Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 65 for “"Gonadotropin Releasing Hormone (GnRH)"”.
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Gastrointestinal motility and the role of gonadotropin-releasing hormone (GnRH)
This thesis explores the relation between gonadotropin-releasing hormone (GnRH) and gastrointestinal symptoms and dysmotility. In primary Sjögren’s syndrome (pSS), a patient group with high levels of GnRH antibodies, associations between objective signs and symptoms of autonomic dysfunction (AD), …
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β-arrestin interacting domains on the type II gonadotropin-releasing hormone (GnRH) receptor
… in COS-l cells revealed that the mammalian type GnRH receptor can internalise in a β-arrestin dependent manner whereas the internalisation of the mammalian type I GnRH receptor is β-arrestin independent. investigate which domains on the mammalian type II GnRH receptor are required for β~arrestin …
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The role of Gai in the Gonadotropin-releasing hormone (GnRH) receptor inhibition of cell proliferation
The activation of Gonadotropin-releasing hormone receptor (GnRHR) by the GnRH ligand has been shown to mediate antiproliferative effects in extra-pituitary cells and in reproductive cancer cell lines. The GnRHR couples to Gαq in pituitary gonadotropes. However, the GnRHR expressed in reproductive …
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The role of steroidogenic factor-1 (SF-1) in gonadotropin-releasing hormone (GnRH) receptor gene regulation
Gonadotropin releasing hormone (GnRH) is a key reproductive hormone in vertebrates and exerts its effects via the GnRH receptor (GnRHR) to result in the synthesis and release of the gonadotropin hormones in the pituitary gonadotrope cells. GnRHR expression is likely to be regulated in a tissue- and …
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Σχεδιασμός, σύνθεση και αξιολόγηση πεπτιδικών και μη πεπτιδικών αναλόγων της εκλυτικής ορμόνης των γοναδοτροπινών (Gonadotropin Releasing Hormone, GnRH)
Η εκλυτική ορμόνη των γοναδοτροπινών (GnRH ή LHRH) είναι ένα δεκαπεπτίδιο υπεύθυνο για τον έλεγχο και την απελευθέρωση των γοναδοτροπινών ορμονών LH και FSH και κατ’ επέκταση για τη ρύθμιση της λειτουργίας του αναπαραγωγικού άξονα. Τροποποιημένα πεπτιδικά ανάλογα της GnRH χρησιμοποιούνται για τη …
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The gonadotropin-releasing hormone (GnRH) system: a comparison between breeding and non-breeding naked mole rats (Heterocephalus glaber)
… namely the hypothalamus and the pituitary gland. Gonadotropin-releasing hormone (GnRH) is a neuropeptide typically produced in the hypothalamus. It is the key neuropeptide for initiating this cascade, and without it, reproduction cannot occur. Naked mole rats (Heterocephalus glaber) have a rigid …
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Cloning and characterisation of gonadotropin-releasing hormone (GnRH) receptors in the cichlid (Haplochromis burtoni) and the zebrafish (Danio rerio)
The identification of multiple forms of gonadotropin-releasing hormone (GnRH) in a single species is becoming a common occurrence. The highly conserved chicken GnRH II is present along with one or two other GnRHs, composing a combination unique to particular species. This multifunctional peptide is …
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Physiological Responses of Holstein Cows to Three Superovulatory Methods
… efficacy of continuous follicle stimulating hormone (FSH) administration subcutaneously (SC) via osmotic pumps, (2) assess the benefits of gonadotropin releasing hormone (GnRH) administration on the day of expected estrus and (3) determine the relationship of vaginal electrical resistance …
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The glucocorticoid receptor plays a central role in mammalian reproduction and signal integration in pituitary gonadotropes
… between the glucocorticoid receptor (GR) and gonadotropin-releasing hormone (GnRH) signalling pathways is a potential mechanism for integrating cellular responses to stress with reproductive function. This study investigated if membrane rafts play a role in GR and GnRH receptor (GnRHR) …
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Equine Luteinizing Hormone Profile Characteristics: Effects of Sampling Interval, Method of Analysis, Reproductive State, Gonadotropin-Releasing Hormone and Foal Removal
… several species have indicated that luteinizing hormone (LH) profile characteristics vary with reproductive state. LH profiles may change rapidly, with pulses often occurring on an hourly or even more frequent basis. Only recently have these transitory changes been examined in mares. The results …
