Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 821 for “"Gram-negative"”.
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Bioremediation of hexavalent chromium using gram-negative bacteria.
… Cr (VI) removal using five environmental Gram-negative bacterial strains, three of which were nosocomial strains. The potential of live and autoclaved bacterial strains was investigated to mitigate Cr (VI) from its initial concentration of 2.54 mg/1. The autoclaved bacteria were used to …
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Acquired Carbapenemases in Gram-Negative Bacilli in Singapore
… that the increase in carbapenem-resistance in Gram-negative bacilli in Singapore is due to the introduction of global clones of carbapenemase-producing strains with the potential to cause outbreaks. The diversity of acquired carbapenemase genes in Singapore, their distribution among different …
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The Role of Gram - Negative Anaerobes in Hidradenitis Suppurativa
… and infectious trigger of pathogenesis. Gram-negative anaerobic bacteria (GNA) such as Prevotella, Porphyromonas, and Fusobacterium are commonly identified in HS lesions, and their prevalence in lesions is associated with HS disease severity. Additionally, newly epithelialized structures …
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Enzyme Mediated Gentamicin Resistance Among Gram-Negative Clinical Isolates
… to be effective in the treatment of serious gram- negative bacillary infections (1-5). Gentamicin is one of the few antimicrobial agents available for the treatment of life- threatening infections due to Pseudomonas aeruginosa (114-116), an organism of increasing etiological significance in …
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Comparative Genomics of Selected Species of Gram-Negative Bacteria
Investigation of genomic diversity can provide insight into the evolutionary history of bacterial species. However, complete genome sequencing is not yet practical for large strain collections at the beginning of this project. In this project PCR-based methods to investigate the genomic diversity …
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Synthesis and translation of novel gram-negative antibacterial agents
… with enhanced permeation into bacteria, with gram-negatives especially being a problem due to their characteristic dual membrane. This dissertation describes the use of general permeation guidelines for enhancing small molecule accumulation in gram-negative bacteria to inform the discovery and …
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Chemical synthesis in the campaign against Gram-negative pathogens
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2027-05-01
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Responses of an Environmental Gram-negative Bacterium to Pollutant Stress
Several strains of pseudomonads which are normally found in natural water and soil environments, including Pseudomonas fluorescens, Pseudomonas aeruginosa, and strains initially identified as Pseudomonas paucimobilis and Pseudomonas maltophilia, were used in this thesis and their stress responsive …
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Biochemical characteristics and antibiogram patterns of some gram-negative nonfermentors
… A second objective was to compare the antibiogram patterns obtained in this study with those reported by other investigators, and thirdly to establish a baseline for future comparative studies.
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An investigation of intrinsically disordered proteins in Gram-negative bacteria
Sporulation in Gram-positive bacteria results in the production of small acid-soluble proteins (SASPs) to coat the spore DNA and shield it from UV radiation. While orthologs of these SASPs exist in many sporulating and non-sporulating bacteria, they are noticeably absent from the Gram-negative …
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Characterizing and Overcoming Resistance to Aminomethylspectinomycins in Gram-negative Bacteria
… in vivo but are inactivated by ANT (3")(9). Most Gram-negative bacteria isolated in clinics possess one or more AMEs. By overcoming modification by AMEs, amSPCs can be a valuable tool in overcoming resistance in Gram-negative bacterial infections. We also conducted a high throughput screen of a …
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Protein glycosylation in the gram-negative gamma proteobacterium photorhabdus luminescens
The objective of this research was to investigate the possibility that Photorhabdus luminescens produces glycoproteins and thus contains a protein glycosylation system. P. luminescens is a pathogen of insects and a symbiont of soil nematodes. Adhesion and invasion are very important in the life …
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X-ray diffraction of a gram-negative bacterial membrane mimetic
… '3 , but not the cells of the host animal? For gramnegative bacteria, the most likely reason is that t Ileir outer membrane is made of lipopolysaccharides (LPS), which is very different from an animal :;ell membrane. Up to now, what we knovv about how these peptides work was likely done with r …
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Cargo delivery into gram-negative bacteria via enterobactin uptake machinery
… is synthesized to probe the extent to which the Gram-negative ferric Ent uptake and processing machinery recognizes, transports, and utilizes derivatized Ent scaffolds. The delivery of Ent-cargo conjugates is evaluated by a series of growth recovery assays. The results demonstrate that the …
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The postantibiotic effect of the carbapenem antibiotics on gram-negative bacteria
… agents that exhibit a significant PAE on Gram-negative bacilli. A standardised method was developed to evaluate the in vitro PAE of three carbapenems; imipenem, meropenem and biapenem on Gram-negative bacteria under reproducible laboratory conditions that partially mimicked those occurring …
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Development of LolCDE inhibitors as microbiome-sparing gram-negative-selective antibiotics
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-08-01
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Development of predictive guidelines for compound accumulation in gram-negative bacteria
New antibiotics to combat drug-resistant Gram-negative pathogens are urgently needed. Most small molecules are unable to rapidly traverse the outer membrane of Gram-negative bacteria and accumulate inside these cells, making the discovery of drugs against these pathogens challenging. Current …
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Detection and characterisation of carbapenem-resistant gram-negative bacilli infections in Ghana
… (111 of 3840) was detected from the total of Gram-negative bacterial pathogens. In MIC E-test assays, 56.8% of CR isolates showed complete resistance to imipenem, meropenem and ertapenem at ≥32 μg/ml, of which 24.3% were found in Pseudomonas aeruginosa isolates and 18.9% in Acinetobacter …
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