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Showing 1 to 20 of 42 for “"Graft-versus-host Disease"”.

  1. Bilirubin Nanoparticle As An Anti-Inflammatory Therapy For Graft Versus Host Disease

    Pareek, Sumedha, <p>https://orcid.org/0000-0001-6492-3849</p>2019

    <p>Graft versus host disease (GvHD) caused by alloreactive donor lymphocytes is a fatal complication of hematopoietic stem cell transplant (HSCT). Myeloablative conditioning regimen, consisting of chemotherapy and/or radiation, given prior to HSCT can cause tissue damage. This non-specific tissue …

    uthsc Repository record

  2. Immune Mechanisms of Mesenchymal Stem Cell Therapy for Acute Graft versus Host Disease

    Tobin, Laura M.National University of Ireland Maynooth2012

    … for the treatment of inflammatory and autoimmune diseases, such as acute Graft versus Host Disease (aGvHD) and Crohn’s disease. However, the exact mechanisms of therapeutic benefit remain unclear. The key goals of this study were to identify the role of MSC derived soluble and contact dependent …

    maynooth Repository record

  3. Immunological Mechanisms of Extracorporeal Photopheresis In Cutaneous T Cell Lymphoma and Graft Versus Host Disease

    Shiue, Lisa2013

    … PHOTOPHERESIS IN CUTANEOUS T CELL LYMPHOMA AND GRAFT VERSUS HOST DISEASE</strong></p> <p>Publication No.___________</p> <p>Lisa Harn-Ging Shiue, B.S.</p> <p>Supervisory Professor: Madeleine Duvic, M.D.</p> <p>Extracorporeal photopheresis (ECP) is an effective, low-risk immunomodulating therapy …

    uthsc Repository record

  4. THE DEVELOPMENT OF SELECTIVE PHOTOSENSITIZERS TO TARGET PATHOGENIC T CELLS AND PREVENT GRAFT-VERSUS-HOST DISEASE

    McIver, ZachariahWake Forest University2017

    … disorders, including autoimmune and alloimmune diseases. In hematopoietic stem cell transplantation, acute graft-versus-host-disease (GVHD) is caused by an attack on the recipient's tissues from donor allogeneic T cells. In cutaneous T cell lymphoma (CTCL), malignant T cells migrate throughout …

    wfu Repository record

  5. Investigating The Role of Il-10 Producing Nkt Cells In Prevention of Graft Versus Host Disease

    Boagni, Drew, <p>0009-0001-9639-5064</p>2023

    … healthy donor. This can lead to cure through the graft versus leukemia (GVL) effect but can also cause graft versus host disease (GVHD), which is characterized by systemic inflammation and organ damage mediated by dysregulated donor T cells. Preclinical studies have shown invariant natural killer …

    uthsc Repository record

  6. Signaling pathways and novel therapeutic strategies for the treatment of murine chronic graft versus host disease

    Paz, Katelyn2018

    … for hematological malignancies. Chronic graft-versus-host disease (cGVHD) is a long-term immune complication following aHSCT and a leading cause of non-relapse mortality. The standard of clinical management of broad immunosuppression by corticosteroids has been largely unchanged in …

    umn Repository record

  7. EPI-X4 als Peptid-Biomarker für die Diagnose und Prognose der akuten Graft-versus-Host-Disease

    Sauer, Sarah StefanieUniversität Ulm

    ulm-diss Repository record

  8. Pathogenesis of Dry Eye in Graft Versus Host Disease (GVHD): Role of Ocular Mucins and Conjunctival Fibrosis

    Shamloo, Kiumars

    … marrow transplantation’s major side effect i.e Graft vs. Host Disease (GVHD). GVHD is a complex, multi-organ disease resulting from an immunological attack by donor engrafted immune cells to host organs, including the eye surface. Mostly based on the time of disease onset after transplantation, …

    chapman Repository record

  9. A Delineation of Mesenchymal Stromal Cell Therapeutic Action in New Models of Acute and Chronic Graft versus Host Disease

    Healy, Marc E.National University of Ireland Maynooth2015

    … the treatment of inflammatory and auto-immune disease, and has already demonstrated beneficial effects during GvHD and Crohn’s disease. However, the mechanisms employed by MSC therapy to modulate disease progression have not been identified. The key goals for this thesis were (1) to determine …

    maynooth Repository record

  10. The stimulatory role of ICOS in the development of CD146+CCR5+ T cells co-expressing IFN-γ and IL-17 during graft-versus-host disease