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Treatments to Induce and Control Ovulations and Reduce the Incidence of Abnormal Luteal Phases in Postpartum Suckled Beef Cows
… suckled beef cows can be induced to ovulate by gonadotropin releasing hormone (GnRH) but the luteal phase following that ovulation is generally six to twelve days long. It was hypothesized that the presence of a luteolytic compound (prostaglandin F(,2)(alpha)) and the duration of the …
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The role of extracellular loop three of the human gonadotropin releasing hormone receptor in ligand selectivity
The hypothalamic neuropeptide, gonadotropin releasing hormone (GnRH) perferentially inteacts with GnRH type I receptors on the gonadotropes in the anterior pituitary. Activation of the GnRH receptor is required for the biosynthesis and release of luteinizing hormone (LH) and follicle stimulating …
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Ovarian and Pituitary Responses of Seasonally and Postpartum Anestrous Ewes to Gonadotropin Releasing Hormone
… anestrous ewes were treated with saline or gonadotropin releasing hormone (GnRH) either intramuscularly in saline, subcutaneously in carboxymethylcellulose or subcutaneously in a gelatin capsule. Ewes were bled for progesterone determination prior to treatment and up to 13 days after …
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GnRH and neuropeptide regulation of gonadotropin secretion from cultured human pituitary cells
Gonadotropin-releasing hormone (GnRH) and its superactive analogues are currently being used in the treatment of a number of endocrine disorders, such as endometriosis, precocious puberty, infertility and prostatic cancer. Selection of these analogues for clinical use have been previously based on …
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Localization of Luteinizing Hormone-Releasing Hormone (LHRH) in the Hypothalamus of Fetal Bovine
Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH) are mammalian gonadotropins released from the anterior pituitary by Gonadotropin Releasing Hormone (GnRH) in the hypothalamus. Various analogs ofGnRH have been identified. Localization of these hormones is the first step in discovering …
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A mutational analysis of the roles of cytoplasmic domains of the gonadotropin-releasing hormone receptor in coupling and internalization
… importance as the actions of a wide range of hormones and drugs are mediated by these receptors. The gonadotropin-releasing hormone (GnRH) receptor is a member of the GPCR family, and plays a central role in the reproductive system. GnRH analogues are used therapeutically in a number of human …
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A Mathematical Model for the Transition in Firing Patterns Across Puberty of a Gonadotropin-Releasing Hormone Neuron
… activity of a certain network of neurons called Gonadotropin-Releasing Hormone (GnRH) neurons lies at the very heart of this puzzle. For my thesis, I develop and analyze a deterministic mathematical model of a GnRH neuron consisting of a system of differential equations based on experimental …
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Bone morphogenetic proteins (BMPs): new modulators of the follicle stimulating hormone (FSH) synthesis and release
… function requires the secretion of the gonadotropins, luteinizing hormone (LH) and follicle -stimulating hormone (FSH) synthesized by the gonadotrope cells. A tight control of the production of these hormones is crucial, particularly in females, to coordinate the terminal follicular …
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Dysregulation in polycystic ovary syndrome: mechanisms and therapeutic approaches
… It is marked by high levels of androgens (male hormones), irregular ovulation, and metabolic disorders, all of which are linked to disruptions in gonadotropin regulation. The hypothalamic-pituitary-gonadal (HPG) axis plays a key role in reproductive function, controlling the release of …
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The cloning of novel gonadotropin-releasing hormone receptors by polymerase chain reaction
Gonadotropin-releasing hormone (GnRH), a central regulator of reproductive function in all vertebrates, exerts its effects via binding to the GnRH receptor (GnRHR) in the pituitary gonadotrophs. The GnRHR is a member of the G-protein coupled receptor (GPCR) superfarnily. A second form of the GnRHR …
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