Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 45 for “"Gout"”.
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GOUT: An aeromedical clinical practice guideline
… project, I am demonstrating the significance of gout in the United States of America, and in particular in the arena of aerospace medicine today. I have created a current clinical practice guideline that allows for the efficient delivery of excellent acute and long term care to flight personnel …
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Improving our Understanding of Patient Adherence in Gout
Medication adherence remains problematic in gout management. Previous work demonstrates that adherence can be classified into intentional and unintentional adherence. Intentional nonadherence is driven by patients’ beliefs and offers the opportunity for early interventions. This thesis aimed to …
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Reengineering a human-like uricase for the treatment of gout
… is an unmet medical need in the treatment of gout. This type of inflammatory arthritis can be efficiently alleviated by the enzyme uricase. This enzyme breaks down uric acid, the causative agent of gout, so it can be flushed from the body. In humans and the other great apes, uricase is a …
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Evaluation of anti-gout potential of selected Malaysian medicinal plants
Gout is a type of arthritis that causes painful inflammation in joints due to the elevation of uric acid in the blood. Allopurinol is a common drug used for treating gout. However, due to unwanted side effects, new alternatives with fewer side effects are desired. The objectives of the study are to …
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PRG4/CD44/PP2A Signaling Axis: A Significant Regulator of Gout Arthritis
<p><strong>Introduction</strong>: Gout is a common chronic arthritis caused by monosodium urate (MSU) crystal deposition in joints leading to activation of synovial resident macrophages and downstream production of interleukin-1b (IL-1b). Xanthine oxidase (XO) catalyzes purines into uric acid (UA) …
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Cluster Determinant 44 (CD44) Receptor and Gout: Mechanistic Role in Pathogenesis and Therapeutic Targets
<p>Gout is considered one of the most common forms of arthritis. It is characterized by sudden, severe attacks of pain, redness, and swelling in the joints. Management of acute gout attacks remains suboptimal, and hospitalizations due to poorly controlled flares have significantly increased over …
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"THE DISTEMPER OF A GENTLEMAN": GROTESQUE VISUAL AND LITERARY DEPICTIONS OF GOUT IN GREAT BRITAIN 1744-1826
… in which visual and literary representations of gout in British literature and popular culture during the period 1744-1826 evince anxieties regarding over-consumption, particularly in relation to imperial expansion. I argue that the prevalence of gout in graphic satire indicates a common cultural …
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Role of Protein Phosphatase-2A in Regulating Monocyte Activation by Soluble and Crystalline Uric Acid in Gout
<p>Gout is a chronic inflammatory disease caused by the phagocytosis of monosodium urate monohydrate (MSU) crystals by monocytes/macrophages resulting in downstream expression and production of interleukin-1 beta (IL-1β) and chemokines. The activation of monocytes by MSU crystals involves the …
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A self-management programme to empower adults suffering from Gout and their caregivers in the Omaheke region, Namibia
The prevalence of gout has increased over the last few decades. Of the 291 conditions studied in the Global Burden of Disease (GBD) (2010), gout ranked 138th for disability and 173rd for the overall burden of disability-adjusted life years. Statistics assume that in a population of 71,233 there are …
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Does Every Picture Tell a Story? The Use of Medical Images for Patient Education
… analysis of images used in existing PEM about gout. The study identified 310 images in 71 publicly available online educational resources about gout. The resources were from medical and health organisations and health education websites from Australia, Canada, Ireland, New Zealand, South …
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Designing Peptide-Based Biosensors for the Diagnosis of Crystal Arthropathies
… accumulate in the joints of patients with acute gout, one of several types of crystal arthropathy. Other arthritides, including pseudo-gout and osteoarthritis, present similar symptoms to gout, but are characterised by accumulation of calcium pyrophosphate and hydroxyapatite crystals …
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Biochemical Studies Of Human Hyperuricaemia
… in two groups of patients: hyperuricaemic and gouty individuals. A group of normal controls has been used for comparison. Human erythrocyte phosphoribosylpyrophosphate synthetase (2.7.6.1.) was found to be much more stable in all samples than has been reported. Kinetic parameters for this …
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Gout Biosensor: Towards the development of a peptide-based diagnostic for crystal arthropathies and Amplifying Graduate Student Perspectives on Supervision and Satisfaction at the University of Calgary
… labelled crystal-targeting peptides to develop a gout biosensor to improve the diagnostics of crystal arthropathies. Additionally, Chapter 7 examines survey responses from a secondary research project exploring graduate student experiences related to supervision and satisfaction within NSERC …
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