    Liu, Liangyi2015

    Graft-versus-host disease (GVHD) remains the major complication after allogeneic hematopoietic stem cell transplantation (HSCT), resulting from immunological attack on target organs such as gastrointestinal (GI) tract, liver and skin from donor allogeneic T cells. The most common treatment for GVHD …

    iupui Repository record

  11. The role of HLA-G in bone marrow transplantation

    Λαζανά, Ιωάννα2014

    … physiological immunotolerance of semi-allografts. In this context, we investigated the putative role of this molecule in the allogeneic hematopoietic cell transplantation setting. The percentage of HLA-G+ cells in peripheral blood of healthy donors and allo-transplanted patients was …

    patras-thes Repository record

  12. Role of Lymphocyte Populations Following Allogeneic Haematopoietic Stem Cell Transplantation // Роля на лимфоцитните популации след алогенна трансплантация на хемопоетични стволови клетки

    Petrov, Yavor, Петров, ЯворMedical University of Varna2025

    … associated with a number of complications – graft-versus-host disease (GVHD), infectious complications (viral, bacterial, fungal), non-infectious complications (dysfunction of various organs and systems), and delayed or incomplete recovery of the immune system. Following allo-HSCT, immune …

    varna Repository record

  13. Outcome of Severe Aplastic Anemia Treated with Immunosuppressive Therapy Compared with Bone Marrow Transplantation

    김, 형일2011

    … 6 patients developed grade II to III acute graft-versus-host-disease (GVHD) and 3 patients developed chronic GVHD. The median survival time in all patients was 60.27 months, the 5-year survival rate was 61.0% in the IST group and 81.9%(p=0.144) in the BMT group. The factors influencing …

    ajou Repository record

  14. Engineering B Cells For Use In Immunotherapy and Cancer

    Ensley, Emily, <p>https://orcid.org/0000-0003-4212-2260</p>2022

    … to control inflammatory responses in multiple diseases through the production of anti-inflammatory cytokines, including interleukin (IL)-10, IL-35 and transforming growth factor-beta (TGF-b). Ex vivo expansion of B cells has been challenging due to their tendency to undergo apoptosis in …

    uthsc Repository record

  15. Il trapianto di midollo osseo aploidentico nelle patologie oncoematologiche: studio clinico

    Isidori, Alessandro <1974>Alma Mater Studiorum - Università di Bologna2008

    … Quattro pazienti su 7 hanno svillupato una Graft versus Host Disease (GVHD) acuta di grado II-IV, mentre soltanto 1/7 ha sviluppato una GVHD cronica. Sette pazienti su 10 trapiantati hanno ottenuto una remissione completa successivamente al trapianto. Di questi, attualmente 2 pazienti sono …

    bologna Repository record

  16. Molecular Characterization of the Human Alloimmune Response

    Smith, Melody2009

    … in vitro proliferations translate in vivo into graft rejection of stem cell and solid organ transplants and to graft versus host disease (GvHD) in recipients of allogeneic stem cell transplants. Defining the clonal T cell responses elicited in an MLR between two individuals is complicated by the …

    tdl Repository record

  17. Molecular Characterization of the Human Alloimmune Response

    Smith, Melody2011

    … in vitro proliferations translate in vivo into graft rejection of stem cell and solid organ transplants and to graft versus host disease (GvHD) in recipients of allogeneic stem cell transplants. Defining the clonal T cell responses elicited in an MLR between two individuals is complicated by the …

    utswmed Repository record

  18. Exploring Veto Activity: DNAM-1-CD155 Axis in Overcoming NK Cell-Mediated Allo-Rejection and Applications for CAR-T Cell Therapy

    Liu, Wei-Hsin, <p>https://orcid.org/0000-0003-4670-7485</p>2026

    … veto activity, it enables cells to target host cytotoxic T lymphocyte (CTL) precursors specific to veto cells' antigens, selectively eliminating anti- donor T cell clones without inducing rejection. By leveraging this unique immune property, two key research aims were proposed: “Exploration …

    uthsc Repository record

  19. Pathogenic Mechanisms Underlying Immune Dysregulation Associated To Hypomorphic RAG2 Mutation: Role Of Microbiota At Mucosal Interfaces

    Rigoni, RositaThe Open University2018

    … patients present symptoms very similar to graft-versus-host disease (GVHD) as inflammatory reactions particularly involve the environmental interfaces such as the skin and gut, leading to distinctive early onset erythroderma and protracted diarrhea. However, the complete comprehension of …

    the-open-u Repository record

  20. Biodistribution and Modes of Action of Multipotent Adult Progenitor Cell therapy in Murine Models of Transplant Rejection

    Carty, FionaNational University of Ireland Maynooth2018

    T cell homeostatic proliferation (HP) and Graft versus Host Disease (GvHD) are major barriers to the success of transplantation. Multipotent Adult Progenitor Cells (MAPC cells) have demonstrated promising safety and therapeutic profiles in experimental models and small clinical trials of …

    maynooth Repository record

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