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Showing 1 to 20 of 55 for “"Gp130"”.
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Untersuchungen zur gp130/Jak1-Interaktion
The common receptor subunit gp130 is essential for cellular responses following stimulation with IL-6-type cytokines. Signal transduction via gp130 occurs through activation of constitutively associated kinases of the Janus family (Jak1, Jak2 and Tyk2). Since Jak1 plays the most important role the …
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Charakterisierung der Interaktion von gp130 und Jak1
… of this dissertation is the interaction of gp130 and Jak1. Two aspects of this interaction were the main focus: Using FRAP (fluorescence recovery after photobleaching), it was demonstrated that there the kinase Jak1 has the same mobility as gp130 regardless of its kinase activity. This means …
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STAT3-protein interactions in IL-6/gp130 signaling
… central transcription factor downstream of IL-6/gp130 signaling. This thesis investigates how STAT3 regulates IL-6 signal transduction by interacting with its coactivators. First, the function of an IL-6 inducible complex of STAT3 with cyclin-dependent kinase 9 (CDK9) was examined by using …
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Untersuchungen zum Aktivierungsmechanismus des Signalübermittlers gp130 und Bedeutung seiner juxtamembranären Region
The glycoprotein 130 (gp130) is the common signal transducing receptor chain of the interleukin-6 family of cytokines. Here requirements for transfer of the information given by ligand binding to the cytoplasmic domain of gp130 were investigated. Mutagenesis studies of the transmembrane domain …
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Repression der IL-6-Signaltransduktion über das zytoplasmatische Tyrosin 759 des Signaltransduktors gp130
This study revealed that tyrosine motifs of gp130 which have been described to recruit STAT-proteins are not equivalent in respect to their potential to activate STAT-factors, acute-phase protein gene promoters and in induction of proliferation. To investigate the potential of each tyrosine-motif …
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Bestimmung der Lösungsstruktur der dritten Extrazellulärdomäne des Signaltransduktors gp130 mittels mehrdimensionaler heteronuklearer NMR-Spektroskopie
The signal transducer gp130: Solution structure of the carboxy-terminal domain of the cytokin receptor homology region. The transmembrane glycoprotein gp130 is the common signal transducing receptor subunit of the interleukin-6-type cytokines. It is a member of the cytokin-receptor superfamily …
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Relevanz der Transmembran- und Intrazellulärregion von gp130, LIFR und OSMR für deren Liganden-induzierte Signaltransduktion
… chains in order to transmit signals into cells: gp130, LIFR and OSMR. Here it could be demonstrated that the signal transducing capacities of LIFR and gp130 are highly redundant. The box1/2 region of the LIFR recruits the Janus kinases Jak1, Jak2 and Tyk2; the membrane distal tyrosine residues …
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Role of IL-6/gp130-dependent signalling pathways in hepatocytes during liver regeneration and inflammation
The signal transducer gp130 initiates cellular events started by induction of JAK kinases resulting in Ras/Erk-mediated signalling and activation of STAT transcription factors, particularly STAT3. Within the present studies the role of the Interleukin-6 (IL-6) receptor gp130 in hepatocytes was …
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Analyse der Wechselwirkungen von Proteinen des Interleukin-6-Signalwegs in einzelnen Zellen
… signalling subunit of the IL-6-type cytokines gp130 and the Janus kinase Jak1 was revealed by fluorescence recovery after photobleaching (FRAP) analysis. Signal transduction through cytokine receptors is mediated mainly by non-covalently associated Jak tyrosine kinases. By confocal microscopy, …
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Charakterisierung fluoreszierender Varianten des Zytokinrezeptors gp130 hinsichtlich biologischer Aktivität und Dimerisierung mit molekularbiologischen und fluoreszenzspektroskopischen Methoden
The glycoprotein gp130 is expressed as a trans-membrane receptor on the cell surface of many cells. Because of its function as a central signal transducer component of the cytokines IL-6, IL-11, LIF, CNTF, OSM and CT-1 the behaviour of gp130 towards its ligands is of major interest. For IL-6 the …
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Untersuchungen zur Zytokinbindung und Rezeptoraktivierung des Signaltransduktors gp130 durch seine Liganden IL-6 und IL-11
The glycoprotein 130 (gp130) is expressed as a transmembrane receptor on the cellsurface of many cells. It acts as the central signal transducing subunit of the family of IL-6-type cytokines thereby initiating several biological responses. The aim of this work was to characterize the properties of …
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Das Tyrosin 759 des Signaltransduktors gp130 in der IL-6-abhängigen Proliferation von Prä-B-Zellen
… its specific a-receptor induces dimerization of gp130, activation of th gp130-associated Janus kinases Jak1, Jak2 and Tyk2 and phosphorylation of gp130 at cytoplasmic tyrosine residues. These phosphotyrosines serve as docking sites for SH2-domain containing proteins such as STAT1, STAT3, the …
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Funktion der Protein-Tyrosin-Phosphatase SHP2 bei der Interleukin 6 vermittelten Akutphase - Genregulation und T-Zell-Migration
… containing tyrosine phosphatase) is recruited to gp130, the signaltransducing subunit of the IL-6R-Komplex, und is an adaptor for the Ras/Raf/MAPK-cascade. Here it could be demonstrated, that SHP2 inhibits STAT-dependent gene induction, by dephosphorylating Jaks and gp130. We also tested whether …
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