Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 344 for “"Gram-negative bacteria"”.
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Bioremediation of hexavalent chromium using gram-negative bacteria.
… Cr (VI) removal using five environmental Gram-negative bacterial strains, three of which were nosocomial strains. The potential of live and autoclaved bacterial strains was investigated to mitigate Cr (VI) from its initial concentration of 2.54 mg/1. The autoclaved bacteria were used to …
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Comparative Genomics of Selected Species of Gram-Negative Bacteria
… provide insight into the evolutionary history of bacterial species. However, complete genome sequencing is not yet practical for large strain collections at the beginning of this project. In this project PCR-based methods to investigate the genomic diversity of non-sequenced strains were …
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An investigation of intrinsically disordered proteins in Gram-negative bacteria
Sporulation in Gram-positive bacteria results in the production of small acid-soluble proteins (SASPs) to coat the spore DNA and shield it from UV radiation. While orthologs of these SASPs exist in many sporulating and non-sporulating bacteria, they are noticeably absent from the Gram-negative …
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Characterizing and Overcoming Resistance to Aminomethylspectinomycins in Gram-negative Bacteria
… has led to widespread resistance in enteric bacteria, necessitating the development of more effective analogs. Aminomethyl spectinomycins (amSPC) are modified spectinomycins with increased potency against many bacterial species. These species include Legionella pneumophila, which harbors a …
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Cargo delivery into gram-negative bacteria via enterobactin uptake machinery
… an overview of iron homeostasis in human and bacteria, as well as the biology and chemistry of siderophores and siderophore conjugates. Siderophores are small-molecule iron chelators synthesized by bacteria for scavenging iron from the environment. Their iron-binding properties, structures, …
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The postantibiotic effect of the carbapenem antibiotics on gram-negative bacteria
… agents that exhibit a significant PAE on Gram-negative bacilli. A standardised method was developed to evaluate the in vitro PAE of three carbapenems; imipenem, meropenem and biapenem on Gram-negative bacteria under reproducible laboratory conditions that partially mimicked those occurring …
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Development of predictive guidelines for compound accumulation in gram-negative bacteria
New antibiotics to combat drug-resistant Gram-negative pathogens are urgently needed. Most small molecules are unable to rapidly traverse the outer membrane of Gram-negative bacteria and accumulate inside these cells, making the discovery of drugs against these pathogens challenging. Current …
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Antimicrobial Activity of Human Leukocyte Defensin HNP-4 Against Gram-negative Bacteria
… plays a special role in helping neutrophils kill gram-negative bacteria.<br /><br />Activity of HNP-4 against gram-negative bacteria is of special interest because Aggregatibacter (Actinobacillus) actinomycetemcomitans (A.a.) and other periodontal pathogens are gram-negative. These bacteria are …
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Lactose Operon Expression and Plasmid Rearrangement in Rhodopseudomonas Sphaeroides (Gram Negative Bacteria)
Genetic tools were developed to study gene regulation in Rhodopseudomonas sphaeroides. In initial studies expression of the transposable lac operon, Tn951, was examined. Very low levels of (beta)-galactosidase were observed in R. sphaeroides but mutants of this bacterium were recovered that were …
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The effect of antibiotic resistance on bacterial cell maintenance In gram-negative bacteria
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-05-01
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Characterization of small-molecule accumulation trends and novel antibiotics in Gram-negative bacteria
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-05-01
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Periplasmic Modification of the 1-Phosphate Group of Lipid A in Gram-Negative Bacteria.
… for the pathogenesis and virulence of various Gram-negative bacteria. The major lipid A species of <em>Helicobacter pylori</em> is significantly different from that of <em>Escherichia coli</em>. <em>H. pylori</em> lipid A contains fewer acyl chains and phosphate groups with only one Kdo sugar …
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Physicochemical trends of compound efflux in gram-negative bacteria and characterization of novel antibacterials
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-08-01
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Predictors of Carbapenem Resistant Gram-negative Bacteria in a Consortium of Academic Medical Center Hospitals
<p>Background: Gram-negative resistance is a growing problem worldwide. It is generally believed that rates of resistant bacteria within a hospital are a function of antibiotic use, resistant organisms brought into the hospital, infection control efforts, and underlying severity of patient illness. …
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The recognition of lipopolysaccharides present in Gram-negative bacteria by receptors of the immune system
Invasive bacterial infections cause severe systemic complications including a life-threatening condition known as septic shock. Sepsis results in a dysregulated systemic inflammatory immune response with systemic consequences. The function of the immune system requires efficient communication …
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Enhanced sampling methods and their application in the study of molecular permeation in gram-negative bacteria
… proteins filling their outer membrane, gram- negative bacteria are able to reduce the rates at which specific polar compounds are able to permeate. A clear comprehension of the mechanism determining substrates diffusion through these pores is still missing. In this thesis, we show how …
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The influence of positively charged nitrogen species on compound accumulation and activity in gram-negative bacteria
Multidrug resistant Gram-negative bacterial infections are on the rise, and with no FDA approvals for new classes of broad-spectrum antibiotics in over 50 years, these infections constitute a major threat to human health. A significant challenge is the inability of most compounds to accumulate in …
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Discovery and Characterization of an Antibacterial Metabolite, Produced by a Death Valley Soil Microbe, Active Against Gram-Negative Bacteria
… count could rise to 10 million by 2050. Notably, Gram-negative bacteria account for the majority of alerts due to their intrinsic multidrug resistance mechanisms, impermeable outer membranes, and rapid acquisition of additional resistance genes. To address the urgent need for novel antibiotics, we …
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A Study on the Prevalence of Gram-Negative Bacteria Isolated from Bulk Tank Milk with Special Reference to Pseudomonas Fluorescens
… study was conducted to study the prevalence of Gram-negative bacteria in bulk tank milk (n = 131) in eastern South Dakota and western Minnesota. A total of 130 bulk tanks (BTs) were examined for coliforms. Coliforms were detected in 62.3% of BTs, and ranged from 0-4.7 log10 cfu/ml, with a mean …
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