Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Gram-Negative Bacterial Infections"”.
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Investigating Pulmonary Immune Responses that Detect and Counteract Gram-negative Bacterial Infections
Infections of the lungs can cause tremendous tissue damage which often leads to pathogens spreading into the bloodstream. In the airways, Gram-negative bacteria produce biofilms through exopolysaccharide (EPS) that provides microbial protection; however, the impact of EPS on detection remains …
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The Design and Synthesis of Novel Antimicrobial Agents for Use in the Battle Against Bacterial Resistance
… of action. Chapter 3 discusses the treatment of gram-negative bacterial infections with novel hybrid antimicrobial agents. These agents afford current antimicrobial agents, which have difficulty penetrating the gram-negative cell wall, a way into the gram-negative cell in order to exert their …
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Constitutive Overexpression of Acyloxyacyl Hydrolase in Mus Musculus
… chains from lipid A, the bioactive center of Gram negative bacterial lipopolysaccharide (LPS). Deacylated LPS has a marked reduction in bioactivity and antagonizes the LPS signaling pathway. Thus, AOAH deacylation of LPS may represent a mechanism by which animals control responses to …
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The influence of positively charged nitrogen species on compound accumulation and activity in gram-negative bacteria
Multidrug resistant Gram-negative bacterial infections are on the rise, and with no FDA approvals for new classes of broad-spectrum antibiotics in over 50 years, these infections constitute a major threat to human health. A significant challenge is the inability of most compounds to accumulate in …
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Enzymology of Gentamicin Biosynthesis
… toxicity remains valuable to treat severe Gram-negative bacterial infections. There is a pressing need to develop novel versions of such antibiotics to combat the rise of resistance among pathogens. Engineering of the pathway requires a detailed knowledge of the genes, enzymes, and …
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Novel cytokines in innate immunity: IL-27 and IL-30 enhance responsiveness to gram-negative bacterial components in human myeloid cells
… mechanisms to improve treatments for bacterial infections. IL-27 is comprised of IL-27p28 and EBI3 subunits; the IL-27p28 subunit, also named IL-30, can also signal independently of EBI3. To date, most studies on IL-27 have focused on its role in CD4+ T cell differentiation. IL-30 has …
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Characterizing and Overcoming Resistance to Aminomethylspectinomycins in Gram-negative Bacteria
… with increased potency against many bacterial species. These species include Legionella pneumophila, which harbors a chromosomally encoded aminoglycoside modifying enzyme (AME). In this study, we follow up on this observation and examine the extent to which the amSPCs are substrates …
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Antibacterial activity and mode of action of the antimicrobial peptide CPF-MW1 against Escherichia coli ATCC 700928
… The development of new antimicrobials against Gram-negative bacterial infections is especially challenging due to the structural complexity of the bacterial cell wall. Antimicrobial peptides (AMPs) have been identified as important antimicrobial leads for drug development due to their …
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Structure-Based Drug Design in Medicinal Chemistry I. Development of Translesion Synthesis Inhibitors II. Synthesis and Biological Evaluation of Sulfonyl Piperazine Derivatives for LpxH Inhibition
… Lipid A has a critical role in host response to bacterial infection and thus is required for the growth and survival of most Gram-negative bacteria. An effective therapeutic targeting lipid A biosynthesis can cure Gram-negative bacterial infections and sensitize infectious bacteria to other …
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Recurrent Urinary Tract Infections Due to Bacterial Persistence or Reinfection in Women: Does This Factor Impact Upper Tract Imaging Findings? A Quality Improvement Project
… that women with recurrent urinary tract infections (RUTIs) due to bacterial persistence (same strain) undergo upper urinary tract imaging to evaluate for sources of their infection. OBJECTIVE: To compare the rate of upper tract imaging abnormalities between RUTIs due to bacterial …
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Cochlear Sensitization to Aminoglycosides: Defining the Role of JAK-STAT Signaling
… remain essential for treatment of severe Gram-negative bacterial infections, yet their clinical use is limited by the risk of irreversible sensorineural hearing loss. Many signaling pathways change during ototoxic injury, but transcriptional change alone does not establish whether a …
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Effects of Lipopolysaccharide Induced Inflammatory Response on Early Embryo Survival in Ewes
… as a model to study early embryonic loss via gram-negative bacterial infections, such as mastitis. Ewes 5/6 dpc were injected with a gram-negative bacteria cell wall component, lipopolysaccharide (LPS) or tumor necrosis factor-alpha (TNF-&agr;), to induce an innate immune system acute phase …