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Showing 1 to 6 of 6 for “"Goosecoid"”.
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A role for the Spemann organizer gene, Goosecoid, in tumor metastasis
… gastrulation might be reactivated in tumors. The Goosecoid homeobox transcription factor is a known executer of cell migration from the Spemann organizer. I found that indeed Goosecoid is overexpressed in a majority of human breast tumors. Ectopic expression of Goosecoid in human breast cells …
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Novel Mechanisms of Transcriptional Repression by the Paired-like Homeodomain Transcription Factor Goosecoid
… paired-like homeodomain transcription factors Goosecoid (Gsc) and Mixl1. At the molecular level, Gsc has been described to function as a transcriptional repressor by directly binding to paired homedomain binding sites on target promoters. Here, I describe a novel mechanism of transcriptional …
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The transcription factor grainyhead-like 2 is a novel suppressor of the epithelial to mesenchymal transition
… factors Twist, Snail1/2, ZEB1/2 and goosecoid. Transforming growth factor beta can induce EMT both in the contexts of wound healing and cancer, but some cell types are resistant to this stimulus. Furthermore, knowledge of factors which stabilize the epithelial phenotype is limited but …
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Transcriptional Integration of Wnt and Nodal Signals in the Establishment of the Spemann Organizer
… site within the promoter of the organizer gene Goosecoid (Gsc). Sia/Twn form homodimers and heterodimers through direct homeodomain interaction and both dimer forms are found at the endogenous Gsc promoter. The Gsc promoter also contains a Nodal responsive distal element, suggesting that Sia/Twn …
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Hyperosmotic Stress Enzyme Signaling Modulates Oct4, Nanog, And Rex1 Expression And Induces Prioritized Differentiation Of Murine Embryonic Stem Cells
… and anterior</p> <p>visceral endoderm marker, Goosecoid, expression was suppressed. The timing of</p> <p>stress delivery was very significant in determining its outcome. Hyperosmotic stress</p> <p>delivered at the onset of differentiation induced a prioritized differentiation of mESC,</p> …
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Genetic Analysis of Drosophila Stomatogastric Nervous System
… Myers, which lead to the identification of the goosecoid (Gsc) promoter. The GscG-GAL4 driver is active during SNS development, but switches off at the end of embryogenesis. I then used these lines to demonstrate that the epidermal growth factor receptor (EGFR) plays a role during axon outgrowth …