Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Gremlin 1"”.
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Disruption of Immunoregulatory Functions of Intestinal Mesenchymal Stromal Cells and their Progenitors in Inflammatory Bowel Disease
… is altered in IBD for as yet unknown reasons. Gremlin 1+ (Grem1) Mesenchymal Stromal progenitor Cells (MSCs) are progenitors of CMFs under homeostasis, but their fate during IBD immunopathogenesis is unknown. I hypothesize that PD-L1 expressed by CMFs is a critical driver of immune imbalance in …
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Specific forms of TCF7L2 protein define the Wnt pathway dependent genetic program
… organoid media growth factors, R-spondin1 and Gremlin-1, that were produced from bacterial expression and optimised for organoid culture. I further investigated whether R-spondin1 could be further engineered to increase its potency in organoid growth media. My strategy was to introduce …
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The Role of Gremlin1 in Multiple Myeloma
… defined. The studies presented here show that Gremlin1 (Grem1), a highly conserved protein, which is abundantly secreted by a subset of BM mesenchymal stromal cells, plays a critical role in MM disease development. We describe, for the first time, a novel positive feedback loop between MM PCs …