Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 20 for “"Grey Matter Volume"”.
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Genetic influence on brain volumes in psychosis.
… influence of susceptibility genes on brain volumes in psychosis. More specifically, I explored whether certain allelic variations are associated with global brain volumes in subjects with psychosis, their relatives and in healthy controls. To increase the statistical power, I combined three …
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Development of a voxel-based meta-analytic method for neuroimaging studies
… such as the separate analyses of positive (e.g. grey matter volume increases) and negative (e.g. grey matter volume reductions) findings, not accounting for the effect size, not taking sample size, intra-study variance or between-study heterogeneity into account, and not allowing combination of …
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Lexical-semantic parameters as robust endophenotypes of abnormal cognitive decline in ageing
… competency in aMCI carriers as an endophenotype, grey matter volume loss in aMCI ε4 carriers/non-carriers and in controls was compared and the residual volume correlated with allele burden and with age of acquisition values for words produced in a category fluency task. Direct group comparisons …
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Blushing and gaze avoidance in social anxiety disorder : a structural neuroanatomical investigation
… gaze anxiety and avoidance symptoms with brain volumes, controlling for total grey matter volume, age and level of education. Results: Anxiety, blushing propensity and gaze fear and avoidance symptoms were all significantly higher in SAD patients (p<0.001). Brainstem volumes were increased for …
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BRAIN STRUCTURE AND FUNCTION ASSOCIATED WITH EMOTION DYSREGULATION IN TYPICAL DEVELOPMENT AND NEURODEVELOPMENTAL DISORDERS
… employed to explore the association of ED with grey matter volume (GMV) and resting state functional connectivity (FC) in TD (study 1), and in boys with ADHD, ASD, and ADHD comorbid ASD (study 2). In study 1, gender moderated the association of ED with both GMV and FC in insula and inferior …
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Localized or diffuse: a volumetric investigation of the relation between prefrontal cortical regions and the habitual engagement of cognitive reappraisal
… engagement of the right SFC. However, previous volumetric studies have not identified clear associations between reappraisal and these regions. This discrepancy between functional and structural studies suggests that the broad functional engagement associated with reappraisal might not be …
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Lifestyle factors and neuroimaging metrics as predictors of cognitive performance in healthy aging
… In Study 1, I assessed the impact of aging on grey matter volume of the medial temporal lobe MTL and prefrontal cortex PFC and compared the relative contributions of MTL and PFC structures to age differences in associative memory. My findings emphasize the critical role of the frontal lobes, …
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Large-scale Functional Connectivity in the Human Brain Reveals Fundamental Mechanisms of Cognitive, Sensory and Emotion Processing in Health and Psychiatric Disorders
… abnormalities in SAD, which include reduced grey matter volume in the temporal pole, in addition to increased grey matter volume in cerebellum and fusiform (Chapter 8). The above findings suggest promise for emerging functional connectivity and structural-based neurobiomarkers for SAD …
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Neuroimaging Depression Risk in a Sample of Never-Depressed Children
… symptoms being negatively associated with grey matter volume in regions relevant to reward processing (i.e., orbitofrontal cortex; Study 1), functional activity in salience processing regions (i.e., anterior insula) and reward processing (i.e., putamen) during critical maternal feedback …
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Cognitive and brain markers in presymptomatic genetic behavioural variant frontotemporal dementia: a case-control study
… in presymptomatic bvFTD-MAPT by measuring grey matter volume and cortical thickness in a case-control design, covarying for age (cases n=5; controls n=16). Reductions in regions varied across cases, with more extensive reductions in some cases than others. Volumetric and cortical thickness …
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Development of human functional and structural brain networks in adolescence and its relevance to psychiatric disorders
… identified novel milestones of subcortical volume development; in particular a set of subcortical regions was defined that reached peak grey matter volume during adolescence. Furthermore, subject-specific deviations from normative, non-linear neurodevelopmental trajectories? were derived and …
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Brain substrates of behavioural endophenotypes predictive of compulsive drug-seeking
… and compulsivity were shown to predict lower grey matter volume in the infralimbic cortex and ventral striatum. Functionally, compulsivity and stickiness were predicted by decreased connectivity between the prelimbic cortex and the anterior cingulate cortex with the posterior dorsomedial …
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Behavioural and Neural Investigation of the Subjective Experience of Remembering
… In older adults, left AnG and precuneus grey matter volume positively correlated with the adoption of a first-person recall perspective, but not first-person recall more generally. These parietal volumes were further shown to decline with age. Finally, the experiment in Chapter 4 …
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Neurocognitive risk and protective factors in addictive disorders
… 6 a similar decline in orbitofrontal cortex grey matter volume in relation to both years of stimulant use and body mass index was identified, implicating an overlap in this area between both conditions. These findings are integrated in Chapter 7, discussing the neurocognitive risk and …
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Neural Mechanisms of Motor Imagery and Training-Induced Plasticity: Hypnotizability Relevance to Microgravity Adaptation
… to low hypnotizables (lows) - i.e., reduced grey matter volume of the insula and of the cerebellar left lobules IV-VI -, and behavioral/physiological differences, i.e., greater functional equivalence (FE) between actual and imagined perception/action, greater excitability of the motor cortex, …
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Understanding mechanisms related to psychosis in Motor Neurone Disease
… Using a Freesurfer regions-of-interest approach, grey matter volume correlated inversely with CBI-R psychosis index in the caudate, amygdala, cingulate and hippocampus. Using tract-based spatial statistics, increased mean diffusivity (MD) of diffusion weighted imaging correlated with the CBI-R …
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DNA methylation of the clusterin promoter: Associations with Alzheimer’s Disease risk and related phenotypes
… at CpG_15 positively correlated with cortical grey matter volume. Within HC’s, increased methylation at CpG_1, CpG_2_3, CpG_8_9, CpG_14, CpG_16, CpG_19, and decreased methylation at CpG_20_21, CpG_23_24, CpG_25_26_27_28, CpG_36, CpG_38_39 and CpG_41 were associated with a higher brain A …
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An overview of blood-based biomarkers in AD
… positively associated to increased ventricular volume, while ApoA-II/ApoA-I and ApoJ/ApoA-I ratios are positively associated with grey matter volume, hippocampal volume and are negatively associated with ventricular volume. Taken together, these data indicate that plasma HDL composition is …
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Social-semantic knowledge and behavioural changes in frontotemporal dementia
… occurred despite similar levels of overall ATL volume. In Chapter 5, I used a battery of informant questionnaires to explore the range and nature of behavioural changes in FTD, and tested the hypothesis that social-semantic knowledge is related to impaired social behaviour in FTD. By recruiting …
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A neuroimaging study to characterise adolescent major depressive disorder, the effects of cognitive behavioural therapy, and potential subtypes based on familial loading
… differences in cortical thickness, white matter volume, and resting-state functional connectivity, using the largest studied sample of adolescent MDD patients under the age of 18 years. This thesis further aimed to investigate CBT’s effects on brain function, and whether adolescent MDD …