes in the expression of any of the chosen genes with exposure to the botanical compounds or estradiol. However, there was a trend for reduced expression of three genes. Western blotting was used …