Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"Granulosa cells"”.
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MICRORNA EXPRESSION WITHIN PERIOVULATORY MURAL GRANULOSA CELLS
… ovulation is initiated as a surge of LH induces granulosa cells to rapidly transform from estrogen producing follicular cells to progesterone producing luteal cells. The molecular mechanisms involved with the follicular to luteal transition have been extensively studied, and many transcriptional …
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Expression of DIO2 in the Porcine Ovary and the Granulosa Cells of Humans
… cycles. As follicles develop, the somatic cells of the ovary differentiate into granulosa cells and theca cells. Following a luteinizing hormone surge these cells further differentiate into small and large luteal cells and steroidogenesis increases. The rate-limiting step in steroidogenesis …
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Lineage specification of ovarian theca cells requires multi-cellular interactions via oocyte and granulosa cells
… determinations of ovarian surface epithelium, granulosa cells, and theca cells. While the sources of ovarian surface epithelium and granulosa cells are known, the embryonic origin(s) of theca stem/progenitor cells have not been definitively identified. Here I show that theca cells derive from …
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Hormone Stimulable Adenylyl Cyclase Activity in Ovarian Granulosa Cells of the Domestic Hen (Gallus Domesticus)
The hormone stimulable AC of chicken granulosa cells was characterized and was found to be similar to that of mammalian reproductive tissues under the conditions tested. A principal difference, however, is the stability of the enzyme. Gonadotropin dose response studies suggest that there is an …
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Follicle stimulating hormone and steroidogenesis in ovarian granulosa cells during aging in the domestic hen
There is a decreased rate of follicular maturation with age in the domestic hen. The time required for follicular growth increases, while the number of growing follicles decreases. The causes for this physiological change with age are not defined. Perhaps there are changes with age in the …
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Stress Fiber Formation and Migration Are Novel PGR-Dependent Pathways Initiated in the Granulosa Cells of the Ovulating Follicle
… Analysis of 154 key PGR-dependent genes in granulosa cells identified ‘formation of actin filaments’ and ‘formation of stress fibers’ as primary pathways. In contrast, RNA-seq analysis of the ovarian stromal compartment found minimal PGR-dependent regulation of stromal genes. It was then …
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Interaction of growth hormone and insulin-like growth factor-I in the control of steroidogenesis by cultured porcine granulosa cells
… IGF-II) on steroidogenesis in cultured porcine granulosa cells were investigated with emphasis on the interaction between GH and IGFs. Experiment one was conducted to examine the influence of metabolic hormones and growth factors on progesterone and estradiol secretion by porcine granulosa cells …
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Physiology of the germinal disc region in preovulatory follicles of the chicken ovary
… in the proliferation and differentiation of the granulosa layer. Specifically, the objectives were: (1) to determine if proliferation and differentiation of granulosa cells overlying the germinal disc was different throughout the final stages of follicular development than granulosa cells located …
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The Role of Gonadotropic Hormones in Follicular Maturation of the Domestic Hen
… (AC) activity and progesterone (P) secretion in granulosa cells as well as the role of follicle-stimulating hormone (FSH) receptors on granulosa cells during follicular maturation.
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Extraovarian and Intraovarian Control of Follicular Selection in the Chicken Ovary
… (EGF), an intraovarian hormone, suppresses granulosa cell differentiation. However, the precise regulation and interactions of these hormones on follicular selection and the expression of their receptors have not been determined. The objectives of this study we (1) develop and validate a …
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Role and regulation of prostaglandin production in granulosa cell DNA synthesis during ovarian follicular development.
… in the mitogenic actions of TGF$\alpha$ on granulosa cells during follicular development, as well as its involvement in the regulation of urokinase plasminogen activator, an enzyme playing an important role in tissue remodelling. Granulosa cells from the first (F1), fifth, and sixth (F5-6) …
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PGE2 Receptor Subsets Mediate HCG Regulation of the Plasminogen Activator/Plasmin System in Primate Periovulatory Follicles
… are present in monkey periovulatory follicles, granulosa cells and whole ovaries were collected 0, 12, 24, and 36 hours after administration of an ovulatory dose of human chorionic gonadotropin (hCG), or 36 hours after hCG from monkeys that received the prostaglandin (PG) synthesis inhibitor …
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Biochemistry of ovarian cells in vitro
… role(s) of prostaglandins in semen is discussed. Granulosa cells obtained from human Graafian follicles can be induced to luteinize in tissue culture, if given optimum gonadotrophic support, and so provide a convenient in vitro model of the progesterone secreting cells of the human corpus luteum. …
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The role of endothelin-2 in ovulation
… ovulation, the oocyte and associated cumulus cells are expelled from the ovary and travel to the ampulla of the oviduct where fertilization occurs. Concurrently, granulosa and theca cells of an ovulating follicle luteinize and form lutein cells of the highly vascular corpus luteum, which …
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Effect of aging on metabolic status and hormone responsiveness in the ovary
… of mares' ages on gene expression in granolosa cells. Most of the effects we noted were on the expression of AMPK subunits, italics indicating genes rather than gene protein products, although there were significant effects of animal age on GLUT4 and IGF-1R expression as well. In general, …
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GDF9 and BMP15: species difference and synergistic interactions.
… in thymidine incorporation in mouse and bovine granulosa cells. However, not only did we find a species difference due to the species of the protein, but also a difference due to the species of the cells on which the proteins were acting. GDF9 and BMP15 were found to interact synergistically on …
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Morphogenesis and Female Fate Determination in Vertebrates
… which is made by a population of somatic cells known as the bipotential supporting cell precursors, determines whether an embryo will develop as a phenotypic male or female. Though several molecular pathways have been shown to be required for female fate determination in vertebrates, the …
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The role of vascular endothelial growth factor isoforms in early follicle development
… has been localized to nonvascular follicles and cells. Alternative mRNA splicing of 8 exons from the VEGFA gene results in the formation of different VEGFA isoforms. Each isoform has unique properties and is identified by the number of amino acids within the mature protein. Proangiogenic isoforms …
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